Long-term health-related quality of life after pancreatic resection for malignancy in patients with and without severe postoperative complications

Hanne D Heerkens; Lisanne van Berkel; Dorine S J Tseng; Evelyn M Monninkhof; Hjalmar C van Santvoort; Jeroen Hagendoorn; Inne H M Borel Rinkes; Irene M Lips; Martijn Intven; I Quintus Molenaar

doi:10.1016/j.hpb.2017.09.003

Long-term health-related quality of life after pancreatic resection for malignancy in patients with and without severe postoperative complications

Hanne D Heerkens, Lisanne van Berkel, Dorine S J Tseng, Evelyn M Monninkhof, Hjalmar C van Santvoort, Jeroen Hagendoorn, Inne H M Borel Rinkes, Irene M Lips, Martijn Intven, I Quintus Molenaar

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Surgery for pancreatic cancer yields significant morbidity and mortality risks and survival is limited. Therefore, the influence of complications on quality of life (QoL) after pancreatic surgery is important. This study compares QoL in patients with and without severe complications after surgery for pancreatic (pre-)malignancy.

METHODS: This prospective cohort study scored complications after pancreatic surgery according to the Clavien-Dindo system and the definitions of the International Study Group of Pancreatic Surgery. QoL was measured by the RAND36 questionnaire, the European Organization for Research and Treatment of Cancer core questionnaire (QLQ-C30) and the pancreas specific QLQ-PAN26. QoL in patients with severe complications was compared with QoL in patients with no or mild complications over a period of 12 months. Analysis was performed with linear mixed models for repeated measurements.

RESULTS: Between March 2012 and July 2016, 137 patients were included. Sixty-eight patients (50%) had at least 1 severe complication. There were no statistically significant and clinically relevant differences between both groups in QoL up to 12 months after surgery.

CONCLUSION: In this study, no differences in QoL between patients with and without severe postoperative complications were encountered during the first 12 months after surgery for pancreatic (pre-)malignancy.

TRIAL REGISTRATION: http://www.clinicaltrials.gov Identifier: NCT02175992.

Original language	English
Pages (from-to)	188-195
Number of pages	8
Journal	HPB
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.hpb.2017.09.003
Publication status	Published - 2018

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10.1016/j.hpb.2017.09.003

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Heerkens, H. D., van Berkel, L., Tseng, D. S. J., Monninkhof, E. M., van Santvoort, H. C., Hagendoorn, J., Borel Rinkes, I. H. M., Lips, I. M., Intven, M., & Molenaar, I. Q. (2018). Long-term health-related quality of life after pancreatic resection for malignancy in patients with and without severe postoperative complications. HPB, 20(2), 188-195. https://doi.org/10.1016/j.hpb.2017.09.003

@article{789b97ecf1cf486fb5fa877256636d1c,

title = "Long-term health-related quality of life after pancreatic resection for malignancy in patients with and without severe postoperative complications",

abstract = "BACKGROUND: Surgery for pancreatic cancer yields significant morbidity and mortality risks and survival is limited. Therefore, the influence of complications on quality of life (QoL) after pancreatic surgery is important. This study compares QoL in patients with and without severe complications after surgery for pancreatic (pre-)malignancy.METHODS: This prospective cohort study scored complications after pancreatic surgery according to the Clavien-Dindo system and the definitions of the International Study Group of Pancreatic Surgery. QoL was measured by the RAND36 questionnaire, the European Organization for Research and Treatment of Cancer core questionnaire (QLQ-C30) and the pancreas specific QLQ-PAN26. QoL in patients with severe complications was compared with QoL in patients with no or mild complications over a period of 12 months. Analysis was performed with linear mixed models for repeated measurements.RESULTS: Between March 2012 and July 2016, 137 patients were included. Sixty-eight patients (50%) had at least 1 severe complication. There were no statistically significant and clinically relevant differences between both groups in QoL up to 12 months after surgery.CONCLUSION: In this study, no differences in QoL between patients with and without severe postoperative complications were encountered during the first 12 months after surgery for pancreatic (pre-)malignancy.TRIAL REGISTRATION: http://www.clinicaltrials.gov Identifier: NCT02175992.",

