Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir

radboud van Luin; Marchina E Van der Ende; rijnstate Richter; Mirjam Visser; Diari Faraj; radboud Van der Ven; Luc Gelinck; Frank Kroon; Ferdinand W Wit; erasmus Van Schaik; rijnstate Kuks; radboud Burger

doi:10.1097/QAD.0b013e3283389129

Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir

radboud van Luin
, Marchina E Van der Ende
, rijnstate Richter
, Mirjam Visser
, Diari Faraj
, radboud Van der Ven
, Luc Gelinck
, Frank Kroon
, Ferdinand W Wit
, erasmus Van Schaik
, rijnstate Kuks
, radboud Burger

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

HIV-infected travellers frequently use atovaquone/proguanil as malaria prophylaxis. We compared atovaquone/proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir. The geometric mean ratio (95% confidence interval) area under the curve (AUC)0-->t for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.35-0.83) for patients on efavirenz, lopinavir/ritonavir and atazanavir/ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.

Original language	English
Pages (from-to)	1223-6
Number of pages	4
Journal	AIDS (London, England)
Volume	24
Issue number	8
DOIs	https://doi.org/10.1097/QAD.0b013e3283389129
Publication status	Published - 15 May 2010
Externally published	Yes

Keywords

Adolescent
Adult
Aged
Alkynes
Atazanavir Sulfate
Atovaquone/blood
Benzoxazines/administration & dosage
Cyclopropanes
Drug Administration Schedule
Female
HIV Infections/drug therapy
HIV Protease Inhibitors
HIV-1
Humans
Lopinavir
Male
Middle Aged
Oligopeptides/administration & dosage
Proguanil/blood
Pyridines/administration & dosage
Pyrimidinones/administration & dosage
Ritonavir/administration & dosage
Young Adult

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10.1097/QAD.0b013e3283389129

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van Luin, R., Van der Ende, M. E., Richter, R., Visser, M., Faraj, D., Van der Ven, R., Gelinck, L., Kroon, F., Wit, F. W., Van Schaik, E., Kuks, R., & Burger, R. (2010). Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir. AIDS (London, England), 24(8), 1223-6. https://doi.org/10.1097/QAD.0b013e3283389129

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title = "Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir",

abstract = "HIV-infected travellers frequently use atovaquone/proguanil as malaria prophylaxis. We compared atovaquone/proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir. The geometric mean ratio (95\% confidence interval) area under the curve (AUC)0-->t for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.35-0.83) for patients on efavirenz, lopinavir/ritonavir and atazanavir/ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43\%). Physicians should be alert for atovaquone/proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.",

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day = "15",

doi = "10.1097/QAD.0b013e3283389129",

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T1 - Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir

AU - van Luin, radboud

AU - Van der Ende, Marchina E

AU - Richter, rijnstate

AU - Visser, Mirjam

AU - Faraj, Diari

AU - Van der Ven, radboud

AU - Gelinck, Luc

AU - Kroon, Frank

AU - Wit, Ferdinand W

AU - Van Schaik, erasmus

AU - Kuks, rijnstate

AU - Burger, radboud

PY - 2010/5/15

Y1 - 2010/5/15

N2 - HIV-infected travellers frequently use atovaquone/proguanil as malaria prophylaxis. We compared atovaquone/proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir. The geometric mean ratio (95% confidence interval) area under the curve (AUC)0-->t for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.35-0.83) for patients on efavirenz, lopinavir/ritonavir and atazanavir/ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.

AB - HIV-infected travellers frequently use atovaquone/proguanil as malaria prophylaxis. We compared atovaquone/proguanil pharmacokinetics between healthy volunteers and HIV-infected patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir. The geometric mean ratio (95% confidence interval) area under the curve (AUC)0-->t for atovaquone relative to the healthy volunteers was 0.25 (0.16-0.38), 0.26 (0.17-0.41) and 0.54 (0.35-0.83) for patients on efavirenz, lopinavir/ritonavir and atazanavir/ritonavir, respectively. Proguanil plasma concentrations were also significantly lower (38-43%). Physicians should be alert for atovaquone/proguanil prophylaxis failures in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.

KW - Adolescent

KW - Adult

KW - Aged

KW - Alkynes

KW - Atazanavir Sulfate

KW - Atovaquone/blood

KW - Benzoxazines/administration & dosage

KW - Cyclopropanes

KW - Drug Administration Schedule

KW - Female

KW - HIV Infections/drug therapy

KW - HIV Protease Inhibitors

KW - HIV-1

KW - Humans

KW - Lopinavir

KW - Male

KW - Middle Aged

KW - Oligopeptides/administration & dosage

KW - Proguanil/blood

KW - Pyridines/administration & dosage

KW - Pyrimidinones/administration & dosage

KW - Ritonavir/administration & dosage

KW - Young Adult

U2 - 10.1097/QAD.0b013e3283389129

DO - 10.1097/QAD.0b013e3283389129

M3 - Article

C2 - 20299957

SN - 0269-9370

VL - 24

SP - 1223

EP - 1226

JO - AIDS (London, England)

JF - AIDS (London, England)

IS - 8

ER -

Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir

Abstract

Keywords

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