TY - JOUR
T1 - Iron status and its association with HbA1c levels in Dutch children with diabetes mellitus type 1
AU - Akkermans, Marjolijn D.
AU - Houdijk, E. C.A.Mieke
AU - Bakker, Boudewijn
AU - Clement-De Boers, Agnes
AU - Van Der Kaay, Daniëlle C.M.
AU - De Vries, Martine C.
AU - Woltering, M. Claire
AU - Mul, Dick
AU - Van Goudoever, Johannes B.
AU - Brus, Frank
N1 - Publisher Copyright:
© Springer-Verlag GmbH Germany, part of Springer Nature 2018.
PY - 2018/4
Y1 - 2018/4
N2 - Children with diabetes mellitus (DM) type 1 may be at risk for iron deficiency (ID) although this has been little studied. ID is either an absolute (depleted iron stores) or a functional (restricted iron stores due to chronic inflammation) deficiency each requiring a different therapeutic approach. Unfortunately, absolute ID is often not distinguished from functional ID. Furthermore, iron-deficient anemia may influence hemoglobin A1c (HbA1c) levels.We aimed to determine the prevalence and type of ID and investigate its association with HbA1c levels in pediatric DM type 1 patients. We performed a two-center prospective observational study in which the iron status of Dutch children with DM type 1 was determined during a regular check-up. Absolute ID and functional ID were found in 13/227 (5.7%) and 100/214 (47%) patients, respectively, while only 15/113 (13%) patients also had anemia. HbA1c levels in patients with and without a deprived iron status (absolute or functional) were not significantly different (65 ± 17 vs. 65 ± 16 mmol/mol, p = 0.815). Conclusion: Functional, but not absolute, ID was common in Dutch pediatric DM type 1 patients. HbA1c levels were not associated with ID, which can be explained by the relatively mild deprived iron status in our patients. Trial registration: NTR4642.
AB - Children with diabetes mellitus (DM) type 1 may be at risk for iron deficiency (ID) although this has been little studied. ID is either an absolute (depleted iron stores) or a functional (restricted iron stores due to chronic inflammation) deficiency each requiring a different therapeutic approach. Unfortunately, absolute ID is often not distinguished from functional ID. Furthermore, iron-deficient anemia may influence hemoglobin A1c (HbA1c) levels.We aimed to determine the prevalence and type of ID and investigate its association with HbA1c levels in pediatric DM type 1 patients. We performed a two-center prospective observational study in which the iron status of Dutch children with DM type 1 was determined during a regular check-up. Absolute ID and functional ID were found in 13/227 (5.7%) and 100/214 (47%) patients, respectively, while only 15/113 (13%) patients also had anemia. HbA1c levels in patients with and without a deprived iron status (absolute or functional) were not significantly different (65 ± 17 vs. 65 ± 16 mmol/mol, p = 0.815). Conclusion: Functional, but not absolute, ID was common in Dutch pediatric DM type 1 patients. HbA1c levels were not associated with ID, which can be explained by the relatively mild deprived iron status in our patients. Trial registration: NTR4642.
KW - Anemia
KW - Diabetes mellitus type 1
KW - Hemoglobin A1c protein
KW - Iron deficiency
UR - http://www.scopus.com/inward/record.url?scp=85045050870&partnerID=8YFLogxK
U2 - 10.1007/s00431-018-3104-3
DO - 10.1007/s00431-018-3104-3
M3 - Article
C2 - 29396628
AN - SCOPUS:85045050870
SN - 0340-6199
VL - 177
SP - 603
EP - 610
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 4
ER -