TY - JOUR
T1 - Long term sequelae after SARS-CoV-2 infection in children
T2 - a household study
AU - Sluiter-Post, Judith G C
AU - Fourie, Elandri
AU - Wildenbeest, Joanne G
AU - van Lelyveld, Steven F L
AU - Bruijning-Verhagen, Patricia C J L
AU - van Houten, Marianne A
N1 - Funding Information:
We gratefully acknowledge the contribution of the children and parents in this study.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/6/28
Y1 - 2023/6/28
N2 - BACKGROUND: In children persistent symptoms after SARS-CoV-2 infection have been reported, however, duration and characteristics of symptoms in previously healthy children remain unclear. Therefore this study aimed to evaluate persisting symptoms in children at 6 and 12 months after a SARS-CoV-2 infection.METHODS: In this prospective cohort study households with a confirmed SARS-CoV-2 positive outbreak were matched 1:1 to household controls from SARS-CoV-2 negative outbreaks. These households completed questionnaires at 6 and 12 months on the presence and severity of SARS-CoV-2 related symptoms, general well-being/functioning, cognition, persisting symptoms and quality of life.FINDINGS: None of the children who had a SARS-CoV-2 infection during the study reported persistent symptoms at 6 and 12 months after infection, whereas almost 8% of the children with a negative RT-PCR test during the study reported symptoms such as coughing and mild fever, however, no significant differences were found. In addition, for all other outcomes, no differences were observed between the two groups.TAKE HOME MESSAGE: Post-acute sequelae of mild SARS-CoV-2 infections appears to be uncommon in previously healthy children.
AB - BACKGROUND: In children persistent symptoms after SARS-CoV-2 infection have been reported, however, duration and characteristics of symptoms in previously healthy children remain unclear. Therefore this study aimed to evaluate persisting symptoms in children at 6 and 12 months after a SARS-CoV-2 infection.METHODS: In this prospective cohort study households with a confirmed SARS-CoV-2 positive outbreak were matched 1:1 to household controls from SARS-CoV-2 negative outbreaks. These households completed questionnaires at 6 and 12 months on the presence and severity of SARS-CoV-2 related symptoms, general well-being/functioning, cognition, persisting symptoms and quality of life.FINDINGS: None of the children who had a SARS-CoV-2 infection during the study reported persistent symptoms at 6 and 12 months after infection, whereas almost 8% of the children with a negative RT-PCR test during the study reported symptoms such as coughing and mild fever, however, no significant differences were found. In addition, for all other outcomes, no differences were observed between the two groups.TAKE HOME MESSAGE: Post-acute sequelae of mild SARS-CoV-2 infections appears to be uncommon in previously healthy children.
KW - Children
KW - Household
KW - Long term symptoms
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85163603764&partnerID=8YFLogxK
U2 - 10.1186/s12985-023-02094-z
DO - 10.1186/s12985-023-02094-z
M3 - Article
C2 - 37380990
SN - 1743-422X
VL - 20
SP - 1
EP - 5
JO - Virology Journal
JF - Virology Journal
IS - 1
M1 - 137
ER -