Left ventricular function and exercise capacity after arterial switch operation for transposition of the great arteries: a systematic review and meta-analysis

Sebastiaan W van Wijk; Mieke M Driessen; Folkert J Meijboom; Pieter A Doevendans; Paul H Schoof; Hans M Breur; Tim Takken

doi:10.1017/S1047951117001032

Left ventricular function and exercise capacity after arterial switch operation for transposition of the great arteries: a systematic review and meta-analysis

Sebastiaan W van Wijk, Mieke M Driessen, Folkert J Meijboom, Pieter A Doevendans, Paul H Schoof, Hans M Breur, Tim Takken

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The arterial switch operation for transposition of the great arteries was initially believed to be an anatomical correction. Recent evidence shows reduced exercise capacity and left ventricular function in varying degrees in the long term after an arterial switch operation.

OBJECTIVE: To perform a meta-analysis on long-term exercise capacity and left ventricular ejection fraction after an arterial switch operation.

METHODS: A literature search was performed to cover all studies on patients who had undergone a minimum of 6 years of follow-up that reported either left ventricular ejection fraction, peak oxygen uptake, peak workload, and/or peak heart rate. A meta-analysis was performed if more than three studies reported the outcome of interest.

RESULTS: A total of 21 studies reported on the outcomes of interest. Oxygen uptake was consistently lower in patients who had undergone an arterial switch operation compared with healthy controls, with a pooled average peak oxygen uptake of 87.5±2.9% of predicted. The peak heart rate was also lower compared with that of controls, at 92±2% of predicted. Peak workload was significantly reduced in two studies. Pooled left ventricular ejection fraction was normal at 60.7±7.2%.

CONCLUSION: Exercise capacity is reduced and left ventricular ejection fraction is preserved in the long term after an arterial switch operation for transposition of the great arteries.

Original language	English
Pages (from-to)	895-902
Number of pages	8
Journal	Cardiology in the Young
Volume	28
Issue number	7
DOIs	https://doi.org/10.1017/S1047951117001032
Publication status	Published - Jul 2018

Keywords

LVEF
TGA
exercise capacity
transposition of the great arteries

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10.1017/S1047951117001032

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title = "Left ventricular function and exercise capacity after arterial switch operation for transposition of the great arteries: a systematic review and meta-analysis",

abstract = "BACKGROUND: The arterial switch operation for transposition of the great arteries was initially believed to be an anatomical correction. Recent evidence shows reduced exercise capacity and left ventricular function in varying degrees in the long term after an arterial switch operation.OBJECTIVE: To perform a meta-analysis on long-term exercise capacity and left ventricular ejection fraction after an arterial switch operation.METHODS: A literature search was performed to cover all studies on patients who had undergone a minimum of 6 years of follow-up that reported either left ventricular ejection fraction, peak oxygen uptake, peak workload, and/or peak heart rate. A meta-analysis was performed if more than three studies reported the outcome of interest.RESULTS: A total of 21 studies reported on the outcomes of interest. Oxygen uptake was consistently lower in patients who had undergone an arterial switch operation compared with healthy controls, with a pooled average peak oxygen uptake of 87.5±2.9% of predicted. The peak heart rate was also lower compared with that of controls, at 92±2% of predicted. Peak workload was significantly reduced in two studies. Pooled left ventricular ejection fraction was normal at 60.7±7.2%.CONCLUSION: Exercise capacity is reduced and left ventricular ejection fraction is preserved in the long term after an arterial switch operation for transposition of the great arteries.",

keywords = "LVEF, TGA, exercise capacity, transposition of the great arteries",

author = "{van Wijk}, {Sebastiaan W} and Driessen, {Mieke M} and Meijboom, {Folkert J} and Doevendans, {Pieter A} and Schoof, {Paul H} and Breur, {Hans M} and Tim Takken",

note = "Publisher Copyright: {\textcopyright} Cambridge University Press 2018.",

year = "2018",

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doi = "10.1017/S1047951117001032",

language = "English",

volume = "28",

pages = "895--902",

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Left ventricular function and exercise capacity after arterial switch operation for transposition of the great arteries: a systematic review and meta-analysis. / van Wijk, Sebastiaan W; Driessen, Mieke M; Meijboom, Folkert J et al.
In: Cardiology in the Young, Vol. 28, No. 7, 07.2018, p. 895-902.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Left ventricular function and exercise capacity after arterial switch operation for transposition of the great arteries

T2 - a systematic review and meta-analysis

AU - van Wijk, Sebastiaan W

AU - Driessen, Mieke M

AU - Meijboom, Folkert J

AU - Doevendans, Pieter A

AU - Schoof, Paul H

AU - Breur, Hans M

AU - Takken, Tim

PY - 2018/7

Y1 - 2018/7

N2 - BACKGROUND: The arterial switch operation for transposition of the great arteries was initially believed to be an anatomical correction. Recent evidence shows reduced exercise capacity and left ventricular function in varying degrees in the long term after an arterial switch operation.OBJECTIVE: To perform a meta-analysis on long-term exercise capacity and left ventricular ejection fraction after an arterial switch operation.METHODS: A literature search was performed to cover all studies on patients who had undergone a minimum of 6 years of follow-up that reported either left ventricular ejection fraction, peak oxygen uptake, peak workload, and/or peak heart rate. A meta-analysis was performed if more than three studies reported the outcome of interest.RESULTS: A total of 21 studies reported on the outcomes of interest. Oxygen uptake was consistently lower in patients who had undergone an arterial switch operation compared with healthy controls, with a pooled average peak oxygen uptake of 87.5±2.9% of predicted. The peak heart rate was also lower compared with that of controls, at 92±2% of predicted. Peak workload was significantly reduced in two studies. Pooled left ventricular ejection fraction was normal at 60.7±7.2%.CONCLUSION: Exercise capacity is reduced and left ventricular ejection fraction is preserved in the long term after an arterial switch operation for transposition of the great arteries.

AB - BACKGROUND: The arterial switch operation for transposition of the great arteries was initially believed to be an anatomical correction. Recent evidence shows reduced exercise capacity and left ventricular function in varying degrees in the long term after an arterial switch operation.OBJECTIVE: To perform a meta-analysis on long-term exercise capacity and left ventricular ejection fraction after an arterial switch operation.METHODS: A literature search was performed to cover all studies on patients who had undergone a minimum of 6 years of follow-up that reported either left ventricular ejection fraction, peak oxygen uptake, peak workload, and/or peak heart rate. A meta-analysis was performed if more than three studies reported the outcome of interest.RESULTS: A total of 21 studies reported on the outcomes of interest. Oxygen uptake was consistently lower in patients who had undergone an arterial switch operation compared with healthy controls, with a pooled average peak oxygen uptake of 87.5±2.9% of predicted. The peak heart rate was also lower compared with that of controls, at 92±2% of predicted. Peak workload was significantly reduced in two studies. Pooled left ventricular ejection fraction was normal at 60.7±7.2%.CONCLUSION: Exercise capacity is reduced and left ventricular ejection fraction is preserved in the long term after an arterial switch operation for transposition of the great arteries.

KW - LVEF

KW - TGA

KW - exercise capacity

KW - transposition of the great arteries

U2 - 10.1017/S1047951117001032

DO - 10.1017/S1047951117001032

M3 - Article

C2 - 29848397

SN - 1047-9511

VL - 28

SP - 895

EP - 902

JO - Cardiology in the Young

JF - Cardiology in the Young

IS - 7

ER -

Left ventricular function and exercise capacity after arterial switch operation for transposition of the great arteries: a systematic review and meta-analysis

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Keywords

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