Long-term outcome of elderly out-of-hospital cardiac arrest survivors as compared with their younger counterparts and the general population

Bart Hiemstra; Remco Bergman; Anthony R Absalom; Joukje van der Naalt; Pim van der Harst; Ronald de Vos; Wybe Nieuwland; Maarten W Nijsten; Iwan C C van der Horst

doi:10.1177/1753944718792420

Long-term outcome of elderly out-of-hospital cardiac arrest survivors as compared with their younger counterparts and the general population

Bart Hiemstra, Remco Bergman, Anthony R Absalom, Joukje van der Naalt, Pim van der Harst, Ronald de Vos, Wybe Nieuwland, Maarten W Nijsten, Iwan C C van der Horst

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND:: Over the past decade, prehospital and in-hospital treatment for out-of-hospital cardiac arrest (OHCA) has improved considerably. There are sparse data on the long-term outcome, especially in elderly patients. We studied whether elderly patients benefit to the same extent compared with younger patients and at long-term follow up as compared with the general population.

METHODS:: Between 2001 and 2010, data from all patients presented to our hospital after OHCA were recorded. Elderly patients (⩾75 years) were compared with younger patients. Neurological outcome was classified as cerebral performance category (CPC) at hospital discharge and long-term survival was compared with younger patients and predicted survival rates of the general population.

RESULTS:: Of the 810 patients admitted after OHCA, a total of 551 patients (68%) achieved return of spontaneous circulation, including 125 (23%) elderly patients with a mean age of 81 ± 5 years. In-hospital survival was lower in elderly patients compared with younger patients with rates of 33% versus 57% ( p < 0.001). A CPC of 1 was present in 73% of the elderly patients versus 86% of the younger patients ( p = 0.031). In 7.3% of the elderly patients, a CPC >2 was observed versus 2.5% of their younger counterparts ( p = 0.103). Elderly patients had a median survival of 6.5 [95% confidence interval (CI) 2.0-7.9] years compared with 7.7 (95% CI 7.5-7.9) years of the general population ( p = 0.019).

CONCLUSIONS:: The survival rate after OHCA in elderly patients is approximately half that of younger patients. Elderly patients who survive to discharge frequently have favorable neurological outcomes and a long-term survival that approximates that of the general population.

Original language	English
Pages (from-to)	341-349
Number of pages	9
Journal	Therapeutic advances in cardiovascular disease
Volume	12
Issue number	12
DOIs	https://doi.org/10.1177/1753944718792420
Publication status	Published - Dec 2018
Externally published	Yes

Keywords

Age Factors
Aged
Aged, 80 and over
Cardiopulmonary Resuscitation/adverse effects
Female
Hospital Mortality
Humans
Male
Middle Aged
Neurologic Examination
Out-of-Hospital Cardiac Arrest/diagnosis
Patient Discharge
Recovery of Function
Retrospective Studies
Risk Factors
Survival Rate
Survivors
Time Factors
Treatment Outcome

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10.1177/1753944718792420

Cite this

Hiemstra, B., Bergman, R., Absalom, A. R., van der Naalt, J., van der Harst, P., de Vos, R., Nieuwland, W., Nijsten, M. W., & van der Horst, I. C. C. (2018). Long-term outcome of elderly out-of-hospital cardiac arrest survivors as compared with their younger counterparts and the general population. Therapeutic advances in cardiovascular disease, 12(12), 341-349. https://doi.org/10.1177/1753944718792420

@article{d034ec82509848f6b4934c5945dd63aa,

title = "Long-term outcome of elderly out-of-hospital cardiac arrest survivors as compared with their younger counterparts and the general population",

abstract = "BACKGROUND:: Over the past decade, prehospital and in-hospital treatment for out-of-hospital cardiac arrest (OHCA) has improved considerably. There are sparse data on the long-term outcome, especially in elderly patients. We studied whether elderly patients benefit to the same extent compared with younger patients and at long-term follow up as compared with the general population.METHODS:: Between 2001 and 2010, data from all patients presented to our hospital after OHCA were recorded. Elderly patients (⩾75 years) were compared with younger patients. Neurological outcome was classified as cerebral performance category (CPC) at hospital discharge and long-term survival was compared with younger patients and predicted survival rates of the general population.RESULTS:: Of the 810 patients admitted after OHCA, a total of 551 patients (68%) achieved return of spontaneous circulation, including 125 (23%) elderly patients with a mean age of 81 ± 5 years. In-hospital survival was lower in elderly patients compared with younger patients with rates of 33% versus 57% ( p < 0.001). A CPC of 1 was present in 73% of the elderly patients versus 86% of the younger patients ( p = 0.031). In 7.3% of the elderly patients, a CPC >2 was observed versus 2.5% of their younger counterparts ( p = 0.103). Elderly patients had a median survival of 6.5 [95% confidence interval (CI) 2.0-7.9] years compared with 7.7 (95% CI 7.5-7.9) years of the general population ( p = 0.019).CONCLUSIONS:: The survival rate after OHCA in elderly patients is approximately half that of younger patients. Elderly patients who survive to discharge frequently have favorable neurological outcomes and a long-term survival that approximates that of the general population.",

keywords = "Age Factors, Aged, Aged, 80 and over, Cardiopulmonary Resuscitation/adverse effects, Female, Hospital Mortality, Humans, Male, Middle Aged, Neurologic Examination, Out-of-Hospital Cardiac Arrest/diagnosis, Patient Discharge, Recovery of Function, Retrospective Studies, Risk Factors, Survival Rate, Survivors, Time Factors, Treatment Outcome",

author = "Bart Hiemstra and Remco Bergman and Absalom, {Anthony R} and {van der Naalt}, Joukje and {van der Harst}, Pim and {de Vos}, Ronald and Wybe Nieuwland and Nijsten, {Maarten W} and {van der Horst}, {Iwan C C}",

note = "Publisher Copyright: {\textcopyright} The Author(s), 2018.",

year = "2018",

month = dec,

doi = "10.1177/1753944718792420",

language = "English",

volume = "12",

pages = "341--349",

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Hiemstra, B, Bergman, R, Absalom, AR, van der Naalt, J, van der Harst, P, de Vos, R, Nieuwland, W, Nijsten, MW & van der Horst, ICC 2018, 'Long-term outcome of elderly out-of-hospital cardiac arrest survivors as compared with their younger counterparts and the general population', Therapeutic advances in cardiovascular disease, vol. 12, no. 12, pp. 341-349. https://doi.org/10.1177/1753944718792420

