Abstract
We have recently shown that in childhood acute lymphoblastic leukemia (ALL) blasts at different stages of immunophenotypic maturation possess stem cell properties. Here, we discuss our results in the context of previous investigations of ALL stem cells and recent studies highlighting specific limitations of the xenotransplantation models for human hematopoietic cells. Leukemia-propagating stem cells in ALL may be more frequent than previously thought!
| Original language | English |
|---|---|
| Pages (from-to) | 996-9 |
| Number of pages | 4 |
| Journal | Cell cycle (Georgetown, Tex.) |
| Volume | 8 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1 Apr 2009 |
| Externally published | Yes |
Keywords
- Animals
- Antigens, CD19/metabolism
- Antigens, CD20/metabolism
- Antigens, CD34/metabolism
- Hematopoietic Stem Cell Transplantation
- Humans
- Mice
- Mice, SCID
- Neoplastic Stem Cells/metabolism
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism
- Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism
- Transplantation, Heterologous/immunology
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