Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Aurélie Moskal; Heinz Freisling; Graham Byrnes; Nada Assi; Michael T. Fahey; Mazda Jenab; Pietro Ferrari; Anne Tjønneland; Kristina EN Petersen; Christina C. Dahm; Camilla Plambeck Hansen; Aurélie Affret; Marie Christine Boutron-Ruault; Claire Cadeau; Tilman Kühn; Verena Katzke; Khalid Iqbal; Heiner Boeing; Antonia Trichopoulou; Christina Bamia; Androniki Naska; Giovanna Masala; Maria Santucci de Magistris; Sabina Sieri; Rosario Tumino; Carlotta Sacerdote; Petra H. Peeters; Bas H. Bueno-de-Mesquita; Dagrun Engeset; Idlir Licaj; Guri Skeie; Eva Ardanaz; Genevieve Buckland; José M Huerta Castaño; José R. Quirós; Pilar Amiano; Elena Molina-Portillo; Anna Winkvist; Robin Myte; Ulrika Ericson; Emily Sonestedt; Aurora Perez-Cornago; Nick Wareham; Kay Tee Khaw; Inge Huybrechts; Konstantinos K. Tsilidis; Heather Ward; Marc J. Gunter; Nadia Slimani

doi:10.1038/bjc.2016.334

Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Aurélie Moskal^*, Heinz Freisling, Graham Byrnes, Nada Assi, Michael T. Fahey, Mazda Jenab, Pietro Ferrari, Anne Tjønneland, Kristina EN Petersen, Christina C. Dahm, Camilla Plambeck Hansen, Aurélie Affret, Marie Christine Boutron-Ruault, Claire Cadeau, Tilman Kühn, Verena Katzke, Khalid Iqbal, Heiner Boeing, Antonia Trichopoulou, Christina BamiaAndroniki Naska, Giovanna Masala, Maria Santucci de Magistris, Sabina Sieri, Rosario Tumino, Carlotta Sacerdote, Petra H. Peeters, Bas H. Bueno-de-Mesquita, Dagrun Engeset, Idlir Licaj, Guri Skeie, Eva Ardanaz, Genevieve Buckland, José M Huerta Castaño, José R. Quirós, Pilar Amiano, Elena Molina-Portillo, Anna Winkvist, Robin Myte, Ulrika Ericson, Emily Sonestedt, Aurora Perez-Cornago, Nick Wareham, Kay Tee Khaw, Inge Huybrechts, Konstantinos K. Tsilidis, Heather Ward, Marc J. Gunter, Nadia Slimani

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background:Much of the current literature on diet–colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.Results:During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92–0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93–0.99). The remaining two patterns were not significantly associated with CRC risk.Conclusions:Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.

Original language	English
Pages (from-to)	1430-1440
Journal	British Journal of Cancer
Volume	115
Issue number	11
DOIs	https://doi.org/10.1038/bjc.2016.334
Publication status	Published - Nov 2016

Keywords

colon; rectum; nutrients; dietary patterns; EPIC; Europe; PCA

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Moskal, A., Freisling, H., Byrnes, G., Assi, N., Fahey, M. T., Jenab, M., Ferrari, P., Tjønneland, A., Petersen, K. EN., Dahm, C. C., Hansen, C. P., Affret, A., Boutron-Ruault, M. C., Cadeau, C., Kühn, T., Katzke, V., Iqbal, K., Boeing, H., Trichopoulou, A., ... Slimani, N. (2016). Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study. British Journal of Cancer, 115(11), 1430-1440. https://doi.org/10.1038/bjc.2016.334

@article{4a0f73850ce4487086602ed60461caed,

title = "Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study",

abstract = "Background:Much of the current literature on diet–colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.Results:During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92–0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93–0.99). The remaining two patterns were not significantly associated with CRC risk.Conclusions:Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.",

