TY - JOUR
T1 - Magnetic Resonance Imaging-Guided Adaptive Radiation Therapy
T2 - A "Game Changer" for Prostate Treatment?
AU - Pathmanathan, Angela U
AU - van As, Nicholas J
AU - Kerkmeijer, Linda G W
AU - Christodouleas, John
AU - Lawton, Colleen A F
AU - Vesprini, Danny
AU - van der Heide, Uulke A
AU - Frank, Steven J
AU - Nill, Simeon
AU - Oelfke, Uwe
AU - van Herk, Marcel
AU - Li, X Allen
AU - Mittauer, Kathryn
AU - Ritter, Mark
AU - Choudhury, Ananya
AU - Tree, Alison C
N1 - Funding Information:
A.T., A.C., U.O., S.N., and A.P. have received research and educational travel support from Elekta. Elekta financially supports the MR-Linac Consortium and all member institutes, including research funding. Elekta supports travel costs for consortium meetings. A.T., A.P., N.V.A., U.O., and S.N. acknowledge the support of National Health Service funding to the National Institute of Health Research Biomedical Research Centre at The Royal Marsden and The Institute of Cancer Research. The views expressed in this paper are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. Research at the Institute of Cancer Research is also supported by Cancer Research UK (CRUK) (program grant C33589/A19727).
Publisher Copyright:
© 2017 The Authors
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Radiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning. The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation.
AB - Radiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning. The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation.
UR - https://www.scopus.com/pages/publications/85041321822
U2 - 10.1016/j.ijrobp.2017.10.020
DO - 10.1016/j.ijrobp.2017.10.020
M3 - Review article
C2 - 29353654
SN - 0360-3016
VL - 100
SP - 361
EP - 373
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 2
ER -