Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study

Carolien N H Abheiden; Birgit S. Blomjous; Sylvia J. Kroese; Irene E M Bultink; Ruth D E Fritsch-Stork; A. Titia Lely; Marjon A. de Boer; Johanna I P de Vries

doi:10.1080/10641955.2016.1217337

Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study

Carolien N H Abheiden^*
, Birgit S. Blomjous
, Sylvia J. Kroese
, Irene E M Bultink
, Ruth D E Fritsch-Stork
, A. Titia Lely
, Marjon A. de Boer
, Johanna I P de Vries

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p <0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.

Original language	English
Pages (from-to)	8-15
Number of pages	8
Journal	Hypertension and Pregnancy
Volume	36
Issue number	1
DOIs	https://doi.org/10.1080/10641955.2016.1217337
Publication status	Published - Feb 2017

Keywords

Antiphospholipid syndrome
aspirin
hypertensive disorders of pregnancy
low-molecular-weight heparin
systemic lupus erythematosus

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10.1080/10641955.2016.1217337Licence: CC BY-NC-ND

Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndromeFinal published version, 1.06 MBLicence: CC BY-NC-ND

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Abheiden, C. N. H., Blomjous, B. S., Kroese, S. J., Bultink, I. E. M., Fritsch-Stork, R. D. E., Lely, A. T., de Boer, M. A., & de Vries, J. I. P. (2017). Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study. Hypertension and Pregnancy, 36(1), 8-15. https://doi.org/10.1080/10641955.2016.1217337

@article{7370a193b5ec4968a023dbdb470acde8,

title = "Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study",

abstract = "Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4\%, 23.3\%, 50\%, 18.4\%, respectively, p = 0.12) and preterm birth (16.7\%, 34.3\%, 75\%, 36.8\%, respectively, p <0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.",

keywords = "Antiphospholipid syndrome, aspirin, hypertensive disorders of pregnancy, low-molecular-weight heparin, systemic lupus erythematosus",

author = "Abheiden, \{Carolien N H\} and Blomjous, \{Birgit S.\} and Kroese, \{Sylvia J.\} and Bultink, \{Irene E M\} and Fritsch-Stork, \{Ruth D E\} and Lely, \{A. Titia\} and \{de Boer\}, \{Marjon A.\} and \{de Vries\}, \{Johanna I P\}",

note = "Publisher Copyright: {\textcopyright}, Published with license by Taylor \& Francis Group, LLC {\textcopyright} Carolien N. H. Abheiden, Birgit S. Blomjous, Sylvia J. Kroese, Irene E. M. Bultnik, Ruth D. E. Fritsch-Stork, A. Titia Lely, Marjon A. de Boer, and Johanna I. P. de Vries.",

year = "2017",

month = feb,

doi = "10.1080/10641955.2016.1217337",

language = "English",

volume = "36",

pages = "8--15",

journal = "Hypertension and Pregnancy",

issn = "1064-1955",

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Abheiden, CNH, Blomjous, BS, Kroese, SJ, Bultink, IEM, Fritsch-Stork, RDE, Lely, AT, de Boer, MA & de Vries, JIP 2017, 'Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study', Hypertension and Pregnancy, vol. 36, no. 1, pp. 8-15. https://doi.org/10.1080/10641955.2016.1217337

Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study. / Abheiden, Carolien N H; Blomjous, Birgit S.; Kroese, Sylvia J. et al.
In: Hypertension and Pregnancy, Vol. 36, No. 1, 02.2017, p. 8-15.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome

T2 - A cohort study

AU - Abheiden, Carolien N H

AU - Blomjous, Birgit S.

AU - Kroese, Sylvia J.

AU - Bultink, Irene E M

AU - Fritsch-Stork, Ruth D E

AU - Lely, A. Titia

AU - de Boer, Marjon A.

AU - de Vries, Johanna I P

N1 - Publisher Copyright: ©, Published with license by Taylor & Francis Group, LLC © Carolien N. H. Abheiden, Birgit S. Blomjous, Sylvia J. Kroese, Irene E. M. Bultnik, Ruth D. E. Fritsch-Stork, A. Titia Lely, Marjon A. de Boer, and Johanna I. P. de Vries.

PY - 2017/2

Y1 - 2017/2

N2 - Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p <0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.

AB - Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p <0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.

KW - Antiphospholipid syndrome

KW - aspirin

KW - hypertensive disorders of pregnancy

KW - low-molecular-weight heparin

KW - systemic lupus erythematosus

UR - https://www.scopus.com/pages/publications/84986199921

U2 - 10.1080/10641955.2016.1217337

DO - 10.1080/10641955.2016.1217337

M3 - Article

C2 - 27599157

AN - SCOPUS:84986199921

SN - 1064-1955

VL - 36

SP - 8

EP - 15

JO - Hypertension and Pregnancy

JF - Hypertension and Pregnancy

IS - 1

ER -

Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome: A cohort study

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