TY - JOUR
T1 - Low-molecular-weight heparin and aspirin use in relation to pregnancy outcome in women with systemic lupus erythematosus and antiphospholipid syndrome
T2 - A cohort study
AU - Abheiden, Carolien N H
AU - Blomjous, Birgit S.
AU - Kroese, Sylvia J.
AU - Bultink, Irene E M
AU - Fritsch-Stork, Ruth D E
AU - Lely, A. Titia
AU - de Boer, Marjon A.
AU - de Vries, Johanna I P
N1 - Publisher Copyright:
©, Published with license by Taylor & Francis Group, LLC © Carolien N. H. Abheiden, Birgit S. Blomjous, Sylvia J. Kroese, Irene E. M. Bultnik, Ruth D. E. Fritsch-Stork, A. Titia Lely, Marjon A. de Boer, and Johanna I. P. de Vries.
PY - 2017/2
Y1 - 2017/2
N2 - Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p <0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.
AB - Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p <0.001). Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.
KW - Antiphospholipid syndrome
KW - aspirin
KW - hypertensive disorders of pregnancy
KW - low-molecular-weight heparin
KW - systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=84986199921&partnerID=8YFLogxK
U2 - 10.1080/10641955.2016.1217337
DO - 10.1080/10641955.2016.1217337
M3 - Article
C2 - 27599157
AN - SCOPUS:84986199921
SN - 1064-1955
VL - 36
SP - 8
EP - 15
JO - Hypertension and Pregnancy
JF - Hypertension and Pregnancy
IS - 1
ER -