LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes

Linde Meyaard; Gosse J. Adema; Chiwen Chang; Erica Woollatt; Grant R. Sutherland; Lewis L. Lanier; Joseph H. Phillips

doi:10.1016/S1074-7613(00)80530-0

LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes

Linde Meyaard, Gosse J. Adema, Chiwen Chang, Erica Woollatt, Grant R. Sutherland, Lewis L. Lanier, Joseph H. Phillips^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

235 Citations (Scopus)

Abstract

In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 is a 32 kDa transmembrane glyco-protein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-I and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell- mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.

Original language	English
Pages (from-to)	283-290
Number of pages	8
Journal	Immunity
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/S1074-7613(00)80530-0
Publication status	Published - 1 Jan 1997

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title = "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes",

abstract = "In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 is a 32 kDa transmembrane glyco-protein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-I and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell- mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.",

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T1 - LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes

AU - Meyaard, Linde

AU - Adema, Gosse J.

AU - Chang, Chiwen

AU - Woollatt, Erica

AU - Sutherland, Grant R.

AU - Lanier, Lewis L.

AU - Phillips, Joseph H.

PY - 1997/1/1

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N2 - In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 is a 32 kDa transmembrane glyco-protein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-I and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell- mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.

AB - In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 is a 32 kDa transmembrane glyco-protein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-I and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell- mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize human leukocyte antigen (HLA) class I molecules and thus represents a novel HLA class I-independent mechanism of NK cell regulation.

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LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes

Abstract

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