keywords = "colon; rectum; nutrients; dietary patterns; EPIC; Europe; PCA",

author = "Aur{\'e}lie Moskal and Heinz Freisling and Graham Byrnes and Nada Assi and Fahey, {Michael T.} and Mazda Jenab and Pietro Ferrari and Anne Tj{\o}nneland and Petersen, {Kristina EN} and Dahm, {Christina C.} and Hansen, {Camilla Plambeck} and Aur{\'e}lie Affret and Boutron-Ruault, {Marie Christine} and Claire Cadeau and Tilman K{\"u}hn and Verena Katzke and Khalid Iqbal and Heiner Boeing and Antonia Trichopoulou and Christina Bamia and Androniki Naska and Giovanna Masala and {de Magistris}, {Maria Santucci} and Sabina Sieri and Rosario Tumino and Carlotta Sacerdote and Peeters, {Petra H.} and Bueno-de-Mesquita, {Bas H.} and Dagrun Engeset and Idlir Licaj and Guri Skeie and Eva Ardanaz and Genevieve Buckland and Casta{\~n}o, {Jos{\'e} M Huerta} and Quir{\'o}s, {Jos{\'e} R.} and Pilar Amiano and Elena Molina-Portillo and Anna Winkvist and Robin Myte and Ulrika Ericson and Emily Sonestedt and Aurora Perez-Cornago and Nick Wareham and Khaw, {Kay Tee} and Inge Huybrechts and Tsilidis, {Konstantinos K.} and Heather Ward and Gunter, {Marc J.} and Nadia Slimani",

year = "2016",

month = nov,

doi = "10.1038/bjc.2016.334",

language = "English",

volume = "115",

pages = "1430--1440",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "11",

}

Moskal, A, Freisling, H, Byrnes, G, Assi, N, Fahey, MT, Jenab, M, Ferrari, P, Tjønneland, A, Petersen, KEN, Dahm, CC, Hansen, CP, Affret, A, Boutron-Ruault, MC, Cadeau, C, Kühn, T, Katzke, V, Iqbal, K, Boeing, H, Trichopoulou, A, Bamia, C, Naska, A, Masala, G, de Magistris, MS, Sieri, S, Tumino, R, Sacerdote, C, Peeters, PH, Bueno-de-Mesquita, BH, Engeset, D, Licaj, I, Skeie, G, Ardanaz, E, Buckland, G, Castaño, JMH, Quirós, JR, Amiano, P, Molina-Portillo, E, Winkvist, A, Myte, R, Ericson, U, Sonestedt, E, Perez-Cornago, A, Wareham, N, Khaw, KT, Huybrechts, I, Tsilidis, KK, Ward, H, Gunter, MJ & Slimani, N 2016, 'Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study', British Journal of Cancer, vol. 115, no. 11, pp. 1430-1440. https://doi.org/10.1038/bjc.2016.334

TY - JOUR

T1 - Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

AU - Moskal, Aurélie

AU - Freisling, Heinz

AU - Byrnes, Graham

AU - Assi, Nada

AU - Fahey, Michael T.

AU - Jenab, Mazda

AU - Ferrari, Pietro

AU - Tjønneland, Anne

AU - Petersen, Kristina EN

AU - Dahm, Christina C.

AU - Hansen, Camilla Plambeck

AU - Affret, Aurélie

AU - Boutron-Ruault, Marie Christine

AU - Cadeau, Claire

AU - Kühn, Tilman

AU - Katzke, Verena

AU - Iqbal, Khalid

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Bamia, Christina

AU - Naska, Androniki

AU - Masala, Giovanna

AU - de Magistris, Maria Santucci

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Peeters, Petra H.

AU - Bueno-de-Mesquita, Bas H.

AU - Engeset, Dagrun

AU - Licaj, Idlir

AU - Skeie, Guri

AU - Ardanaz, Eva

AU - Buckland, Genevieve

AU - Castaño, José M Huerta

AU - Quirós, José R.

AU - Amiano, Pilar

AU - Molina-Portillo, Elena

AU - Winkvist, Anna

AU - Myte, Robin

AU - Ericson, Ulrika

AU - Sonestedt, Emily

AU - Perez-Cornago, Aurora

AU - Wareham, Nick

AU - Khaw, Kay Tee

AU - Huybrechts, Inge

AU - Tsilidis, Konstantinos K.

AU - Ward, Heather

AU - Gunter, Marc J.

AU - Slimani, Nadia

PY - 2016/11

Y1 - 2016/11

N2 - Background:Much of the current literature on diet–colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.Results:During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92–0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93–0.99). The remaining two patterns were not significantly associated with CRC risk.Conclusions:Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.

AB - Background:Much of the current literature on diet–colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.Results:During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92–0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93–0.99). The remaining two patterns were not significantly associated with CRC risk.Conclusions:Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.

KW - colon; rectum; nutrients; dietary patterns; EPIC; Europe; PCA

UR - http://www.scopus.com/inward/record.url?scp=84992144561&partnerID=8YFLogxK

U2 - 10.1038/bjc.2016.334

DO - 10.1038/bjc.2016.334

M3 - Article

C2 - 27764841

AN - SCOPUS:84992144561

SN - 0007-0920

VL - 115

SP - 1430

EP - 1440

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 11

ER -

Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

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