Local prevalence of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae intestinal carriers at admission and co-expression of ESBL and OXA-48 carbapenemase in Klebsiella pneumoniae: A prevalence survey in a Spanish University Hospital

Diaz Agero Cristina*, Nieves López-Fresneña, Angela L. Rincon Carlavilla, Marta Hernandez Garcia, Patricia Ruiz-Garbajosa, Jesús María Aranaz-Andrés, Friederike Maechler, Petra Gastmeier, Marc J.M. Bonten, Rafael Canton

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective To assess the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) faecal carriers at admission in a University Hospital in Spain. Design Prevalence survey. Setting Pneumology, gastroenterology, urology and neurosurgery units at a university tertiary hospital in Madrid (Spain). Participants A total of 10 643 patients aged 18 and older admitted from March 2014 to April 2016 with a rectal swab taken at admission or as soon as possible within the first 48 hours. Primary and secondary outcome measures Prevalence of ESBL-E faecal carriers and prevalence of ESBL-E infections at admission. Results The prevalance of ESBL-E carriers at admission was 7.69% (CI 95% 7.18 to 8.19). Most of the isolates were Escherichia coli (77.51%), followed by Klebsiella pneumoniae (20.71%). Eighty-eight (10.41%) of ESBL-E were simultaneous ESBL and carbapenemase (CP) producers, 1.83% in the case of E. coli and 42.86% among K. pneumoniae isolates. Of the ESBL typed, 52.15% belonged to the cefotaximases (CTX-M-15) type and 91.38% of the CP were oxacillinase (OXA-48) type. Only 0.43% patients presented an active infection by ESBL-E at admission. Conclusions The prevalence found in our study is very similar to that found in literature. However, we found a high percentage of simultaneous ESBL and CP producers, particularly in K. pneumoniae. Despite the high prevalence of colonised patients, the ESBL-infection rate at admission was very low.

Original languageEnglish
Article number024879
JournalBMJ Open
Volume9
Issue number3
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • carbapenemase producing enterobacteriaceae
  • extended-spectrum beta-lactamase producing enterobacteriaceae
  • prevalence
  • surveillance

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