Long-term changes in renal function and perfusion in heart failure patients with reduced ejection fraction

Nicolas F Schroten; Kevin Damman; Mattia A. E. Valente; Tom D. Smilde; Dirk J. van Veldhuisen; Gerjan J. Navis; Carlo A. Gaillard; Adriaan A Voors; Hans L. Hillege

doi:10.1007/s00392-015-0881-9

Long-term changes in renal function and perfusion in heart failure patients with reduced ejection fraction

Nicolas F Schroten, Kevin Damman, Mattia A. E. Valente, Tom D. Smilde, Dirk J. van Veldhuisen, Gerjan J. Navis, Carlo A. Gaillard, Adriaan A Voors, Hans L. Hillege

Divison of Internal Medicine and Dermatology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Little is known about the natural course of renal function and renal hemodynamics in heart failure patients with reduced ejection fraction (HFREF).We prospectively studied effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) in 73 HFREF patients with I-125-iothalamate/I-131-hippuran clearances with a mean follow-up of 34.6 +/- A 4.4 months. Fifteen percent were female, with age 58 +/- A 12 years and left ventricular ejection fraction (LVEF) 29 +/- A 10 %. Baseline GFR was 81 +/- A 23 mL/min/1.73 m(2) and declined 0.6 +/- A 4.7 mL/min/1.73 m(2) per year. Baseline ERPF was 292 +/- A 83 mL/min/1.73 m(2) and declined 4.3 +/- A 19 mL/min/1.73 m(2) per year. Of the baseline variables, older age and high urinary kidney injury molecule-1 were the only variables associated with GFR decline (p

Original language	English
Pages (from-to)	10-16
Number of pages	7
Journal	Clinical Research in Cardiology
Volume	105
Issue number	1
DOIs	https://doi.org/10.1007/s00392-015-0881-9
Publication status	Published - Jan 2016

Keywords

Cardiorenal
Heart failure
Renal blood flow
Kidney
Biomarkers
GLOMERULAR-FILTRATION-RATE
NT-PRO-BNP
TUBULAR DAMAGE
DYSFUNCTION
RISK
IMPAIRMENT
PREDICTORS
THERAPY
DISEASE
IMPACT

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title = "Long-term changes in renal function and perfusion in heart failure patients with reduced ejection fraction",

abstract = "Little is known about the natural course of renal function and renal hemodynamics in heart failure patients with reduced ejection fraction (HFREF).We prospectively studied effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) in 73 HFREF patients with I-125-iothalamate/I-131-hippuran clearances with a mean follow-up of 34.6 +/- A 4.4 months. Fifteen percent were female, with age 58 +/- A 12 years and left ventricular ejection fraction (LVEF) 29 +/- A 10 %. Baseline GFR was 81 +/- A 23 mL/min/1.73 m(2) and declined 0.6 +/- A 4.7 mL/min/1.73 m(2) per year. Baseline ERPF was 292 +/- A 83 mL/min/1.73 m(2) and declined 4.3 +/- A 19 mL/min/1.73 m(2) per year. Of the baseline variables, older age and high urinary kidney injury molecule-1 were the only variables associated with GFR decline (p ",

keywords = "Cardiorenal, Heart failure, Renal blood flow, Kidney, Biomarkers, GLOMERULAR-FILTRATION-RATE, NT-PRO-BNP, TUBULAR DAMAGE, DYSFUNCTION, RISK, IMPAIRMENT, PREDICTORS, THERAPY, DISEASE, IMPACT",

author = "Schroten, {Nicolas F} and Kevin Damman and Valente, {Mattia A. E.} and Smilde, {Tom D.} and {van Veldhuisen}, {Dirk J.} and Navis, {Gerjan J.} and Gaillard, {Carlo A.} and Voors, {Adriaan A} and Hillege, {Hans L.}",

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doi = "10.1007/s00392-015-0881-9",

language = "English",

volume = "105",

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journal = "Clinical Research in Cardiology",

issn = "1861-0684",

publisher = "Springer Science and Business Media Deutschland GmbH",

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T1 - Long-term changes in renal function and perfusion in heart failure patients with reduced ejection fraction

AU - Schroten, Nicolas F

AU - Damman, Kevin

AU - Valente, Mattia A. E.

AU - Smilde, Tom D.

AU - van Veldhuisen, Dirk J.

AU - Navis, Gerjan J.

AU - Gaillard, Carlo A.

AU - Voors, Adriaan A

AU - Hillege, Hans L.

PY - 2016/1

Y1 - 2016/1

N2 - Little is known about the natural course of renal function and renal hemodynamics in heart failure patients with reduced ejection fraction (HFREF).We prospectively studied effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) in 73 HFREF patients with I-125-iothalamate/I-131-hippuran clearances with a mean follow-up of 34.6 +/- A 4.4 months. Fifteen percent were female, with age 58 +/- A 12 years and left ventricular ejection fraction (LVEF) 29 +/- A 10 %. Baseline GFR was 81 +/- A 23 mL/min/1.73 m(2) and declined 0.6 +/- A 4.7 mL/min/1.73 m(2) per year. Baseline ERPF was 292 +/- A 83 mL/min/1.73 m(2) and declined 4.3 +/- A 19 mL/min/1.73 m(2) per year. Of the baseline variables, older age and high urinary kidney injury molecule-1 were the only variables associated with GFR decline (p

AB - Little is known about the natural course of renal function and renal hemodynamics in heart failure patients with reduced ejection fraction (HFREF).We prospectively studied effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) in 73 HFREF patients with I-125-iothalamate/I-131-hippuran clearances with a mean follow-up of 34.6 +/- A 4.4 months. Fifteen percent were female, with age 58 +/- A 12 years and left ventricular ejection fraction (LVEF) 29 +/- A 10 %. Baseline GFR was 81 +/- A 23 mL/min/1.73 m(2) and declined 0.6 +/- A 4.7 mL/min/1.73 m(2) per year. Baseline ERPF was 292 +/- A 83 mL/min/1.73 m(2) and declined 4.3 +/- A 19 mL/min/1.73 m(2) per year. Of the baseline variables, older age and high urinary kidney injury molecule-1 were the only variables associated with GFR decline (p

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KW - Heart failure

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KW - Kidney

KW - Biomarkers

KW - GLOMERULAR-FILTRATION-RATE

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KW - TUBULAR DAMAGE

KW - DYSFUNCTION

KW - RISK

KW - IMPAIRMENT

KW - PREDICTORS

KW - THERAPY

KW - DISEASE

KW - IMPACT

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DO - 10.1007/s00392-015-0881-9

M3 - Article

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VL - 105

SP - 10

EP - 16

JO - Clinical Research in Cardiology

JF - Clinical Research in Cardiology

IS - 1

ER -

Long-term changes in renal function and perfusion in heart failure patients with reduced ejection fraction

Abstract

Keywords

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