Long-term survival after multimodal treatment of sinonasal NUT carcinoma: a case report

J A Rijken; M de Ridder; L A Devriese; G E Breimer

doi:10.1016/j.oraloncology.2025.107392

Long-term survival after multimodal treatment of sinonasal NUT carcinoma: a case report

J A Rijken, M de Ridder, L A Devriese, G E Breimer

Research output: Contribution to journal › Letter › Academic › peer-review

Abstract

Sinonasal NUT carcinoma is a highly aggressive malignancy with poor prognosis. This case demonstrates that combined surgical resection, high-dose radiotherapy, and chemotherapy can lead to long-term remission, with the patient remaining disease-free after five years. Early diagnosis and a multidisciplinary approach are crucial. Continued research into targeted therapies like BET inhibitors holds promise for improving outcomes in this rare, challenging tumor.

Original language	English
Article number	107392
Journal	Oral Oncology
Volume	166
Early online date	28 May 2025
DOIs	https://doi.org/10.1016/j.oraloncology.2025.107392
Publication status	Published - Jul 2025

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title = "Long-term survival after multimodal treatment of sinonasal NUT carcinoma: a case report",

abstract = "Sinonasal NUT carcinoma is a highly aggressive malignancy with poor prognosis. This case demonstrates that combined surgical resection, high-dose radiotherapy, and chemotherapy can lead to long-term remission, with the patient remaining disease-free after five years. Early diagnosis and a multidisciplinary approach are crucial. Continued research into targeted therapies like BET inhibitors holds promise for improving outcomes in this rare, challenging tumor.",

author = "Rijken, {J A} and {de Ridder}, M and Devriese, {L A} and Breimer, {G E}",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd",

year = "2025",

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doi = "10.1016/j.oraloncology.2025.107392",

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T2 - a case report

AU - Rijken, J A

AU - de Ridder, M

AU - Devriese, L A

AU - Breimer, G E

PY - 2025/7

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N2 - Sinonasal NUT carcinoma is a highly aggressive malignancy with poor prognosis. This case demonstrates that combined surgical resection, high-dose radiotherapy, and chemotherapy can lead to long-term remission, with the patient remaining disease-free after five years. Early diagnosis and a multidisciplinary approach are crucial. Continued research into targeted therapies like BET inhibitors holds promise for improving outcomes in this rare, challenging tumor.

AB - Sinonasal NUT carcinoma is a highly aggressive malignancy with poor prognosis. This case demonstrates that combined surgical resection, high-dose radiotherapy, and chemotherapy can lead to long-term remission, with the patient remaining disease-free after five years. Early diagnosis and a multidisciplinary approach are crucial. Continued research into targeted therapies like BET inhibitors holds promise for improving outcomes in this rare, challenging tumor.

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U2 - 10.1016/j.oraloncology.2025.107392

DO - 10.1016/j.oraloncology.2025.107392

M3 - Letter

C2 - 40440826

SN - 1368-8375

VL - 166

JO - Oral Oncology

JF - Oral Oncology

M1 - 107392

ER -

Long-term survival after multimodal treatment of sinonasal NUT carcinoma: a case report

Abstract

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