TY - JOUR
T1 - Locally weighted transmission/disequilibrium test for genetic association analysis
AU - Hsu, Li
AU - Yu, Xuesong
AU - Houwing-Duistermaat, Jeanine J.
AU - Uh, HW
AU - El Galta, Rachid
AU - Lebrec, Jeremie J.P.
AU - Tang, Hua
PY - 2005/12/30
Y1 - 2005/12/30
N2 - The transmission/disequilibrium test statistic has been used for assessing genetic association in affected-parent trios. In the presence of multiple tightly linked marker loci where local dependency may exist, haplotypes are reconstructed statistically to estimate the joint effects of these markers. In this manuscript, we propose an alternative to the haplotype approach by taking a weighted average of multiple loci, where the weight is proportional to the product of (1-2X recombination fraction) and the linkage disequilibrium between markers. As an illustration, we applied the method to the simulated Aipotu data.
AB - The transmission/disequilibrium test statistic has been used for assessing genetic association in affected-parent trios. In the presence of multiple tightly linked marker loci where local dependency may exist, haplotypes are reconstructed statistically to estimate the joint effects of these markers. In this manuscript, we propose an alternative to the haplotype approach by taking a weighted average of multiple loci, where the weight is proportional to the product of (1-2X recombination fraction) and the linkage disequilibrium between markers. As an illustration, we applied the method to the simulated Aipotu data.
UR - http://www.scopus.com/inward/record.url?scp=30344479025&partnerID=8YFLogxK
U2 - 10.1186/1471-2156-6-S1-S60
DO - 10.1186/1471-2156-6-S1-S60
M3 - Article
C2 - 16451673
AN - SCOPUS:30344479025
SN - 1471-2156
VL - 6
JO - BMC Genetics
JF - BMC Genetics
IS - SUPPL.1
M1 - S60
ER -