Live births after Asherman syndrome treatment

Miriam M F Hanstede; Eva van der Meij; Sebastiaan Veersema; Mark Hans Emanuel

doi:10.1016/j.fertnstert.2021.05.099

Live births after Asherman syndrome treatment

Miriam M F Hanstede, Eva van der Meij, Sebastiaan Veersema, Mark Hans Emanuel

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To study the reproductive outcomes after surgical management of women with Asherman syndrome (AS).

DESIGN: Cohort study.

SETTING: International referral hospital for women with AS.

PATIENT(S): A total of 500 women who were diagnosed with and treated for AS between January 2003 and December 2016 and followed for a minimum of 2 years.

INTERVENTION(S): Hysteroscopic adhesiolysis using conventional instruments with concomitant fluoroscopy as a guidance method.

MAIN OUTCOME MEASURE(S): Live birth rate.

RESULT(S): Of the 500 women included in the cohort, 569 pregnancies were achieved within 3 years after surgery. The miscarriage rate was 33.0%, and the live birth rate was 67.4%. Age, the causal procedure, and at least one miscarriage after adhesiolysis strongly predicted the outcome of a live birth.

CONCLUSION(S): The overall take-home newborn rate was 67.4% after adhesiolysis in women with AS. Women with AS who are relatively young, with a first-trimester procedure preceding AS, and with low grades of adhesions and no miscarriage after adhesiolysis have the best chance of a newborn delivery.

Original language	English
Pages (from-to)	1181-1187
Number of pages	7
Journal	Fertility and Sterility
Volume	116
Issue number	4
DOIs	https://doi.org/10.1016/j.fertnstert.2021.05.099
Publication status	Published - Oct 2021

Keywords

Asherman syndrome
hysteroscopy
live birth rate
pregnancy

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10.1016/j.fertnstert.2021.05.099

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@article{ed0dc57417774827a1c89ab62d95793e,

title = "Live births after Asherman syndrome treatment",

abstract = "OBJECTIVE: To study the reproductive outcomes after surgical management of women with Asherman syndrome (AS).DESIGN: Cohort study.SETTING: International referral hospital for women with AS.PATIENT(S): A total of 500 women who were diagnosed with and treated for AS between January 2003 and December 2016 and followed for a minimum of 2 years.INTERVENTION(S): Hysteroscopic adhesiolysis using conventional instruments with concomitant fluoroscopy as a guidance method.MAIN OUTCOME MEASURE(S): Live birth rate.RESULT(S): Of the 500 women included in the cohort, 569 pregnancies were achieved within 3 years after surgery. The miscarriage rate was 33.0%, and the live birth rate was 67.4%. Age, the causal procedure, and at least one miscarriage after adhesiolysis strongly predicted the outcome of a live birth.CONCLUSION(S): The overall take-home newborn rate was 67.4% after adhesiolysis in women with AS. Women with AS who are relatively young, with a first-trimester procedure preceding AS, and with low grades of adhesions and no miscarriage after adhesiolysis have the best chance of a newborn delivery.",

keywords = "Asherman syndrome, hysteroscopy, live birth rate, pregnancy",

author = "Hanstede, {Miriam M F} and {van der Meij}, Eva and Sebastiaan Veersema and Emanuel, {Mark Hans}",

note = "Funding Information: The study was supported by the Spaarne Gasthuis Hospital since 2019. Publisher Copyright: {\textcopyright} 2021 American Society for Reproductive Medicine",

year = "2021",

month = oct,

doi = "10.1016/j.fertnstert.2021.05.099",

language = "English",

volume = "116",

pages = "1181--1187",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier",

number = "4",

}

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T1 - Live births after Asherman syndrome treatment

AU - Hanstede, Miriam M F

AU - van der Meij, Eva

AU - Veersema, Sebastiaan

AU - Emanuel, Mark Hans

PY - 2021/10

Y1 - 2021/10

N2 - OBJECTIVE: To study the reproductive outcomes after surgical management of women with Asherman syndrome (AS).DESIGN: Cohort study.SETTING: International referral hospital for women with AS.PATIENT(S): A total of 500 women who were diagnosed with and treated for AS between January 2003 and December 2016 and followed for a minimum of 2 years.INTERVENTION(S): Hysteroscopic adhesiolysis using conventional instruments with concomitant fluoroscopy as a guidance method.MAIN OUTCOME MEASURE(S): Live birth rate.RESULT(S): Of the 500 women included in the cohort, 569 pregnancies were achieved within 3 years after surgery. The miscarriage rate was 33.0%, and the live birth rate was 67.4%. Age, the causal procedure, and at least one miscarriage after adhesiolysis strongly predicted the outcome of a live birth.CONCLUSION(S): The overall take-home newborn rate was 67.4% after adhesiolysis in women with AS. Women with AS who are relatively young, with a first-trimester procedure preceding AS, and with low grades of adhesions and no miscarriage after adhesiolysis have the best chance of a newborn delivery.

AB - OBJECTIVE: To study the reproductive outcomes after surgical management of women with Asherman syndrome (AS).DESIGN: Cohort study.SETTING: International referral hospital for women with AS.PATIENT(S): A total of 500 women who were diagnosed with and treated for AS between January 2003 and December 2016 and followed for a minimum of 2 years.INTERVENTION(S): Hysteroscopic adhesiolysis using conventional instruments with concomitant fluoroscopy as a guidance method.MAIN OUTCOME MEASURE(S): Live birth rate.RESULT(S): Of the 500 women included in the cohort, 569 pregnancies were achieved within 3 years after surgery. The miscarriage rate was 33.0%, and the live birth rate was 67.4%. Age, the causal procedure, and at least one miscarriage after adhesiolysis strongly predicted the outcome of a live birth.CONCLUSION(S): The overall take-home newborn rate was 67.4% after adhesiolysis in women with AS. Women with AS who are relatively young, with a first-trimester procedure preceding AS, and with low grades of adhesions and no miscarriage after adhesiolysis have the best chance of a newborn delivery.

KW - Asherman syndrome

KW - hysteroscopy

KW - live birth rate

KW - pregnancy

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U2 - 10.1016/j.fertnstert.2021.05.099

DO - 10.1016/j.fertnstert.2021.05.099

M3 - Article

C2 - 34130799

SN - 0015-0282

VL - 116

SP - 1181

EP - 1187

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 4

ER -

Live births after Asherman syndrome treatment

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