Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial

Vincent G Haver; Minke H T Hartman; Irene Mateo Leach; Erik Lipsic; Chris P Lexis; Dirk J van Veldhuisen; Wiek H van Gilst; Iwan C van der Horst; Pim van der Harst

doi:10.1007/s00392-015-0848-x

Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial

Vincent G Haver, Minke H T Hartman, Irene Mateo Leach, Erik Lipsic, Chris P Lexis, Dirk J van Veldhuisen, Wiek H van Gilst, Iwan C van der Horst, Pim van der Harst

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Telomere length has been associated with coronary artery disease and heart failure. We studied whether leukocyte telomere length is associated with left ventricular ejection fraction (LVEF) after ST-elevation myocardial infarction (STEMI).

METHODS AND RESULTS: Leukocyte telomere length (LTL) was determined using the monochrome multiplex quantitative PCR method in 353 patients participating in the glycometabolic intervention as adjunct to primary percutaneous coronary intervention in STEMI III trial. LVEF was assessed by magnetic resonance imaging. The mean age of patients was 58.9 ± 11.6 years, 75 % were male. In age- and gender-adjusted models, LTL at baseline was significantly associated with age (beta ± standard error; -0.33 ± 0.01; P < 0.01), gender (0.15 ± 0.03; P < 0.01), TIMI flow pre-PCI (0.05 ± 0.03; P < 0.01), TIMI flow post-PCI (0.03 ± 0.04; P < 0.01), myocardial blush grade (-0.05 ± 0.07; P < 0.01), serum glucose levels (-0.11 ± 0.01; P = 0.03), and total leukocyte count (-0.11 ± 0.01; P = 0.04). At 4 months after STEMI, LVEF was well preserved (54.1 ± 8.4 %) and was not associated with baseline LTL (P = 0.95). Baseline LTL was associated with n-terminal pro-brain natriuretic peptide (NT-proBNP) at 4 months (-0.14 ± 0.01; P = 0.02), albeit not independent for age and gender.

CONCLUSION: Our study does not support a role for LTL as a causal factor related to left ventricular ejection fraction after STEMI.

Original language	English
Pages (from-to)	812-21
Number of pages	10
Journal	Clinical Research in Cardiology
Volume	104
Issue number	10
DOIs	https://doi.org/10.1007/s00392-015-0848-x
Publication status	Published - Oct 2015
Externally published	Yes

Keywords

Acute Disease
Causality
Combined Modality Therapy
Comorbidity
Double-Blind Method
Female
Genetic Predisposition to Disease/epidemiology
Humans
Hypoglycemic Agents/therapeutic use
Incidence
Leukocytes
Longitudinal Studies
Male
Metformin/therapeutic use
Middle Aged
Myocardial Infarction/epidemiology
Netherlands/epidemiology
Percutaneous Coronary Intervention/statistics & numerical data
Placebo Effect
Risk Assessment
Telomere Shortening/genetics
Treatment Outcome
Ventricular Dysfunction, Left/epidemiology

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Haver, V. G., Hartman, M. H. T., Mateo Leach, I., Lipsic, E., Lexis, C. P., van Veldhuisen, D. J., van Gilst, W. H., van der Horst, I. C., & van der Harst, P. (2015). Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial. Clinical Research in Cardiology, 104(10), 812-21. https://doi.org/10.1007/s00392-015-0848-x

Haver, Vincent G ; Hartman, Minke H T ; Mateo Leach, Irene et al. / Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction : data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial. In: Clinical Research in Cardiology. 2015 ; Vol. 104, No. 10. pp. 812-21.

