TY - JOUR
T1 - Lack of associations between serum leptin, a polymorphism in the gene for the β3-adrenergic receptor and glucose tolerance in the Dutch population
AU - Janssen, J. A.M.J.L.
AU - Koper, J. W.
AU - Stolk, R. P.
AU - Englaro, P.
AU - Uitterlinden, A. G.
AU - Huang, Q.
AU - Van Leeuwen, J. P.T.M.
AU - Blum, W. F.
AU - Attanasio, A. M.F.
AU - Pols, H. A.P.
AU - Grobbee, D. E.
AU - De Jong, F. H.
AU - Lamberts, S. W.J.
PY - 1998/8/24
Y1 - 1998/8/24
N2 - BACKGROUND: The associations between leptin levels and the prevalence of a polymorphism in the β3-adrenergic receptor were studied in a cross- sectional analysis of 600 participants in a population-based study, which were stratified for glucose tolerance by an oral glucose tolerance test. METHODS In a random sample of 600 participants in the Rotterdam study, aged 55-75 years at baseline (309 men, 291 women) the relationships were studied between the presence of Trp64 Arg mutation in the β3-adrenergic receptor gene and fasting leptin, glucose and insulin (fasting and after an oral glucose load), and other components of the insulin resistance syndrome. RESULTS: Mean age of the study population was 66.9 years (SD 5.7). Fasting serum leptin levels overall in men and women were 6.1 μg/l (SE 0.2) and 21.7 μg/l (0.9), respectively, (P<0.001). These differences were independent of age, body mass index and waist to hip ratio. We identified 73/600 persons who were heterozygotes for the Trp64 Arg polymorphism (allelic frequency 6.1%), but failed to find an association between the presence of this polymorphism and leptin or any measured parameter indicative for obesity, impaired glucose tolerance or type 2 diabetes mellitus. CONCLUSION: Heterozygosity for the Trp64Arg polymorphism of the β3-adrenergic receptor gene is not accompanied by obesity, impaired glucose tolerance and type 2 diabetes mellitus in the general elderly Dutch population, and is also not associated with changes in circulating leptin levels.
AB - BACKGROUND: The associations between leptin levels and the prevalence of a polymorphism in the β3-adrenergic receptor were studied in a cross- sectional analysis of 600 participants in a population-based study, which were stratified for glucose tolerance by an oral glucose tolerance test. METHODS In a random sample of 600 participants in the Rotterdam study, aged 55-75 years at baseline (309 men, 291 women) the relationships were studied between the presence of Trp64 Arg mutation in the β3-adrenergic receptor gene and fasting leptin, glucose and insulin (fasting and after an oral glucose load), and other components of the insulin resistance syndrome. RESULTS: Mean age of the study population was 66.9 years (SD 5.7). Fasting serum leptin levels overall in men and women were 6.1 μg/l (SE 0.2) and 21.7 μg/l (0.9), respectively, (P<0.001). These differences were independent of age, body mass index and waist to hip ratio. We identified 73/600 persons who were heterozygotes for the Trp64 Arg polymorphism (allelic frequency 6.1%), but failed to find an association between the presence of this polymorphism and leptin or any measured parameter indicative for obesity, impaired glucose tolerance or type 2 diabetes mellitus. CONCLUSION: Heterozygosity for the Trp64Arg polymorphism of the β3-adrenergic receptor gene is not accompanied by obesity, impaired glucose tolerance and type 2 diabetes mellitus in the general elderly Dutch population, and is also not associated with changes in circulating leptin levels.
UR - http://www.scopus.com/inward/record.url?scp=15444339759&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2265.1998.00513.x
DO - 10.1046/j.1365-2265.1998.00513.x
M3 - Article
C2 - 9828912
AN - SCOPUS:15444339759
SN - 0300-0664
VL - 49
SP - 229
EP - 234
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 2
ER -