TY - JOUR
T1 - Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on cognition in women with high familial risk of ovarian cancer
T2 - A cross-sectional study
AU - Terra, Lara
AU - Lee Meeuw Kjoe, Philippe R.
AU - Agelink van Rentergem, Joost A.
AU - Beekman, Maarten J.
AU - Heemskerk-Gerritsen, Bernadette A.M.
AU - van Beurden, Marc
AU - Roeters van Lennep, Jeanine E.
AU - van Doorn, Helena C.
AU - de Hullu, Joanna A.
AU - Mourits, Marian J.E.
AU - van Dorst, Eleonora B.L.
AU - Mom, Constantijne H.
AU - Slangen, Brigitte F.M.
AU - Gaarenstroom, Katja N.
AU - van der Kolk, Lizet E.
AU - Collée, J. Margriet
AU - Wevers, Marijke R.
AU - Ausems, Margreet G.E.M.
AU - van Engelen, Klaartje
AU - van de Beek, Irma
AU - Berger, Lieke P.V.
AU - van Asperen, Christi J.
AU - Gomez Garcia, Encarna B.
AU - Maas, Angela H.E.M.
AU - Hooning, Maartje J.
AU - van der Wall, Elsken
AU - van Leeuwen, Flora E.
AU - Schagen, Sanne B.
N1 - Funding Information:
The Dutch Cancer Society (KWF) granted funding for this project, registered under grant 10164. This study was peer‐reviewed by the Dutch Cancer Society and several patient panels before granting funding. The funding body had no role in the design of the study, collection, analysis, and interpretation of data or in writing the article.
Publisher Copyright:
© 2023 John Wiley & Sons Ltd.
PY - 2023/7
Y1 - 2023/7
N2 - Objective: To examine the effect of a premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of ovarian cancer on objective and subjective cognition at least 10 years after RRSO. Design: A cross-sectional study with prospective follow-up, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population or Sample: 641 women (66% BRCA1/2 pathogenic variant carriers) who underwent either a premenopausal RRSO ≤ age 45 (n = 436) or a postmenopausal RRSO ≥ age 54 (n = 205). All participants were older than 55 years at recruitment. Methods: Participants completed an online cognitive test battery and a questionnaire on subjective cognition. We used multivariable regression analyses, adjusting for age, education, breast cancer, hormone replacement therapy, cardiovascular risk factors and depression. Main Outcome Measures: The influence of RRSO on objective and subjective cognition of women with a premenopausal RRSO compared with women with a postmenopausal RRSO. Results: After adjustment, women with a premenopausal RRSO (mean time since RRSO 18.2 years) performed similarly on objective cognitive tests compared with women with a postmenopausal RRSO (mean time since RRSO 11.9 years). However, they more frequently reported problems with reasoning (odds ratio [OR] 1.8, 95% confidence interval [95% CI] 1.1–3.1) and multitasking (OR 1.9, 95% CI 1.1–3.4) than women with a postmenopausal RRSO. This difference between groups disappeared in an analysis restricted to women of comparable ages (60–70 years). Conclusions: Reassuringly, approximately 18 years after RRSO, we found no association between premenopausal RRSO and objective cognition.
AB - Objective: To examine the effect of a premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of ovarian cancer on objective and subjective cognition at least 10 years after RRSO. Design: A cross-sectional study with prospective follow-up, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population or Sample: 641 women (66% BRCA1/2 pathogenic variant carriers) who underwent either a premenopausal RRSO ≤ age 45 (n = 436) or a postmenopausal RRSO ≥ age 54 (n = 205). All participants were older than 55 years at recruitment. Methods: Participants completed an online cognitive test battery and a questionnaire on subjective cognition. We used multivariable regression analyses, adjusting for age, education, breast cancer, hormone replacement therapy, cardiovascular risk factors and depression. Main Outcome Measures: The influence of RRSO on objective and subjective cognition of women with a premenopausal RRSO compared with women with a postmenopausal RRSO. Results: After adjustment, women with a premenopausal RRSO (mean time since RRSO 18.2 years) performed similarly on objective cognitive tests compared with women with a postmenopausal RRSO (mean time since RRSO 11.9 years). However, they more frequently reported problems with reasoning (odds ratio [OR] 1.8, 95% confidence interval [95% CI] 1.1–3.1) and multitasking (OR 1.9, 95% CI 1.1–3.4) than women with a postmenopausal RRSO. This difference between groups disappeared in an analysis restricted to women of comparable ages (60–70 years). Conclusions: Reassuringly, approximately 18 years after RRSO, we found no association between premenopausal RRSO and objective cognition.
KW - BRCA1/2 pathogenic variant carriers
KW - cognitive functioning
KW - premature menopause
KW - risk-reducing salpingo-oophorectomy
UR - https://www.scopus.com/pages/publications/85148518713
U2 - 10.1111/1471-0528.17415
DO - 10.1111/1471-0528.17415
M3 - Article
C2 - 36715559
AN - SCOPUS:85148518713
SN - 1470-0328
VL - 130
SP - 968
EP - 977
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 8
ER -