Joint surgery in von Willebrand disease: a multicentre cross-sectional study

K. P.M. van Galen; K. Meijer; H. C. Vogely; J. Eikenboom; R. E.G. Schutgens; M. H. Cnossen; K. Fijnvandraat; J. G. van der Bom; B. A.P. Laros-van Gorkom; F. W.G. Leebeek; E. P. Mauser-Bunschoten

doi:10.1111/hae.12834

Joint surgery in von Willebrand disease: a multicentre cross-sectional study

K. P.M. van Galen^*, K. Meijer, H. C. Vogely, J. Eikenboom, R. E.G. Schutgens, M. H. Cnossen, K. Fijnvandraat, J. G. van der Bom, B. A.P. Laros-van Gorkom, F. W.G. Leebeek, E. P. Mauser-Bunschoten,

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

BACKGROUND: Joint bleeds are reported by 23% of von Willebrand disease (VWD) patients and associated with orthopaedic surgery. Limited data are available on joint surgery in VWD.

AIM: To assess the prevalence, indications, management and complications of joint surgery in VWD patients.

METHODS: 804 VWD patients with historically lowest von Willebrand factor (VWF) activity ≤30 U dL(-1) completed a questionnaire on joint bleeds, joint damage and orthopaedic surgery. We retrieved additional medical file data of patients who underwent surgery on large joints (shoulder, elbow, hip, knee or ankle).

RESULTS: 116 out of 804 patients (14%) reported large joint surgery. Compared to VWD patients without previous orthopaedic surgery, these 116 patients reported more frequently a history of joint bleeds and joint damage (41% vs. 20%, P < 0.001 and 61% vs. 20%, P < 0.001). Medical file data on 126 large joint surgeries in 79 VWD patients revealed that this surgery was associated with joint damage due to prior joint bleeds in 24% of the procedures. Preoperative clotting factor correction (CFC) to prevent bleeding was administered in most cases (81%). Documentation on postoperative bleeding was found in 23 surgeries (18%).

CONCLUSIONS: Large joint surgery is reported by 14% of VWD patients, related to joint bleeds in 24% and seems associated with bleeding complications frequently despite perioperative CFC.

Original language	English
Pages (from-to)	256–262
Number of pages	7
Journal	Haemophilia
Volume	22
Issue number	2
DOIs	https://doi.org/10.1111/hae.12834
Publication status	Published - Mar 2016

Keywords

Arthropathy
Joint bleeds
Orthopaedic surgery
Von Willebrand disease

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10.1111/hae.12834

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@article{26e6f6882a4a4b299a47db61d6a1ef8e,

title = "Joint surgery in von Willebrand disease: a multicentre cross-sectional study",

abstract = "BACKGROUND: Joint bleeds are reported by 23% of von Willebrand disease (VWD) patients and associated with orthopaedic surgery. Limited data are available on joint surgery in VWD.AIM: To assess the prevalence, indications, management and complications of joint surgery in VWD patients.METHODS: 804 VWD patients with historically lowest von Willebrand factor (VWF) activity ≤30 U dL(-1) completed a questionnaire on joint bleeds, joint damage and orthopaedic surgery. We retrieved additional medical file data of patients who underwent surgery on large joints (shoulder, elbow, hip, knee or ankle).RESULTS: 116 out of 804 patients (14%) reported large joint surgery. Compared to VWD patients without previous orthopaedic surgery, these 116 patients reported more frequently a history of joint bleeds and joint damage (41% vs. 20%, P < 0.001 and 61% vs. 20%, P < 0.001). Medical file data on 126 large joint surgeries in 79 VWD patients revealed that this surgery was associated with joint damage due to prior joint bleeds in 24% of the procedures. Preoperative clotting factor correction (CFC) to prevent bleeding was administered in most cases (81%). Documentation on postoperative bleeding was found in 23 surgeries (18%).CONCLUSIONS: Large joint surgery is reported by 14% of VWD patients, related to joint bleeds in 24% and seems associated with bleeding complications frequently despite perioperative CFC.",

keywords = "Arthropathy, Joint bleeds, Orthopaedic surgery, Von Willebrand disease",

author = "{van Galen}, {K. P.M.} and K. Meijer and Vogely, {H. C.} and J. Eikenboom and Schutgens, {R. E.G.} and Cnossen, {M. H.} and K. Fijnvandraat and {van der Bom}, {J. G.} and {Laros-van Gorkom}, {B. A.P.} and Leebeek, {F. W.G.} and Mauser-Bunschoten, {E. P.}",

note = "{\textcopyright} 2015 John Wiley & Sons Ltd.",

year = "2016",

month = mar,

doi = "10.1111/hae.12834",

language = "English",

volume = "22",

pages = " 256–262",

journal = "Haemophilia",

issn = "1351-8216",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Joint surgery in von Willebrand disease