@article{24fb6dcc23894f9a847bc069d819f1eb,

title = "Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial",

abstract = "BACKGROUND: Telomere length has been associated with coronary artery disease and heart failure. We studied whether leukocyte telomere length is associated with left ventricular ejection fraction (LVEF) after ST-elevation myocardial infarction (STEMI).METHODS AND RESULTS: Leukocyte telomere length (LTL) was determined using the monochrome multiplex quantitative PCR method in 353 patients participating in the glycometabolic intervention as adjunct to primary percutaneous coronary intervention in STEMI III trial. LVEF was assessed by magnetic resonance imaging. The mean age of patients was 58.9 ± 11.6 years, 75 % were male. In age- and gender-adjusted models, LTL at baseline was significantly associated with age (beta ± standard error; -0.33 ± 0.01; P < 0.01), gender (0.15 ± 0.03; P < 0.01), TIMI flow pre-PCI (0.05 ± 0.03; P < 0.01), TIMI flow post-PCI (0.03 ± 0.04; P < 0.01), myocardial blush grade (-0.05 ± 0.07; P < 0.01), serum glucose levels (-0.11 ± 0.01; P = 0.03), and total leukocyte count (-0.11 ± 0.01; P = 0.04). At 4 months after STEMI, LVEF was well preserved (54.1 ± 8.4 %) and was not associated with baseline LTL (P = 0.95). Baseline LTL was associated with n-terminal pro-brain natriuretic peptide (NT-proBNP) at 4 months (-0.14 ± 0.01; P = 0.02), albeit not independent for age and gender.CONCLUSION: Our study does not support a role for LTL as a causal factor related to left ventricular ejection fraction after STEMI.",

keywords = "Acute Disease, Causality, Combined Modality Therapy, Comorbidity, Double-Blind Method, Female, Genetic Predisposition to Disease/epidemiology, Humans, Hypoglycemic Agents/therapeutic use, Incidence, Leukocytes, Longitudinal Studies, Male, Metformin/therapeutic use, Middle Aged, Myocardial Infarction/epidemiology, Netherlands/epidemiology, Percutaneous Coronary Intervention/statistics & numerical data, Placebo Effect, Risk Assessment, Telomere Shortening/genetics, Treatment Outcome, Ventricular Dysfunction, Left/epidemiology",

author = "Haver, {Vincent G} and Hartman, {Minke H T} and {Mateo Leach}, Irene and Erik Lipsic and Lexis, {Chris P} and {van Veldhuisen}, {Dirk J} and {van Gilst}, {Wiek H} and {van der Horst}, {Iwan C} and {van der Harst}, Pim",

year = "2015",

month = oct,

doi = "10.1007/s00392-015-0848-x",

language = "English",

volume = "104",

pages = "812--21",

journal = "Clinical Research in Cardiology",

issn = "1861-0684",

publisher = "Taylor and Francis Ltd.",

number = "10",

}

Haver, VG, Hartman, MHT, Mateo Leach, I, Lipsic, E, Lexis, CP, van Veldhuisen, DJ, van Gilst, WH, van der Horst, IC & van der Harst, P 2015, 'Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial', Clinical Research in Cardiology, vol. 104, no. 10, pp. 812-21. https://doi.org/10.1007/s00392-015-0848-x

Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial. / Haver, Vincent G; Hartman, Minke H T; Mateo Leach, Irene et al.
In: Clinical Research in Cardiology, Vol. 104, No. 10, 10.2015, p. 812-21.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction

