Macrolides to prevent COPD exacerbations

Sevim Uzun; Remco S. Djamin; Nils E. Van'T Veer; Jan A.J.W. Kluytmans; Anton A.M. Ermens; Henk C. Hoogsteden; Joachim G.J.V. Aerts; Menno M. Van Der Eerden

doi:10.1097/CPM.0000000000000028

Macrolides to prevent COPD exacerbations

Sevim Uzun^*, Remco S. Djamin, Nils E. Van'T Veer, Jan A.J.W. Kluytmans, Anton A.M. Ermens, Henk C. Hoogsteden, Joachim G.J.V. Aerts, Menno M. Van Der Eerden

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) is one of the major health problems in the world. Long-term treatment with macrolide antibiotics is a recent development that has been reported to have beneficial effects on exacerbation frequency. These effects are not only attributed to the antimicrobial effect but also to the immune modulatory effect. Six randomized trials and 1 retrospective study have been performed to investigate the efficacy of macrolides in the prevention of acute exacerbations of COPD. Besides the beneficial effects on the occurrence of exacerbations of COPD, this treatment also seems to improve quality of life and is well tolerated. Antimicrobial resistance is one of the future issues to consider before implementing this therapy.

Original language	English
Pages (from-to)	61-67
Number of pages	7
Journal	Clinical Pulmonary Medicine
Volume	21
Issue number	2
DOIs	https://doi.org/10.1097/CPM.0000000000000028
Publication status	Published - Mar 2014

Keywords

Adverse effects
Antimicrobial resistance
COPD
Immune modulation
Macrolide antibiotics

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title = "Macrolides to prevent COPD exacerbations",

abstract = "Chronic obstructive pulmonary disease (COPD) is one of the major health problems in the world. Long-term treatment with macrolide antibiotics is a recent development that has been reported to have beneficial effects on exacerbation frequency. These effects are not only attributed to the antimicrobial effect but also to the immune modulatory effect. Six randomized trials and 1 retrospective study have been performed to investigate the efficacy of macrolides in the prevention of acute exacerbations of COPD. Besides the beneficial effects on the occurrence of exacerbations of COPD, this treatment also seems to improve quality of life and is well tolerated. Antimicrobial resistance is one of the future issues to consider before implementing this therapy.",

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T1 - Macrolides to prevent COPD exacerbations

AU - Uzun, Sevim

AU - Djamin, Remco S.

AU - Van'T Veer, Nils E.

AU - Kluytmans, Jan A.J.W.

AU - Ermens, Anton A.M.

AU - Hoogsteden, Henk C.

AU - Aerts, Joachim G.J.V.

AU - Van Der Eerden, Menno M.

PY - 2014/3

Y1 - 2014/3

N2 - Chronic obstructive pulmonary disease (COPD) is one of the major health problems in the world. Long-term treatment with macrolide antibiotics is a recent development that has been reported to have beneficial effects on exacerbation frequency. These effects are not only attributed to the antimicrobial effect but also to the immune modulatory effect. Six randomized trials and 1 retrospective study have been performed to investigate the efficacy of macrolides in the prevention of acute exacerbations of COPD. Besides the beneficial effects on the occurrence of exacerbations of COPD, this treatment also seems to improve quality of life and is well tolerated. Antimicrobial resistance is one of the future issues to consider before implementing this therapy.

AB - Chronic obstructive pulmonary disease (COPD) is one of the major health problems in the world. Long-term treatment with macrolide antibiotics is a recent development that has been reported to have beneficial effects on exacerbation frequency. These effects are not only attributed to the antimicrobial effect but also to the immune modulatory effect. Six randomized trials and 1 retrospective study have been performed to investigate the efficacy of macrolides in the prevention of acute exacerbations of COPD. Besides the beneficial effects on the occurrence of exacerbations of COPD, this treatment also seems to improve quality of life and is well tolerated. Antimicrobial resistance is one of the future issues to consider before implementing this therapy.

KW - Adverse effects

KW - Antimicrobial resistance

KW - COPD

KW - Immune modulation

KW - Macrolide antibiotics

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M3 - Article

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VL - 21

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JO - Clinical Pulmonary Medicine

JF - Clinical Pulmonary Medicine

IS - 2

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Macrolides to prevent COPD exacerbations

Abstract

Keywords

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