TY - JOUR
T1 - Long-term outcome after liver surgery for colorectal metastases in elderly patients
T2 - a nationwide population-based study
AU - van Woerden, Victor
AU - de Graaff, Michelle R.
AU - Elfrink, Arthur K.E.
AU - Grünhagen, Dirk J.
AU - Kok, Niels F.M.
AU - Olde Damink, Steven W.M.
AU - van Dam, Ronald M.
AU - Klaase, Joost M.
AU - Buis, Carlijn I.
AU - Hagendoorn, Jeroen
AU - Verhoef, Cornelis
AU - Hartgrink, Henk H.
AU - Swijnenburg, Rutger Jan
AU - Erdmann, Joris
AU - van den Boezem, Peter B.
AU - Gobardhan, Paul D.
AU - Torrenga, Hans
AU - Liem, Mike S.L.
AU - Leclercq, Wouter K.G.
AU - Bosscha, Koop
AU - Belt, Eric J.T.
AU - Vermaas, Maarten
AU - Kuhlmann, Koert F.D.
AU - Marsman, Hendrik A.
AU - Patijn, Gijsbert A.
AU - Dulk, Marcel den
AU - Oosterling, Steven J.
N1 - Publisher Copyright:
© 2025 The Authors
PY - 2026/2
Y1 - 2026/2
N2 - Background: Age alone is no longer a contraindication for resection of colorectal liver metastases (CRLM). The aim of this study was to compare survival after resection of CRLM across different age groups. Methods: A population-based study of patients who underwent resection of CRLM in the Netherlands between 2014 and 2022 was performed. For survival analyses, data from 2014 to 2018 were used. Patients were divided into three groups: <70, 70–80, and ≥80 years. Main outcomes were overall survival (OS) and relative survival (RS), defined as survival relative to age-matched survival in the general population. Secondary outcomes included short-term postoperative outcome and risk factors influencing survival. Results: Among 6415 patients, 3874 (60.3 %) were <70 years, 2042 (31.8 %) were 70–80, and 499 (7.7 %) were ≥80 years. Median OS was 54.2 months (<70), 47.1 months (70–80), and 40.7 months (≥80). Five-year RS was 51.8 %, 57.9 %, and 64.0 %, respectively. In multivariable analysis, age 70–80 (aHR 1.20) and ≥80 (aHR 1.50) were associated with worse OS. Other independent risk factors included Charlson score ≥2, ASA ≥3, >3 CRLM, largest CRLM >4 cm, synchronous or extrahepatic disease, and major complications. Conclusion: Resection of CRLM in selected elderly patients results in acceptable overall survival.
AB - Background: Age alone is no longer a contraindication for resection of colorectal liver metastases (CRLM). The aim of this study was to compare survival after resection of CRLM across different age groups. Methods: A population-based study of patients who underwent resection of CRLM in the Netherlands between 2014 and 2022 was performed. For survival analyses, data from 2014 to 2018 were used. Patients were divided into three groups: <70, 70–80, and ≥80 years. Main outcomes were overall survival (OS) and relative survival (RS), defined as survival relative to age-matched survival in the general population. Secondary outcomes included short-term postoperative outcome and risk factors influencing survival. Results: Among 6415 patients, 3874 (60.3 %) were <70 years, 2042 (31.8 %) were 70–80, and 499 (7.7 %) were ≥80 years. Median OS was 54.2 months (<70), 47.1 months (70–80), and 40.7 months (≥80). Five-year RS was 51.8 %, 57.9 %, and 64.0 %, respectively. In multivariable analysis, age 70–80 (aHR 1.20) and ≥80 (aHR 1.50) were associated with worse OS. Other independent risk factors included Charlson score ≥2, ASA ≥3, >3 CRLM, largest CRLM >4 cm, synchronous or extrahepatic disease, and major complications. Conclusion: Resection of CRLM in selected elderly patients results in acceptable overall survival.
UR - https://www.scopus.com/pages/publications/105023530943
U2 - 10.1016/j.hpb.2025.10.011
DO - 10.1016/j.hpb.2025.10.011
M3 - Article
C2 - 41314940
AN - SCOPUS:105023530943
SN - 1365-182X
VL - 28
SP - 169
EP - 177
JO - HPB
JF - HPB
IS - 2
ER -