T2 - data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial

AU - Haver, Vincent G

AU - Hartman, Minke H T

AU - Mateo Leach, Irene

AU - Lipsic, Erik

AU - Lexis, Chris P

AU - van Veldhuisen, Dirk J

AU - van Gilst, Wiek H

AU - van der Horst, Iwan C

AU - van der Harst, Pim

PY - 2015/10

Y1 - 2015/10

N2 - BACKGROUND: Telomere length has been associated with coronary artery disease and heart failure. We studied whether leukocyte telomere length is associated with left ventricular ejection fraction (LVEF) after ST-elevation myocardial infarction (STEMI).METHODS AND RESULTS: Leukocyte telomere length (LTL) was determined using the monochrome multiplex quantitative PCR method in 353 patients participating in the glycometabolic intervention as adjunct to primary percutaneous coronary intervention in STEMI III trial. LVEF was assessed by magnetic resonance imaging. The mean age of patients was 58.9 ± 11.6 years, 75 % were male. In age- and gender-adjusted models, LTL at baseline was significantly associated with age (beta ± standard error; -0.33 ± 0.01; P < 0.01), gender (0.15 ± 0.03; P < 0.01), TIMI flow pre-PCI (0.05 ± 0.03; P < 0.01), TIMI flow post-PCI (0.03 ± 0.04; P < 0.01), myocardial blush grade (-0.05 ± 0.07; P < 0.01), serum glucose levels (-0.11 ± 0.01; P = 0.03), and total leukocyte count (-0.11 ± 0.01; P = 0.04). At 4 months after STEMI, LVEF was well preserved (54.1 ± 8.4 %) and was not associated with baseline LTL (P = 0.95). Baseline LTL was associated with n-terminal pro-brain natriuretic peptide (NT-proBNP) at 4 months (-0.14 ± 0.01; P = 0.02), albeit not independent for age and gender.CONCLUSION: Our study does not support a role for LTL as a causal factor related to left ventricular ejection fraction after STEMI.

AB - BACKGROUND: Telomere length has been associated with coronary artery disease and heart failure. We studied whether leukocyte telomere length is associated with left ventricular ejection fraction (LVEF) after ST-elevation myocardial infarction (STEMI).METHODS AND RESULTS: Leukocyte telomere length (LTL) was determined using the monochrome multiplex quantitative PCR method in 353 patients participating in the glycometabolic intervention as adjunct to primary percutaneous coronary intervention in STEMI III trial. LVEF was assessed by magnetic resonance imaging. The mean age of patients was 58.9 ± 11.6 years, 75 % were male. In age- and gender-adjusted models, LTL at baseline was significantly associated with age (beta ± standard error; -0.33 ± 0.01; P < 0.01), gender (0.15 ± 0.03; P < 0.01), TIMI flow pre-PCI (0.05 ± 0.03; P < 0.01), TIMI flow post-PCI (0.03 ± 0.04; P < 0.01), myocardial blush grade (-0.05 ± 0.07; P < 0.01), serum glucose levels (-0.11 ± 0.01; P = 0.03), and total leukocyte count (-0.11 ± 0.01; P = 0.04). At 4 months after STEMI, LVEF was well preserved (54.1 ± 8.4 %) and was not associated with baseline LTL (P = 0.95). Baseline LTL was associated with n-terminal pro-brain natriuretic peptide (NT-proBNP) at 4 months (-0.14 ± 0.01; P = 0.02), albeit not independent for age and gender.CONCLUSION: Our study does not support a role for LTL as a causal factor related to left ventricular ejection fraction after STEMI.

KW - Acute Disease

KW - Causality

KW - Combined Modality Therapy

KW - Comorbidity

KW - Double-Blind Method

KW - Female

KW - Genetic Predisposition to Disease/epidemiology

KW - Humans

KW - Hypoglycemic Agents/therapeutic use

KW - Incidence

KW - Leukocytes

KW - Longitudinal Studies

KW - Male

KW - Metformin/therapeutic use

KW - Middle Aged

KW - Myocardial Infarction/epidemiology

KW - Netherlands/epidemiology

KW - Percutaneous Coronary Intervention/statistics & numerical data

KW - Placebo Effect

KW - Risk Assessment

KW - Telomere Shortening/genetics

KW - Treatment Outcome

KW - Ventricular Dysfunction, Left/epidemiology

U2 - 10.1007/s00392-015-0848-x

DO - 10.1007/s00392-015-0848-x

M3 - Article

C2 - 25840550

SN - 1861-0684

VL - 104

SP - 812

EP - 821

JO - Clinical Research in Cardiology

JF - Clinical Research in Cardiology

IS - 10

ER -

Haver VG, Hartman MHT, Mateo Leach I, Lipsic E, Lexis CP, van Veldhuisen DJ et al. Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial. Clinical Research in Cardiology. 2015 Oct;104(10):812-21. doi: 10.1007/s00392-015-0848-x