TY - JOUR
T1 - Lipid accumulation in adipose tissue-resident iNKT cells contributes to an inflammatory phenotype
AU - Morris, Imogen
AU - Vrieling, Frank
AU - Bouwman, Annemieke
AU - Stienstra, Rinke
AU - Kalkhoven, Eric
N1 - Publisher Copyright:
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2024/12
Y1 - 2024/12
N2 - Reciprocal communication between adipocytes and immune cells is essential to maintain optimal adipose tissue (AT) functionality. Amongst others, adipocytes directly interact with invariant NKT cells (iNKT cells), which in turn secrete various cytokines. A lipid-rich microenvironment, as observed in obesity, skews this adipocyte-driven cytokine output towards a more inflammatory output. Whether a lipid-rich microenvironment also affects iNKT cells directly, however, is unknown. Here, we show that primary mouse iNKT cells isolated from AT can accumulate lipids in lipid droplets (LDs), more so than liver- and spleen-resident iNKT cells. Furthermore, a lipid-rich microenvironment increased the production of the proinflammatory cytokine IFNγ. Next, to an indirect, adipocyte-mediated cue, iNKT cells can directly respond to environmental lipid changes, supporting a potential role as nutrient sensors.
AB - Reciprocal communication between adipocytes and immune cells is essential to maintain optimal adipose tissue (AT) functionality. Amongst others, adipocytes directly interact with invariant NKT cells (iNKT cells), which in turn secrete various cytokines. A lipid-rich microenvironment, as observed in obesity, skews this adipocyte-driven cytokine output towards a more inflammatory output. Whether a lipid-rich microenvironment also affects iNKT cells directly, however, is unknown. Here, we show that primary mouse iNKT cells isolated from AT can accumulate lipids in lipid droplets (LDs), more so than liver- and spleen-resident iNKT cells. Furthermore, a lipid-rich microenvironment increased the production of the proinflammatory cytokine IFNγ. Next, to an indirect, adipocyte-mediated cue, iNKT cells can directly respond to environmental lipid changes, supporting a potential role as nutrient sensors.
KW - adipose tissue
KW - inflammation
KW - iNKT cell
KW - lipid droplet
KW - lipids
UR - http://www.scopus.com/inward/record.url?scp=85208790634&partnerID=8YFLogxK
U2 - 10.1080/21623945.2024.2421750
DO - 10.1080/21623945.2024.2421750
M3 - Article
C2 - 39484712
AN - SCOPUS:85208790634
SN - 2162-3945
VL - 13
JO - Adipocyte
JF - Adipocyte
IS - 1
M1 - 2421750
ER -