Is blood pressure increased 19 years after intrauterine growth restriction and preterm birth? A prospective follow-up study in the Netherlands

MG Keijzer-Veen; MJJ Finken; J Nauta; FW Dekker; ETM Hille; M Frolich; JM Wit; AJ van der Heijden

doi:10.1542/peds.2005-0309

Is blood pressure increased 19 years after intrauterine growth restriction and preterm birth? A prospective follow-up study in the Netherlands

MG Keijzer-Veen, MJJ Finken, J Nauta, FW Dekker, ETM Hille, M Frolich, JM Wit, AJ van der Heijden^*,

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective. To determine whether intrauterine growth restriction ( IUGR) is a predisposing factor for high blood pressure ( BP) in 19-year-olds who were born ( very) preterm.

Methods. A prospective follow-up study was conducted at age 19 in individuals who born preterm in the Netherlands in 1983. Systolic, diastolic, and mean BP values and plasma renin activity concentration were obtained in 422 young adults who were born with a gestational age (GA) <32 weeks. BP values were also measured in 174 individuals who born with a GA of >= 32 weeks and a birth weight of <1500 g.

Results. An increased prevalence of hypertension and probably also of prehypertensive stage was found. IUGR, birth weight, GA, and plasma renin activity were not associated with BP. Current weight and BMI were the best predicting factors for systolic BP at the age of 19 years.

Conclusions. The prevalence of hypertension is high in individuals who were born preterm when compared with the general population. In the individuals who were born very preterm, no support to the hypothesis that low birth weight is associated with increased BP at young adult age can be given.

Original language	English
Pages (from-to)	725-731
Number of pages	7
Journal	Pediatrics
Volume	116
Issue number	3
DOIs	https://doi.org/10.1542/peds.2005-0309
Publication status	Published - Sept 2005
Externally published	Yes

Keywords

adulthood
blood pressure
follow-up studies
intrauterine growth retardation
preterm infants
FETAL ORIGINS HYPOTHESIS
JOINT NATIONAL COMMITTEE
FOR-GESTATIONAL-AGE
INSULIN SENSITIVITY
YOUNG-ADULTS
WEIGHT
HYPERTENSION
LIFE
INFANTS
DISEASE

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10.1542/peds.2005-0309

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title = "Is blood pressure increased 19 years after intrauterine growth restriction and preterm birth? A prospective follow-up study in the Netherlands",

abstract = "Objective. To determine whether intrauterine growth restriction ( IUGR) is a predisposing factor for high blood pressure ( BP) in 19-year-olds who were born ( very) preterm.Methods. A prospective follow-up study was conducted at age 19 in individuals who born preterm in the Netherlands in 1983. Systolic, diastolic, and mean BP values and plasma renin activity concentration were obtained in 422 young adults who were born with a gestational age (GA) <32 weeks. BP values were also measured in 174 individuals who born with a GA of >= 32 weeks and a birth weight of <1500 g.Results. An increased prevalence of hypertension and probably also of prehypertensive stage was found. IUGR, birth weight, GA, and plasma renin activity were not associated with BP. Current weight and BMI were the best predicting factors for systolic BP at the age of 19 years.Conclusions. The prevalence of hypertension is high in individuals who were born preterm when compared with the general population. In the individuals who were born very preterm, no support to the hypothesis that low birth weight is associated with increased BP at young adult age can be given.",

keywords = "adulthood, blood pressure, follow-up studies, intrauterine growth retardation, preterm infants, FETAL ORIGINS HYPOTHESIS, JOINT NATIONAL COMMITTEE, FOR-GESTATIONAL-AGE, INSULIN SENSITIVITY, YOUNG-ADULTS, WEIGHT, HYPERTENSION, LIFE, INFANTS, DISEASE",

author = "MG Keijzer-Veen and MJJ Finken and J Nauta and FW Dekker and ETM Hille and M Frolich and JM Wit and {van der Heijden}, AJ",

year = "2005",

month = sep,

doi = "10.1542/peds.2005-0309",

language = "English",

volume = "116",

pages = "725--731",

journal = "Pediatrics",

issn = "0031-4005",

publisher = "American Academy of Pediatrics",

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T1 - Is blood pressure increased 19 years after intrauterine growth restriction and preterm birth? A prospective follow-up study in the Netherlands

AU - Keijzer-Veen, MG

AU - Finken, MJJ

AU - Nauta, J

AU - Dekker, FW

AU - Hille, ETM

AU - Frolich, M

AU - Wit, JM

AU - van der Heijden, AJ

PY - 2005/9

Y1 - 2005/9

N2 - Objective. To determine whether intrauterine growth restriction ( IUGR) is a predisposing factor for high blood pressure ( BP) in 19-year-olds who were born ( very) preterm.Methods. A prospective follow-up study was conducted at age 19 in individuals who born preterm in the Netherlands in 1983. Systolic, diastolic, and mean BP values and plasma renin activity concentration were obtained in 422 young adults who were born with a gestational age (GA) <32 weeks. BP values were also measured in 174 individuals who born with a GA of >= 32 weeks and a birth weight of <1500 g.Results. An increased prevalence of hypertension and probably also of prehypertensive stage was found. IUGR, birth weight, GA, and plasma renin activity were not associated with BP. Current weight and BMI were the best predicting factors for systolic BP at the age of 19 years.Conclusions. The prevalence of hypertension is high in individuals who were born preterm when compared with the general population. In the individuals who were born very preterm, no support to the hypothesis that low birth weight is associated with increased BP at young adult age can be given.

AB - Objective. To determine whether intrauterine growth restriction ( IUGR) is a predisposing factor for high blood pressure ( BP) in 19-year-olds who were born ( very) preterm.Methods. A prospective follow-up study was conducted at age 19 in individuals who born preterm in the Netherlands in 1983. Systolic, diastolic, and mean BP values and plasma renin activity concentration were obtained in 422 young adults who were born with a gestational age (GA) <32 weeks. BP values were also measured in 174 individuals who born with a GA of >= 32 weeks and a birth weight of <1500 g.Results. An increased prevalence of hypertension and probably also of prehypertensive stage was found. IUGR, birth weight, GA, and plasma renin activity were not associated with BP. Current weight and BMI were the best predicting factors for systolic BP at the age of 19 years.Conclusions. The prevalence of hypertension is high in individuals who were born preterm when compared with the general population. In the individuals who were born very preterm, no support to the hypothesis that low birth weight is associated with increased BP at young adult age can be given.

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KW - blood pressure

KW - follow-up studies

KW - intrauterine growth retardation

KW - preterm infants

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KW - JOINT NATIONAL COMMITTEE

KW - FOR-GESTATIONAL-AGE

KW - INSULIN SENSITIVITY

KW - YOUNG-ADULTS

KW - WEIGHT

KW - HYPERTENSION

KW - LIFE

KW - INFANTS

KW - DISEASE

U2 - 10.1542/peds.2005-0309

DO - 10.1542/peds.2005-0309

M3 - Article

C2 - 16140714

SN - 0031-4005

VL - 116

SP - 725

EP - 731

JO - Pediatrics

JF - Pediatrics

IS - 3

ER -

Is blood pressure increased 19 years after intrauterine growth restriction and preterm birth? A prospective follow-up study in the Netherlands

Abstract

Keywords

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