Low Skeletal Muscle Mass: A Strong Predictive Factor for Surgical Complications After Free Forearm Flap Reconstruction in Oral Cancer Patients

E. Ansari; N. Carrillo Minulina; M. A. van Beers; R. J.J. van Es; F. J. Dieleman; A. J.W.P. Rosenberg; L. M. Janssen; W. W. Braunius; E. M. Van Cann; R. de Bree

doi:10.1002/hed.28014

Low Skeletal Muscle Mass: A Strong Predictive Factor for Surgical Complications After Free Forearm Flap Reconstruction in Oral Cancer Patients

E. Ansari
, N. Carrillo Minulina
, M. A. van Beers
, R. J.J. van Es
, F. J. Dieleman
, A. J.W.P. Rosenberg
, L. M. Janssen
, W. W. Braunius
, E. M. Van Cann
, R. de Bree^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Low skeletal muscle mass (SMM) is a predictive factor for complications in patients undergoing major head and neck cancer surgery. This study aims to identify the predictive value of low SMM for postoperative complications in patients who underwent free forearm flap (FAFF) reconstructions after oral cancer resections. Methods: A retrospective study was performed with all patients who underwent FFAF between 2003 and 2020 for an oral cavity reconstruction after cancer ablation. Free flap related, any postoperative complications and hospital stay were investigated. Results: Low SMM was associated with an increased risk of free flap associated complications (OR 2.14; 95% CI 1.02–4.39, p = 0.029). Low SMM was associated with severe complications (Clavien–Dindo ≥ III) (OR 1.46; 95% CI 1.20–2.09, p = 0.02). Conclusions: Low SMM is a strong predictive factor for free flap related surgical complications in patients undergoing FAFF reconstruction after resection of oral cancer.

Original language	English
Pages (from-to)	1135-1141
Number of pages	7
Journal	Head and Neck
Volume	47
Issue number	4
Early online date	27 Nov 2024
DOIs	https://doi.org/10.1002/hed.28014
Publication status	Published - Apr 2025

Keywords

body composition
free ulnar forearm flap
oral cancer
oral reconstruction
radial forearm free flap
sarcopenia
skeletal muscle mass

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Head Neck - 2024 - Ansari - Low Skeletal Muscle Mass A Strong Predictive Factor for Surgical Complications After FreeFinal published version, 263 KBLicence: CC BY

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Ansari, E., Minulina, N. C., van Beers, M. A., van Es, R. J. J., Dieleman, F. J., Rosenberg, A. J. W. P., Janssen, L. M., Braunius, W. W., Van Cann, E. M., & de Bree, R. (2025). Low Skeletal Muscle Mass: A Strong Predictive Factor for Surgical Complications After Free Forearm Flap Reconstruction in Oral Cancer Patients. Head and Neck, 47(4), 1135-1141. https://doi.org/10.1002/hed.28014

@article{087660f8947542be9e5e689580c1037a,

title = "Low Skeletal Muscle Mass: A Strong Predictive Factor for Surgical Complications After Free Forearm Flap Reconstruction in Oral Cancer Patients",

abstract = "Background: Low skeletal muscle mass (SMM) is a predictive factor for complications in patients undergoing major head and neck cancer surgery. This study aims to identify the predictive value of low SMM for postoperative complications in patients who underwent free forearm flap (FAFF) reconstructions after oral cancer resections. Methods: A retrospective study was performed with all patients who underwent FFAF between 2003 and 2020 for an oral cavity reconstruction after cancer ablation. Free flap related, any postoperative complications and hospital stay were investigated. Results: Low SMM was associated with an increased risk of free flap associated complications (OR 2.14; 95\% CI 1.02–4.39, p = 0.029). Low SMM was associated with severe complications (Clavien–Dindo ≥ III) (OR 1.46; 95\% CI 1.20–2.09, p = 0.02). Conclusions: Low SMM is a strong predictive factor for free flap related surgical complications in patients undergoing FAFF reconstruction after resection of oral cancer.",

