TY - JOUR
T1 - Lymphoblastic lymphoma with a triple-hit profile
T2 - a rare but distinct and relevant entity
AU - Hiemcke-Jiwa, Laura S.
AU - Leguit, RJ
AU - van der Veken, Lars T.
AU - Buijs, A
AU - Leeuwis, JW
AU - de Boer, Mirthe
AU - Jiwa, Mehdi
AU - Bloem, AC
AU - Clevers-Petersen, E.J.
AU - de Weger, Roel A.
AU - Huibers, Manon M.H.
PY - 2017/5
Y1 - 2017/5
N2 - Follicular lymphoma with progression to a high-grade lymphoma bears a poor prognosis. We describe a case of a 60-year-old man who presented in 2012 with an epidural mass, diagnosed as a diffuse large B-cell lymphoma (DLBCL) with concurrent low-grade follicular lymphoma. Three years later, the patient presented with a cervical mass, diagnosed as a lymphoblastic lymphoma (LBL). Both the DLBCL and LBL contained a “triple hit” with BCL2, BCL6, and cMYC translocations demonstrated by fluorescence in situ hybridization analysis and a complex karyotype by single-nucleotide polymorphism array analysis. Furthermore, the 2 lymphomas were shown to be clonally related by clonality analysis and single-nucleotide polymorphism array analysis. This case report presents a highly unusual case of an LBL with a triple hit, originating from a DLBCL, which has rarely been described in the literature and deserves further exploration.
AB - Follicular lymphoma with progression to a high-grade lymphoma bears a poor prognosis. We describe a case of a 60-year-old man who presented in 2012 with an epidural mass, diagnosed as a diffuse large B-cell lymphoma (DLBCL) with concurrent low-grade follicular lymphoma. Three years later, the patient presented with a cervical mass, diagnosed as a lymphoblastic lymphoma (LBL). Both the DLBCL and LBL contained a “triple hit” with BCL2, BCL6, and cMYC translocations demonstrated by fluorescence in situ hybridization analysis and a complex karyotype by single-nucleotide polymorphism array analysis. Furthermore, the 2 lymphomas were shown to be clonally related by clonality analysis and single-nucleotide polymorphism array analysis. This case report presents a highly unusual case of an LBL with a triple hit, originating from a DLBCL, which has rarely been described in the literature and deserves further exploration.
KW - Complex karyotype
KW - Lymphoblastic lymphoma
KW - SNP array
KW - Transformation
KW - Triple hit
UR - http://www.scopus.com/inward/record.url?scp=85017970000&partnerID=8YFLogxK
U2 - 10.1016/j.humpath.2016.11.002
DO - 10.1016/j.humpath.2016.11.002
M3 - Article
C2 - 27867103
AN - SCOPUS:85017970000
SN - 0046-8177
VL - 63
SP - 171
EP - 176
JO - Human Pathology
JF - Human Pathology
ER -