author = "Heerkens, {Hanne D} and {van Berkel}, Lisanne and Tseng, {Dorine S J} and Monninkhof, {Evelyn M} and {van Santvoort}, {Hjalmar C} and Jeroen Hagendoorn and {Borel Rinkes}, {Inne H M} and Lips, {Irene M} and Martijn Intven and Molenaar, {I Quintus}",

note = "Publisher Copyright: {\textcopyright} 2017 International Hepato-Pancreato-Biliary Association Inc.",

year = "2018",

doi = "10.1016/j.hpb.2017.09.003",

language = "English",

volume = "20",

pages = "188--195",

number = "2",

}

Heerkens, HD, van Berkel, L, Tseng, DSJ, Monninkhof, EM , van Santvoort, HC , Hagendoorn, J , Borel Rinkes, IHM, Lips, IM, Intven, M & Molenaar, IQ 2018, 'Long-term health-related quality of life after pancreatic resection for malignancy in patients with and without severe postoperative complications', HPB, vol. 20, no. 2, pp. 188-195. https://doi.org/10.1016/j.hpb.2017.09.003

TY - JOUR

T1 - Long-term health-related quality of life after pancreatic resection for malignancy in patients with and without severe postoperative complications

AU - Heerkens, Hanne D

AU - van Berkel, Lisanne

AU - Tseng, Dorine S J

AU - Monninkhof, Evelyn M

AU - van Santvoort, Hjalmar C

AU - Hagendoorn, Jeroen

AU - Borel Rinkes, Inne H M

AU - Lips, Irene M

AU - Intven, Martijn

AU - Molenaar, I Quintus

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Surgery for pancreatic cancer yields significant morbidity and mortality risks and survival is limited. Therefore, the influence of complications on quality of life (QoL) after pancreatic surgery is important. This study compares QoL in patients with and without severe complications after surgery for pancreatic (pre-)malignancy.METHODS: This prospective cohort study scored complications after pancreatic surgery according to the Clavien-Dindo system and the definitions of the International Study Group of Pancreatic Surgery. QoL was measured by the RAND36 questionnaire, the European Organization for Research and Treatment of Cancer core questionnaire (QLQ-C30) and the pancreas specific QLQ-PAN26. QoL in patients with severe complications was compared with QoL in patients with no or mild complications over a period of 12 months. Analysis was performed with linear mixed models for repeated measurements.RESULTS: Between March 2012 and July 2016, 137 patients were included. Sixty-eight patients (50%) had at least 1 severe complication. There were no statistically significant and clinically relevant differences between both groups in QoL up to 12 months after surgery.CONCLUSION: In this study, no differences in QoL between patients with and without severe postoperative complications were encountered during the first 12 months after surgery for pancreatic (pre-)malignancy.TRIAL REGISTRATION: http://www.clinicaltrials.gov Identifier: NCT02175992.

AB - BACKGROUND: Surgery for pancreatic cancer yields significant morbidity and mortality risks and survival is limited. Therefore, the influence of complications on quality of life (QoL) after pancreatic surgery is important. This study compares QoL in patients with and without severe complications after surgery for pancreatic (pre-)malignancy.METHODS: This prospective cohort study scored complications after pancreatic surgery according to the Clavien-Dindo system and the definitions of the International Study Group of Pancreatic Surgery. QoL was measured by the RAND36 questionnaire, the European Organization for Research and Treatment of Cancer core questionnaire (QLQ-C30) and the pancreas specific QLQ-PAN26. QoL in patients with severe complications was compared with QoL in patients with no or mild complications over a period of 12 months. Analysis was performed with linear mixed models for repeated measurements.RESULTS: Between March 2012 and July 2016, 137 patients were included. Sixty-eight patients (50%) had at least 1 severe complication. There were no statistically significant and clinically relevant differences between both groups in QoL up to 12 months after surgery.CONCLUSION: In this study, no differences in QoL between patients with and without severe postoperative complications were encountered during the first 12 months after surgery for pancreatic (pre-)malignancy.TRIAL REGISTRATION: http://www.clinicaltrials.gov Identifier: NCT02175992.

U2 - 10.1016/j.hpb.2017.09.003

DO - 10.1016/j.hpb.2017.09.003

M3 - Article

C2 - 29092792

SN - 1365-182X

VL - 20

SP - 188

EP - 195

JO - HPB

JF - HPB

IS - 2

ER -

Long-term health-related quality of life after pancreatic resection for malignancy in patients with and without severe postoperative complications

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