Larger brains in medication naive high-functioning subjects with pervasive developmental disorder

Saskia J M C Palmen; Hilleke E Hulshoff Pol; Chantal Kemner; Hugo G Schnack; Joost Janssen; René S Kahn; Herman van Engeland

doi:10.1007/s10803-004-5282-2

Larger brains in medication naive high-functioning subjects with pervasive developmental disorder

Saskia J M C Palmen, Hilleke E Hulshoff Pol, Chantal Kemner, Hugo G Schnack, Joost Janssen, René S Kahn, Herman van Engeland

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Are brain volumes of individuals with Pervasive Developmental Disorder (PDD) still enlarged in adolescence and adulthood, and if so, is this enlargement confined to the gray and/or the white matter and is it global or more prominent in specific brain regions.

METHODS: Brain MRI scans were made of 21 adolescents with PDD and 21 closely matched controls.

RESULTS: All brain volumes, except the white matter, were significantly larger in patients. After correction for brain volume, ventricular volumes remained significantly larger in patients.

CONCLUSIONS: Patients showed a proportional, global increase in gray matter and cerebellum volume, and a disproportional increase in ventricular volumes. Thus, at least in high-functioning patients with PDD, brain enlargement may still be present in adult life.

Original language	English
Pages (from-to)	603-13
Number of pages	11
Journal	Journal of Autism and Developmental Disorders
Volume	34
Issue number	6
DOIs	https://doi.org/10.1007/s10803-004-5282-2
Publication status	Published - Dec 2004

Keywords

Adult
Brain
Cerebellum
Cerebral Cortex
Cerebral Ventricles
Child
Child Development Disorders, Pervasive
Cognition Disorders
Cross-Sectional Studies
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Magnetic Resonance Imaging
Male
Severity of Illness Index
Wechsler Scales
Journal Article
Research Support, Non-U.S. Gov't

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10.1007/s10803-004-5282-2

Cite this

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title = "Larger brains in medication naive high-functioning subjects with pervasive developmental disorder",

abstract = "BACKGROUND: Are brain volumes of individuals with Pervasive Developmental Disorder (PDD) still enlarged in adolescence and adulthood, and if so, is this enlargement confined to the gray and/or the white matter and is it global or more prominent in specific brain regions.METHODS: Brain MRI scans were made of 21 adolescents with PDD and 21 closely matched controls.RESULTS: All brain volumes, except the white matter, were significantly larger in patients. After correction for brain volume, ventricular volumes remained significantly larger in patients.CONCLUSIONS: Patients showed a proportional, global increase in gray matter and cerebellum volume, and a disproportional increase in ventricular volumes. Thus, at least in high-functioning patients with PDD, brain enlargement may still be present in adult life.",

keywords = "Adult, Brain, Cerebellum, Cerebral Cortex, Cerebral Ventricles, Child, Child Development Disorders, Pervasive, Cognition Disorders, Cross-Sectional Studies, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Severity of Illness Index, Wechsler Scales, Journal Article, Research Support, Non-U.S. Gov't",

author = "Palmen, {Saskia J M C} and {Hulshoff Pol}, {Hilleke E} and Chantal Kemner and Schnack, {Hugo G} and Joost Janssen and Kahn, {Ren{\'e} S} and {van Engeland}, Herman",

year = "2004",

month = dec,

doi = "10.1007/s10803-004-5282-2",

language = "English",

volume = "34",

pages = "603--13",

journal = "Journal of Autism and Developmental Disorders",

issn = "0162-3257",

publisher = "Springer New York",

number = "6",

}

TY - JOUR

T1 - Larger brains in medication naive high-functioning subjects with pervasive developmental disorder

AU - Palmen, Saskia J M C

AU - Hulshoff Pol, Hilleke E

AU - Kemner, Chantal

AU - Schnack, Hugo G

AU - Janssen, Joost

AU - Kahn, René S

AU - van Engeland, Herman

PY - 2004/12

Y1 - 2004/12

N2 - BACKGROUND: Are brain volumes of individuals with Pervasive Developmental Disorder (PDD) still enlarged in adolescence and adulthood, and if so, is this enlargement confined to the gray and/or the white matter and is it global or more prominent in specific brain regions.METHODS: Brain MRI scans were made of 21 adolescents with PDD and 21 closely matched controls.RESULTS: All brain volumes, except the white matter, were significantly larger in patients. After correction for brain volume, ventricular volumes remained significantly larger in patients.CONCLUSIONS: Patients showed a proportional, global increase in gray matter and cerebellum volume, and a disproportional increase in ventricular volumes. Thus, at least in high-functioning patients with PDD, brain enlargement may still be present in adult life.

AB - BACKGROUND: Are brain volumes of individuals with Pervasive Developmental Disorder (PDD) still enlarged in adolescence and adulthood, and if so, is this enlargement confined to the gray and/or the white matter and is it global or more prominent in specific brain regions.METHODS: Brain MRI scans were made of 21 adolescents with PDD and 21 closely matched controls.RESULTS: All brain volumes, except the white matter, were significantly larger in patients. After correction for brain volume, ventricular volumes remained significantly larger in patients.CONCLUSIONS: Patients showed a proportional, global increase in gray matter and cerebellum volume, and a disproportional increase in ventricular volumes. Thus, at least in high-functioning patients with PDD, brain enlargement may still be present in adult life.

KW - Adult

KW - Brain

KW - Cerebellum

KW - Cerebral Cortex

KW - Cerebral Ventricles

KW - Child

KW - Child Development Disorders, Pervasive

KW - Cognition Disorders

KW - Cross-Sectional Studies

KW - Diagnostic and Statistical Manual of Mental Disorders

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Severity of Illness Index

KW - Wechsler Scales

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1007/s10803-004-5282-2

DO - 10.1007/s10803-004-5282-2

M3 - Article

C2 - 15679181

SN - 0162-3257

VL - 34

SP - 603

EP - 613

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 6

ER -

Larger brains in medication naive high-functioning subjects with pervasive developmental disorder

Abstract

Keywords

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