Lymphocytes at tumor margins in patients with head and neck cancer. Relationship with tumor size, human lymphocyte antigen molecules, and metastasis

P J Slootweg; M de Pagter; R A de Weger; P C de Wilde

doi:10.1016/S0901-5027(05)80110-9

Lymphocytes at tumor margins in patients with head and neck cancer. Relationship with tumor size, human lymphocyte antigen molecules, and metastasis

P J Slootweg, M de Pagter, R A de Weger, P C de Wilde

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A series of 76 patients with head and neck squamous cell carcinoma (HNSCC) was analyzed for the significance of a peritumoral lymphocytic infiltrate (PLI). The composition of PLI was immunohistochemically investigated in frozen material and correlated with other putative prognostically significant variables. PLI was shown to be correlated with the invasion pattern but not with any of the other investigated variables such as tumor size, thickness, and metastasis. However, individual components of PLI were statistically significant: human lymphocyte antigen (HLA)-class II-positive cells correlated with occurrence of metastasis, and CD22-positive cells correlated with tumor size. We conclude that studies on the significance of PLI in HNSCC patients should concentrate on analysis of its individual components.

Original language	English
Pages (from-to)	286-9
Number of pages	4
Journal	International Journal of Oral and Maxillofacial Surgery
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/S0901-5027(05)80110-9
Publication status	Published - 1994

Keywords

Analysis of Variance
Antigens, CD
Antigens, CD4
Antigens, CD8
Antigens, Differentiation, B-Lymphocyte
Carcinoma, Squamous Cell
Cell Adhesion Molecules
HLA Antigens
Head and Neck Neoplasms
Humans
Immunohistochemistry
Lectins
Lymphatic Metastasis
Lymphocyte Count
Lymphocytes, Tumor-Infiltrating
Prognosis
Sialic Acid Binding Ig-like Lectin 2

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10.1016/S0901-5027(05)80110-9

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@article{72f130e35b9743d998c278a605573f56,

title = "Lymphocytes at tumor margins in patients with head and neck cancer. Relationship with tumor size, human lymphocyte antigen molecules, and metastasis",

abstract = "A series of 76 patients with head and neck squamous cell carcinoma (HNSCC) was analyzed for the significance of a peritumoral lymphocytic infiltrate (PLI). The composition of PLI was immunohistochemically investigated in frozen material and correlated with other putative prognostically significant variables. PLI was shown to be correlated with the invasion pattern but not with any of the other investigated variables such as tumor size, thickness, and metastasis. However, individual components of PLI were statistically significant: human lymphocyte antigen (HLA)-class II-positive cells correlated with occurrence of metastasis, and CD22-positive cells correlated with tumor size. We conclude that studies on the significance of PLI in HNSCC patients should concentrate on analysis of its individual components.",

keywords = "Analysis of Variance, Antigens, CD, Antigens, CD4, Antigens, CD8, Antigens, Differentiation, B-Lymphocyte, Carcinoma, Squamous Cell, Cell Adhesion Molecules, HLA Antigens, Head and Neck Neoplasms, Humans, Immunohistochemistry, Lectins, Lymphatic Metastasis, Lymphocyte Count, Lymphocytes, Tumor-Infiltrating, Prognosis, Sialic Acid Binding Ig-like Lectin 2",

author = "Slootweg, {P J} and {de Pagter}, M and {de Weger}, {R A} and {de Wilde}, {P C}",

year = "1994",

doi = "10.1016/S0901-5027(05)80110-9",

language = "English",

volume = "23",

pages = "286--9",

journal = "International Journal of Oral and Maxillofacial Surgery",

issn = "0901-5027",

publisher = "Churchill Livingstone",

number = "5",

}

Lymphocytes at tumor margins in patients with head and neck cancer. Relationship with tumor size, human lymphocyte antigen molecules, and metastasis. / Slootweg, P J; de Pagter, M; de Weger, R A et al.
In: International Journal of Oral and Maxillofacial Surgery, Vol. 23, No. 5, 1994, p. 286-9.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Lymphocytes at tumor margins in patients with head and neck cancer. Relationship with tumor size, human lymphocyte antigen molecules, and metastasis

AU - Slootweg, P J

AU - de Pagter, M

AU - de Weger, R A

AU - de Wilde, P C

PY - 1994

Y1 - 1994

N2 - A series of 76 patients with head and neck squamous cell carcinoma (HNSCC) was analyzed for the significance of a peritumoral lymphocytic infiltrate (PLI). The composition of PLI was immunohistochemically investigated in frozen material and correlated with other putative prognostically significant variables. PLI was shown to be correlated with the invasion pattern but not with any of the other investigated variables such as tumor size, thickness, and metastasis. However, individual components of PLI were statistically significant: human lymphocyte antigen (HLA)-class II-positive cells correlated with occurrence of metastasis, and CD22-positive cells correlated with tumor size. We conclude that studies on the significance of PLI in HNSCC patients should concentrate on analysis of its individual components.

AB - A series of 76 patients with head and neck squamous cell carcinoma (HNSCC) was analyzed for the significance of a peritumoral lymphocytic infiltrate (PLI). The composition of PLI was immunohistochemically investigated in frozen material and correlated with other putative prognostically significant variables. PLI was shown to be correlated with the invasion pattern but not with any of the other investigated variables such as tumor size, thickness, and metastasis. However, individual components of PLI were statistically significant: human lymphocyte antigen (HLA)-class II-positive cells correlated with occurrence of metastasis, and CD22-positive cells correlated with tumor size. We conclude that studies on the significance of PLI in HNSCC patients should concentrate on analysis of its individual components.

KW - Analysis of Variance

KW - Antigens, CD

KW - Antigens, CD4

KW - Antigens, CD8

KW - Antigens, Differentiation, B-Lymphocyte

KW - Carcinoma, Squamous Cell

KW - Cell Adhesion Molecules

KW - HLA Antigens

KW - Head and Neck Neoplasms

KW - Humans

KW - Immunohistochemistry

KW - Lectins

KW - Lymphatic Metastasis

KW - Lymphocyte Count

KW - Lymphocytes, Tumor-Infiltrating

KW - Prognosis

KW - Sialic Acid Binding Ig-like Lectin 2

U2 - 10.1016/S0901-5027(05)80110-9

DO - 10.1016/S0901-5027(05)80110-9

M3 - Article

C2 - 7890970

SN - 0901-5027

VL - 23

SP - 286

EP - 289

JO - International Journal of Oral and Maxillofacial Surgery

JF - International Journal of Oral and Maxillofacial Surgery

IS - 5

ER -

Lymphocytes at tumor margins in patients with head and neck cancer. Relationship with tumor size, human lymphocyte antigen molecules, and metastasis

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Keywords

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