Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever

Sheila B Buijs; Sanne K Stuart; Jan Jelrik Oosterheert; Steffi Karhof; Andy I M Hoepelman; Nicole H M Renders; André S van Petersen; Chantal P Bleeker-Rovers; Peter C Wever; Olivier H J Koning

doi:10.1007/s10096-021-04179-5

Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever

Sheila B Buijs, Sanne K Stuart, Jan Jelrik Oosterheert, Steffi Karhof, Andy I M Hoepelman, Nicole H M Renders, André S van Petersen, Chantal P Bleeker-Rovers, Peter C Wever, Olivier H J Koning

Research output: Contribution to journal › Article › Academic › peer-review

8 Downloads (Pure)

Abstract

We evaluated the long-term serological follow-up of patients with vascular risk factors for chronic Q fever that were previously Coxiella burnetii seropositive. C. burnetii phase I IgG titers were reevaluated in patients that gave informed consent or retrospectively collected in patients already deceased or lost to follow-up. Of 107 patients, 25 (23.4%) became seronegative, 77 (72.0%) retained a profile of past resolved Q fever infection, and five (4.7%) developed chronic Q fever. We urge clinicians to stay vigilant for chronic Q fever beyond two years after primary infection and perform serological testing based on clinical presentation.

Original language	English
Pages (from-to)	1569-1572
Number of pages	4
Journal	European Journal of Clinical Microbiology & Infectious Diseases
Volume	40
Issue number	7
Early online date	10 Feb 2021
DOIs	https://doi.org/10.1007/s10096-021-04179-5
Publication status	Published - Jul 2021

Keywords

Aneurysm
Blood vessel prosthesis
Coxiella burnetii
Q fever
Serology

Access to Document

10.1007/s10096-021-04179-5Licence: CC BY

Buijs2021_Article_Long-termSerologicalFollow-upAFinal published version, 202 KBLicence: CC BY

Cite this

Buijs, S. B., Stuart, S. K., Oosterheert, J. J., Karhof, S., Hoepelman, A. I. M., Renders, N. H. M., van Petersen, A. S., Bleeker-Rovers, C. P., Wever, P. C., & Koning, O. H. J. (2021). Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever. European Journal of Clinical Microbiology & Infectious Diseases, 40(7), 1569-1572. https://doi.org/10.1007/s10096-021-04179-5

@article{6d394289774944bf9c0af6b1ca15df16,

title = "Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever",

abstract = "We evaluated the long-term serological follow-up of patients with vascular risk factors for chronic Q fever that were previously Coxiella burnetii seropositive. C. burnetii phase I IgG titers were reevaluated in patients that gave informed consent or retrospectively collected in patients already deceased or lost to follow-up. Of 107 patients, 25 (23.4%) became seronegative, 77 (72.0%) retained a profile of past resolved Q fever infection, and five (4.7%) developed chronic Q fever. We urge clinicians to stay vigilant for chronic Q fever beyond two years after primary infection and perform serological testing based on clinical presentation.",

keywords = "Aneurysm, Blood vessel prosthesis, Coxiella burnetii, Q fever, Serology",

author = "Buijs, {Sheila B} and Stuart, {Sanne K} and Oosterheert, {Jan Jelrik} and Steffi Karhof and Hoepelman, {Andy I M} and Renders, {Nicole H M} and {van Petersen}, {Andr{\'e} S} and Bleeker-Rovers, {Chantal P} and Wever, {Peter C} and Koning, {Olivier H J}",

year = "2021",

month = jul,

doi = "10.1007/s10096-021-04179-5",

language = "English",

volume = "40",

pages = "1569--1572",

journal = "European Journal of Clinical Microbiology & Infectious Diseases",

issn = "0934-9723",

publisher = "Springer-Verlag",

number = "7",

}

Buijs, SB, Stuart, SK, Oosterheert, JJ, Karhof, S, Hoepelman, AIM, Renders, NHM, van Petersen, AS, Bleeker-Rovers, CP, Wever, PC & Koning, OHJ 2021, 'Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever', European Journal of Clinical Microbiology & Infectious Diseases, vol. 40, no. 7, pp. 1569-1572. https://doi.org/10.1007/s10096-021-04179-5

Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever. / Buijs, Sheila B; Stuart, Sanne K; Oosterheert, Jan Jelrik et al.
In: European Journal of Clinical Microbiology & Infectious Diseases, Vol. 40, No. 7, 07.2021, p. 1569-1572.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever

AU - Buijs, Sheila B

AU - Stuart, Sanne K

AU - Oosterheert, Jan Jelrik

AU - Karhof, Steffi

AU - Hoepelman, Andy I M

AU - Renders, Nicole H M

AU - van Petersen, André S

AU - Bleeker-Rovers, Chantal P

AU - Wever, Peter C

AU - Koning, Olivier H J

PY - 2021/7

Y1 - 2021/7

N2 - We evaluated the long-term serological follow-up of patients with vascular risk factors for chronic Q fever that were previously Coxiella burnetii seropositive. C. burnetii phase I IgG titers were reevaluated in patients that gave informed consent or retrospectively collected in patients already deceased or lost to follow-up. Of 107 patients, 25 (23.4%) became seronegative, 77 (72.0%) retained a profile of past resolved Q fever infection, and five (4.7%) developed chronic Q fever. We urge clinicians to stay vigilant for chronic Q fever beyond two years after primary infection and perform serological testing based on clinical presentation.

AB - We evaluated the long-term serological follow-up of patients with vascular risk factors for chronic Q fever that were previously Coxiella burnetii seropositive. C. burnetii phase I IgG titers were reevaluated in patients that gave informed consent or retrospectively collected in patients already deceased or lost to follow-up. Of 107 patients, 25 (23.4%) became seronegative, 77 (72.0%) retained a profile of past resolved Q fever infection, and five (4.7%) developed chronic Q fever. We urge clinicians to stay vigilant for chronic Q fever beyond two years after primary infection and perform serological testing based on clinical presentation.

KW - Aneurysm

KW - Blood vessel prosthesis

KW - Coxiella burnetii

KW - Q fever

KW - Serology

UR - http://www.scopus.com/inward/record.url?scp=85100835094&partnerID=8YFLogxK

U2 - 10.1007/s10096-021-04179-5

DO - 10.1007/s10096-021-04179-5

M3 - Article

C2 - 33566203

SN - 0934-9723

VL - 40

SP - 1569

EP - 1572

JO - European Journal of Clinical Microbiology & Infectious Diseases

JF - European Journal of Clinical Microbiology & Infectious Diseases

IS - 7

ER -

Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this