Long-term outcome of elderly out-of-hospital cardiac arrest survivors as compared with their younger counterparts and the general population. / Hiemstra, Bart; Bergman, Remco; Absalom, Anthony R et al.
In: Therapeutic advances in cardiovascular disease, Vol. 12, No. 12, 12.2018, p. 341-349.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Long-term outcome of elderly out-of-hospital cardiac arrest survivors as compared with their younger counterparts and the general population

AU - Hiemstra, Bart

AU - Bergman, Remco

AU - Absalom, Anthony R

AU - van der Naalt, Joukje

AU - van der Harst, Pim

AU - de Vos, Ronald

AU - Nieuwland, Wybe

AU - Nijsten, Maarten W

AU - van der Horst, Iwan C C

N1 - Publisher Copyright: © The Author(s), 2018.

PY - 2018/12

Y1 - 2018/12

N2 - BACKGROUND:: Over the past decade, prehospital and in-hospital treatment for out-of-hospital cardiac arrest (OHCA) has improved considerably. There are sparse data on the long-term outcome, especially in elderly patients. We studied whether elderly patients benefit to the same extent compared with younger patients and at long-term follow up as compared with the general population.METHODS:: Between 2001 and 2010, data from all patients presented to our hospital after OHCA were recorded. Elderly patients (⩾75 years) were compared with younger patients. Neurological outcome was classified as cerebral performance category (CPC) at hospital discharge and long-term survival was compared with younger patients and predicted survival rates of the general population.RESULTS:: Of the 810 patients admitted after OHCA, a total of 551 patients (68%) achieved return of spontaneous circulation, including 125 (23%) elderly patients with a mean age of 81 ± 5 years. In-hospital survival was lower in elderly patients compared with younger patients with rates of 33% versus 57% ( p < 0.001). A CPC of 1 was present in 73% of the elderly patients versus 86% of the younger patients ( p = 0.031). In 7.3% of the elderly patients, a CPC >2 was observed versus 2.5% of their younger counterparts ( p = 0.103). Elderly patients had a median survival of 6.5 [95% confidence interval (CI) 2.0-7.9] years compared with 7.7 (95% CI 7.5-7.9) years of the general population ( p = 0.019).CONCLUSIONS:: The survival rate after OHCA in elderly patients is approximately half that of younger patients. Elderly patients who survive to discharge frequently have favorable neurological outcomes and a long-term survival that approximates that of the general population.

AB - BACKGROUND:: Over the past decade, prehospital and in-hospital treatment for out-of-hospital cardiac arrest (OHCA) has improved considerably. There are sparse data on the long-term outcome, especially in elderly patients. We studied whether elderly patients benefit to the same extent compared with younger patients and at long-term follow up as compared with the general population.METHODS:: Between 2001 and 2010, data from all patients presented to our hospital after OHCA were recorded. Elderly patients (⩾75 years) were compared with younger patients. Neurological outcome was classified as cerebral performance category (CPC) at hospital discharge and long-term survival was compared with younger patients and predicted survival rates of the general population.RESULTS:: Of the 810 patients admitted after OHCA, a total of 551 patients (68%) achieved return of spontaneous circulation, including 125 (23%) elderly patients with a mean age of 81 ± 5 years. In-hospital survival was lower in elderly patients compared with younger patients with rates of 33% versus 57% ( p < 0.001). A CPC of 1 was present in 73% of the elderly patients versus 86% of the younger patients ( p = 0.031). In 7.3% of the elderly patients, a CPC >2 was observed versus 2.5% of their younger counterparts ( p = 0.103). Elderly patients had a median survival of 6.5 [95% confidence interval (CI) 2.0-7.9] years compared with 7.7 (95% CI 7.5-7.9) years of the general population ( p = 0.019).CONCLUSIONS:: The survival rate after OHCA in elderly patients is approximately half that of younger patients. Elderly patients who survive to discharge frequently have favorable neurological outcomes and a long-term survival that approximates that of the general population.

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Cardiopulmonary Resuscitation/adverse effects

KW - Female

KW - Hospital Mortality

KW - Humans

KW - Male

KW - Middle Aged

KW - Neurologic Examination

KW - Out-of-Hospital Cardiac Arrest/diagnosis

KW - Patient Discharge

KW - Recovery of Function

KW - Retrospective Studies

KW - Risk Factors

KW - Survival Rate

KW - Survivors

KW - Time Factors

KW - Treatment Outcome

U2 - 10.1177/1753944718792420

DO - 10.1177/1753944718792420

M3 - Article

C2 - 30231773

SN - 1753-9447

VL - 12

SP - 341

EP - 349

JO - Therapeutic advances in cardiovascular disease

JF - Therapeutic advances in cardiovascular disease

IS - 12

ER -

Long-term outcome of elderly out-of-hospital cardiac arrest survivors as compared with their younger counterparts and the general population

Abstract

Keywords

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