Lithium use and the risk of fractures

I. Wilting; F. de Vries; M.K.S. Thio Brahm; C. Cooper; E.R. Heerdink; H.G.M. Leufkens; W.A. Nolen; A.C.G. Egberts; T.P. van Staa

doi:10.1016/j.bone.2006.12.055

Lithium use and the risk of fractures

I. Wilting, F. de Vries, M.K.S. Thio Brahm, C. Cooper, E.R. Heerdink, H.G.M. Leufkens, W.A. Nolen, A.C.G. Egberts, T.P. van Staa

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use. (c) 2007 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	1252-1258
Number of pages	7
Journal	Bone
Volume	40
Issue number	5
DOIs	https://doi.org/10.1016/j.bone.2006.12.055
Publication status	Published - May 2007

Keywords

fractures
lithium
mania
depression
PRACTICE RESEARCH DATABASE
MESENCHYMAL STEM-CELLS
PARATHYROID-HORMONE
BIPOLAR DISORDER
SUICIDE RISK
HIP FRACTURE
LONG-TERM
DISCONTINUATION
CARBONATE
DIFFERENTIATION

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title = "Lithium use and the risk of fractures",

abstract = "A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use. (c) 2007 Elsevier Inc. All rights reserved.",

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author = "I. Wilting and {de Vries}, F. and {Thio Brahm}, M.K.S. and C. Cooper and E.R. Heerdink and H.G.M. Leufkens and W.A. Nolen and A.C.G. Egberts and {van Staa}, T.P.",

year = "2007",

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AU - Wilting, I.

AU - de Vries, F.

AU - Thio Brahm, M.K.S.

AU - Cooper, C.

AU - Heerdink, E.R.

AU - Leufkens, H.G.M.

AU - Nolen, W.A.

AU - Egberts, A.C.G.

AU - van Staa, T.P.

PY - 2007/5

Y1 - 2007/5

N2 - A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use. (c) 2007 Elsevier Inc. All rights reserved.

AB - A recent study reported a decreased risk of fractures among lithium users. We conducted a case-control study within the UK General Practice Research Database, comparing never, ever, current, recent and past lithium use in 231,778 fracture cases to matched controls. In addition, the risk of fractures was assessed in relation to cumulative duration of use and time since discontinuation. Current use of lithium was associated with a decreased risk of fractures (adjusted odds ratio [OR]=0.75, 95% confidence interval [CI]=0.64-0.88), which did not vary with cumulative duration of use. Among past users an increased risk of fractures was observed (adjusted OR=1.35, 95% CI=1.01-1.79), increasing with time since discontinuation. Our results support the role of the underlying mental disorders in the aetiology of fractures and do not support a pharmacological effect of lithium based on lack of an association with cumulative duration of use. (c) 2007 Elsevier Inc. All rights reserved.

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KW - depression

KW - PRACTICE RESEARCH DATABASE

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KW - BIPOLAR DISORDER

KW - SUICIDE RISK

KW - HIP FRACTURE

KW - LONG-TERM

KW - DISCONTINUATION

KW - CARBONATE

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DO - 10.1016/j.bone.2006.12.055

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JO - Bone

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ER -

Lithium use and the risk of fractures

Abstract

Keywords

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