Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study

Carolien Koop-Nieuwelink; Sanaz Sedaghat; Unal Mutlu; Silvan Licher; Oscar H Franco; M Arfan Ikram; Mirjam I Geerlings; M Kamran Ikram; Daniel Bos

doi:10.3233/JAD-181086

Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study

Carolien Koop-Nieuwelink, Sanaz Sedaghat, Unal Mutlu, Silvan Licher, Oscar H Franco, M Arfan Ikram, Mirjam I Geerlings, M Kamran Ikram, Daniel Bos

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.

Original language	English
Pages (from-to)	821-826
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	67
Issue number	3
Early online date	14 Jan 2019
DOIs	https://doi.org/10.3233/JAD-181086
Publication status	Published - 2019

Keywords

Dementia
epidemiology
glomerular filtration rate
kidney function
stroke

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title = "Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study",

abstract = "Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.",

keywords = "Dementia, epidemiology, glomerular filtration rate, kidney function, stroke",

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AU - Koop-Nieuwelink, Carolien

AU - Sedaghat, Sanaz

AU - Mutlu, Unal

AU - Licher, Silvan

AU - Franco, Oscar H

AU - Ikram, M Arfan

AU - Geerlings, Mirjam I

AU - Ikram, M Kamran

AU - Bos, Daniel

PY - 2019

Y1 - 2019

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AB - Longitudinal population-based data on effects of kidney dysfunction in the development of stroke and dementia remains inconclusive. We investigated associations of kidney function with risk of stroke and dementia in 5,993 community-dwelling individuals (mean age: 69.0 years, 57.2% women). We calculated estimated glomerular filtration rates based on creatinine, cystatin-C, and a combination of these two. During a mean follow-up of 11.6 years (69,790 person-years), 1,360 individuals suffered a stroke (n = 601) or developed dementia (n = 759). We found that an impaired kidney function was related to a higher risk of stroke, but not to dementia.

KW - Dementia

KW - epidemiology

KW - glomerular filtration rate

KW - kidney function

KW - stroke

U2 - 10.3233/JAD-181086

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C2 - 30664508

SN - 1387-2877

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EP - 826

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 3

ER -

Kidney Function and the Risk of Stroke and Dementia: The Rotterdam Study

Abstract

Keywords

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