keywords = "body composition, free ulnar forearm flap, oral cancer, oral reconstruction, radial forearm free flap, sarcopenia, skeletal muscle mass",

author = "E. Ansari and Minulina, \{N. Carrillo\} and \{van Beers\}, \{M. A.\} and \{van Es\}, \{R. J.J.\} and Dieleman, \{F. J.\} and Rosenberg, \{A. J.W.P.\} and Janssen, \{L. M.\} and Braunius, \{W. W.\} and \{Van Cann\}, \{E. M.\} and \{de Bree\}, R.",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Head \& Neck published by Wiley Periodicals LLC.",

year = "2025",

month = apr,

doi = "10.1002/hed.28014",

language = "English",

volume = "47",

pages = "1135--1141",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley \& Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Low Skeletal Muscle Mass

T2 - A Strong Predictive Factor for Surgical Complications After Free Forearm Flap Reconstruction in Oral Cancer Patients

AU - Ansari, E.

AU - Minulina, N. Carrillo

AU - van Beers, M. A.

AU - van Es, R. J.J.

AU - Dieleman, F. J.

AU - Rosenberg, A. J.W.P.

AU - Janssen, L. M.

AU - Braunius, W. W.

AU - Van Cann, E. M.

AU - de Bree, R.

PY - 2025/4

Y1 - 2025/4

N2 - Background: Low skeletal muscle mass (SMM) is a predictive factor for complications in patients undergoing major head and neck cancer surgery. This study aims to identify the predictive value of low SMM for postoperative complications in patients who underwent free forearm flap (FAFF) reconstructions after oral cancer resections. Methods: A retrospective study was performed with all patients who underwent FFAF between 2003 and 2020 for an oral cavity reconstruction after cancer ablation. Free flap related, any postoperative complications and hospital stay were investigated. Results: Low SMM was associated with an increased risk of free flap associated complications (OR 2.14; 95% CI 1.02–4.39, p = 0.029). Low SMM was associated with severe complications (Clavien–Dindo ≥ III) (OR 1.46; 95% CI 1.20–2.09, p = 0.02). Conclusions: Low SMM is a strong predictive factor for free flap related surgical complications in patients undergoing FAFF reconstruction after resection of oral cancer.

AB - Background: Low skeletal muscle mass (SMM) is a predictive factor for complications in patients undergoing major head and neck cancer surgery. This study aims to identify the predictive value of low SMM for postoperative complications in patients who underwent free forearm flap (FAFF) reconstructions after oral cancer resections. Methods: A retrospective study was performed with all patients who underwent FFAF between 2003 and 2020 for an oral cavity reconstruction after cancer ablation. Free flap related, any postoperative complications and hospital stay were investigated. Results: Low SMM was associated with an increased risk of free flap associated complications (OR 2.14; 95% CI 1.02–4.39, p = 0.029). Low SMM was associated with severe complications (Clavien–Dindo ≥ III) (OR 1.46; 95% CI 1.20–2.09, p = 0.02). Conclusions: Low SMM is a strong predictive factor for free flap related surgical complications in patients undergoing FAFF reconstruction after resection of oral cancer.

KW - body composition

KW - free ulnar forearm flap

KW - oral cancer

KW - oral reconstruction

KW - radial forearm free flap

KW - sarcopenia

KW - skeletal muscle mass

UR - https://www.scopus.com/pages/publications/85210377030

U2 - 10.1002/hed.28014

DO - 10.1002/hed.28014

M3 - Article

C2 - 39601205

AN - SCOPUS:85210377030

SN - 1043-3074

VL - 47

SP - 1135

EP - 1141

JO - Head and Neck

JF - Head and Neck

IS - 4

ER -

Low Skeletal Muscle Mass: A Strong Predictive Factor for Surgical Complications After Free Forearm Flap Reconstruction in Oral Cancer Patients

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