KIAA1524: A novel MLL translocation partner in acute myeloid leukemia

Eva A. Coenen; C. Michel Zwaan; Claus Meyer; Rolf Marschalek; Rob Pieters; Lars T. van der Veken; H. Berna Beverloo; Marry M. Van den Heuvel-Eibrink

doi:10.1016/j.leukres.2010.08.017

KIAA1524: A novel MLL translocation partner in acute myeloid leukemia

Eva A. Coenen, C. Michel Zwaan, Claus Meyer, Rolf Marschalek, Rob Pieters, Lars T. van der Veken, H. Berna Beverloo, Marry M. Van den Heuvel-Eibrink^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

The Mixed Lineage Leukemia gene on chromosome 11q23 is a frequent site of recurrent translocations in acute leukemias. Its promiscuous character is reflected by the more than 60 different translocation partners described in literature. Prompted by karyotype and atypical FISH results, we identified a new translocation partner in infant acute myeloid leukemia, KIAA1524 on 3q13.13, also known as 'Cancerous Inhibitor of Protein phosphatase 2A (CIP2A)'. This gene was recently identified as a proto-oncogene stabilizing MYC protein in gastric carcinoma. KIAA1524 has never been related to hematologic malignancies before, and the current AML case is the first case in which an MLL-KIAA1524 fusion was described.

Original language	English
Pages (from-to)	133-135
Number of pages	3
Journal	Leukemia Research
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2010.08.017
Publication status	Published - 1 Jan 2011

Keywords

Acute myeloid leukemia
CIP2A
KIAA1524
MLL

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title = "KIAA1524: A novel MLL translocation partner in acute myeloid leukemia",

abstract = "The Mixed Lineage Leukemia gene on chromosome 11q23 is a frequent site of recurrent translocations in acute leukemias. Its promiscuous character is reflected by the more than 60 different translocation partners described in literature. Prompted by karyotype and atypical FISH results, we identified a new translocation partner in infant acute myeloid leukemia, KIAA1524 on 3q13.13, also known as 'Cancerous Inhibitor of Protein phosphatase 2A (CIP2A)'. This gene was recently identified as a proto-oncogene stabilizing MYC protein in gastric carcinoma. KIAA1524 has never been related to hematologic malignancies before, and the current AML case is the first case in which an MLL-KIAA1524 fusion was described.",

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AU - Coenen, Eva A.

AU - Zwaan, C. Michel

AU - Meyer, Claus

AU - Marschalek, Rolf

AU - Pieters, Rob

AU - van der Veken, Lars T.

AU - Beverloo, H. Berna

AU - Van den Heuvel-Eibrink, Marry M.

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AB - The Mixed Lineage Leukemia gene on chromosome 11q23 is a frequent site of recurrent translocations in acute leukemias. Its promiscuous character is reflected by the more than 60 different translocation partners described in literature. Prompted by karyotype and atypical FISH results, we identified a new translocation partner in infant acute myeloid leukemia, KIAA1524 on 3q13.13, also known as 'Cancerous Inhibitor of Protein phosphatase 2A (CIP2A)'. This gene was recently identified as a proto-oncogene stabilizing MYC protein in gastric carcinoma. KIAA1524 has never been related to hematologic malignancies before, and the current AML case is the first case in which an MLL-KIAA1524 fusion was described.

KW - Acute myeloid leukemia

KW - CIP2A

KW - KIAA1524

KW - MLL

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KIAA1524: A novel MLL translocation partner in acute myeloid leukemia

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Keywords

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