TY - JOUR
T1 - Maintaining physiological testosterone levels by adding dehydroepiandrosterone to combined oral contraceptives
T2 - I. Endocrine effects
AU - Coelingh Bennink, Herjan J T
AU - Zimmerman, Yvette
AU - Laan, Ellen
AU - Termeer, Hanneke M M
AU - Appels, Nicole
AU - Albert, Adelin
AU - Fauser, Bart C J M
AU - Thijssen, Jos H H
AU - van Lunsen, Rik H W
PY - 2017/11
Y1 - 2017/11
N2 - Objective: To determine whether adding dehydroepiandrosterone to combined oral contraceptives (COCs) maintains physiological levels of free testosterone. Study design: A randomized, double-blind, placebo-controlled, two-way crossover study conducted in 81 healthy women (age range: 20-35 years; Body mass index (BMI) range: 18-35 kg/m2) using oral contraceptives. Androgens, sex hormone-binding globulin (SHBG), estradiol (E2) and estrone (E1) were measured, and free testosterone and the free testosterone index were calculated. Subjects discontinued oral contraceptive use for at least one menstrual cycle before being randomized to receive five cycles of ethinyl estradiol (EE) combined with either levonorgestrel (EE/LNG group) or drospirenone (EE/DRSP group) together with either dehydroepiandrosterone (DHEA) (50 mg/day orally) or placebo. Subsequently, all subjects crossed over to the other treatment arm for an additional five cycles. Results: Both COCs decreased the levels of all androgens measured. Significant decreases (p
AB - Objective: To determine whether adding dehydroepiandrosterone to combined oral contraceptives (COCs) maintains physiological levels of free testosterone. Study design: A randomized, double-blind, placebo-controlled, two-way crossover study conducted in 81 healthy women (age range: 20-35 years; Body mass index (BMI) range: 18-35 kg/m2) using oral contraceptives. Androgens, sex hormone-binding globulin (SHBG), estradiol (E2) and estrone (E1) were measured, and free testosterone and the free testosterone index were calculated. Subjects discontinued oral contraceptive use for at least one menstrual cycle before being randomized to receive five cycles of ethinyl estradiol (EE) combined with either levonorgestrel (EE/LNG group) or drospirenone (EE/DRSP group) together with either dehydroepiandrosterone (DHEA) (50 mg/day orally) or placebo. Subsequently, all subjects crossed over to the other treatment arm for an additional five cycles. Results: Both COCs decreased the levels of all androgens measured. Significant decreases (p
KW - Androgens
KW - DHEA
KW - Free testosterone
KW - Oral contraception
KW - SHBG
UR - http://www.scopus.com/inward/record.url?scp=84979255313&partnerID=8YFLogxK
U2 - 10.1016/j.contraception.2016.06.022
DO - 10.1016/j.contraception.2016.06.022
M3 - Article
C2 - 27393080
AN - SCOPUS:84979255313
SN - 0010-7824
VL - 96
SP - 322
EP - 329
JO - Contraception
JF - Contraception
IS - 5
ER -