T2 - a multicentre cross-sectional study

AU - van Galen, K. P.M.

AU - Meijer, K.

AU - Vogely, H. C.

AU - Eikenboom, J.

AU - Schutgens, R. E.G.

AU - Cnossen, M. H.

AU - Fijnvandraat, K.

AU - van der Bom, J. G.

AU - Laros-van Gorkom, B. A.P.

AU - Leebeek, F. W.G.

AU - Mauser-Bunschoten, E. P.

PY - 2016/3

Y1 - 2016/3

N2 - BACKGROUND: Joint bleeds are reported by 23% of von Willebrand disease (VWD) patients and associated with orthopaedic surgery. Limited data are available on joint surgery in VWD.AIM: To assess the prevalence, indications, management and complications of joint surgery in VWD patients.METHODS: 804 VWD patients with historically lowest von Willebrand factor (VWF) activity ≤30 U dL(-1) completed a questionnaire on joint bleeds, joint damage and orthopaedic surgery. We retrieved additional medical file data of patients who underwent surgery on large joints (shoulder, elbow, hip, knee or ankle).RESULTS: 116 out of 804 patients (14%) reported large joint surgery. Compared to VWD patients without previous orthopaedic surgery, these 116 patients reported more frequently a history of joint bleeds and joint damage (41% vs. 20%, P < 0.001 and 61% vs. 20%, P < 0.001). Medical file data on 126 large joint surgeries in 79 VWD patients revealed that this surgery was associated with joint damage due to prior joint bleeds in 24% of the procedures. Preoperative clotting factor correction (CFC) to prevent bleeding was administered in most cases (81%). Documentation on postoperative bleeding was found in 23 surgeries (18%).CONCLUSIONS: Large joint surgery is reported by 14% of VWD patients, related to joint bleeds in 24% and seems associated with bleeding complications frequently despite perioperative CFC.

AB - BACKGROUND: Joint bleeds are reported by 23% of von Willebrand disease (VWD) patients and associated with orthopaedic surgery. Limited data are available on joint surgery in VWD.AIM: To assess the prevalence, indications, management and complications of joint surgery in VWD patients.METHODS: 804 VWD patients with historically lowest von Willebrand factor (VWF) activity ≤30 U dL(-1) completed a questionnaire on joint bleeds, joint damage and orthopaedic surgery. We retrieved additional medical file data of patients who underwent surgery on large joints (shoulder, elbow, hip, knee or ankle).RESULTS: 116 out of 804 patients (14%) reported large joint surgery. Compared to VWD patients without previous orthopaedic surgery, these 116 patients reported more frequently a history of joint bleeds and joint damage (41% vs. 20%, P < 0.001 and 61% vs. 20%, P < 0.001). Medical file data on 126 large joint surgeries in 79 VWD patients revealed that this surgery was associated with joint damage due to prior joint bleeds in 24% of the procedures. Preoperative clotting factor correction (CFC) to prevent bleeding was administered in most cases (81%). Documentation on postoperative bleeding was found in 23 surgeries (18%).CONCLUSIONS: Large joint surgery is reported by 14% of VWD patients, related to joint bleeds in 24% and seems associated with bleeding complications frequently despite perioperative CFC.

KW - Arthropathy

KW - Joint bleeds

KW - Orthopaedic surgery

KW - Von Willebrand disease

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U2 - 10.1111/hae.12834

DO - 10.1111/hae.12834

M3 - Article

C2 - 26551280

SN - 1351-8216

VL - 22

SP - 256

EP - 262

JO - Haemophilia

JF - Haemophilia

IS - 2

ER -

Joint surgery in von Willebrand disease: a multicentre cross-sectional study

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