Less severe retinopathy of prematurity induced by surfactant replacement therapy

J. Termote; N. E. Schalij-Delfos; B. P. Cats; D. Wittebol-Post; B. R. Hoogervorst; Haa Brouwers

doi:10.1111/j.1651-2227.1996.tb13958.x

Less severe retinopathy of prematurity induced by surfactant replacement therapy

J. Termote^*, N. E. Schalij-Delfos, B. P. Cats, D. Wittebol-Post, B. R. Hoogervorst, Haa Brouwers

^*Corresponding author for this work

Birth Center Neonatology - Medical

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

To assess the effect of surfactant replacement therapy (SRT) on the prevalence and severity of retinopathy of prematurity (ROP), we compared data from 160 SRT-treated preterm infants with data from 230 historic controls. The prevalence of ROP was 30.6% in the treatment group and 23.4% in the control group. Severe ROP (stages 3-4) was seen in 6.1% of the infants with ROP in the treatment group and 20.3% of the ROP patients in the control group. Surfactant therapy had no influence on the prevalence of ROP (odds ratio 1.4, 95% confidence interval 0.797-2.459, p = 0.242). However, SRT was associated with a decreased risk for severe ROP, compared to mild ROP (odds ratio 0.226, 95% confidence interval 0.056-0.905, p = 0.036). These data suggest that SRT is associated with a decreased risk for severe ROP.

Original language	English
Pages (from-to)	1491-1496
Number of pages	6
Journal	Acta Paediatrica, International Journal of Paediatrics
Volume	85
Issue number	12
DOIs	https://doi.org/10.1111/j.1651-2227.1996.tb13958.x
Publication status	Published - 1996

Keywords

pulmonary surfactants
respiratory distress syndrome
retinopathy of prematurity

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10.1111/j.1651-2227.1996.tb13958.x

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title = "Less severe retinopathy of prematurity induced by surfactant replacement therapy",

abstract = "To assess the effect of surfactant replacement therapy (SRT) on the prevalence and severity of retinopathy of prematurity (ROP), we compared data from 160 SRT-treated preterm infants with data from 230 historic controls. The prevalence of ROP was 30.6\% in the treatment group and 23.4\% in the control group. Severe ROP (stages 3-4) was seen in 6.1\% of the infants with ROP in the treatment group and 20.3\% of the ROP patients in the control group. Surfactant therapy had no influence on the prevalence of ROP (odds ratio 1.4, 95\% confidence interval 0.797-2.459, p = 0.242). However, SRT was associated with a decreased risk for severe ROP, compared to mild ROP (odds ratio 0.226, 95\% confidence interval 0.056-0.905, p = 0.036). These data suggest that SRT is associated with a decreased risk for severe ROP.",

keywords = "pulmonary surfactants, respiratory distress syndrome, retinopathy of prematurity",

author = "J. Termote and Schalij-Delfos, \{N. E.\} and Cats, \{B. P.\} and D. Wittebol-Post and Hoogervorst, \{B. R.\} and Haa Brouwers",

year = "1996",

doi = "10.1111/j.1651-2227.1996.tb13958.x",

language = "English",

volume = "85",

pages = "1491--1496",

journal = "Acta Paediatrica, International Journal of Paediatrics",

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TY - JOUR

T1 - Less severe retinopathy of prematurity induced by surfactant replacement therapy

AU - Termote, J.

AU - Schalij-Delfos, N. E.

AU - Cats, B. P.

AU - Wittebol-Post, D.

AU - Hoogervorst, B. R.

AU - Brouwers, Haa

PY - 1996

Y1 - 1996

N2 - To assess the effect of surfactant replacement therapy (SRT) on the prevalence and severity of retinopathy of prematurity (ROP), we compared data from 160 SRT-treated preterm infants with data from 230 historic controls. The prevalence of ROP was 30.6% in the treatment group and 23.4% in the control group. Severe ROP (stages 3-4) was seen in 6.1% of the infants with ROP in the treatment group and 20.3% of the ROP patients in the control group. Surfactant therapy had no influence on the prevalence of ROP (odds ratio 1.4, 95% confidence interval 0.797-2.459, p = 0.242). However, SRT was associated with a decreased risk for severe ROP, compared to mild ROP (odds ratio 0.226, 95% confidence interval 0.056-0.905, p = 0.036). These data suggest that SRT is associated with a decreased risk for severe ROP.

AB - To assess the effect of surfactant replacement therapy (SRT) on the prevalence and severity of retinopathy of prematurity (ROP), we compared data from 160 SRT-treated preterm infants with data from 230 historic controls. The prevalence of ROP was 30.6% in the treatment group and 23.4% in the control group. Severe ROP (stages 3-4) was seen in 6.1% of the infants with ROP in the treatment group and 20.3% of the ROP patients in the control group. Surfactant therapy had no influence on the prevalence of ROP (odds ratio 1.4, 95% confidence interval 0.797-2.459, p = 0.242). However, SRT was associated with a decreased risk for severe ROP, compared to mild ROP (odds ratio 0.226, 95% confidence interval 0.056-0.905, p = 0.036). These data suggest that SRT is associated with a decreased risk for severe ROP.

KW - pulmonary surfactants

KW - respiratory distress syndrome

KW - retinopathy of prematurity

UR - https://www.scopus.com/pages/publications/0029825128

U2 - 10.1111/j.1651-2227.1996.tb13958.x

DO - 10.1111/j.1651-2227.1996.tb13958.x

M3 - Article

C2 - 9001664

AN - SCOPUS:0029825128

SN - 0803-5253

VL - 85

SP - 1491

EP - 1496

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

IS - 12

ER -

Less severe retinopathy of prematurity induced by surfactant replacement therapy

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Keywords

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