Iron Deficiency, Anemia and Mortality in Renal Transplant Recipients

Michele F. Eisenga; Isidor Minovic; Stefan P Berger; Jenny E. Kootstra-Ros; Else van den Berg; Ineke J. Riphagen; Gerjan J. Navis; Peter Van der Meer; Stephan J. L. Bakker; Carlo A. J. M. Gaillard

doi:10.1111/tri.12821

Iron Deficiency, Anemia and Mortality in Renal Transplant Recipients

Michele F. Eisenga, Isidor Minovic, Stefan P Berger, Jenny E. Kootstra-Ros, Else van den Berg, Ineke J. Riphagen, Gerjan J. Navis, Peter Van der Meer, Stephan J. L. Bakker, Carlo A. J. M. Gaillard

Divison of Internal Medicine and Dermatology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Anemia, iron deficiency anemia (IDA), and iron deficiency (ID) are highly prevalent in renal transplant recipients (RTR). Anemia is associated with poor outcome, but the role of ID is unknown. Therefore, we aimed to investigate the association of ID, irrespective of anemia, with all-cause mortality in RTR. Cox regression analyses were used to investigate prospective associations. In 700 RTR, prevalences of anemia, IDA, and ID were 34%, 13%, and 30%, respectively. During follow-up for 3.1 (2.7-3.9) years, 81 (12%) RTR died. In univariable analysis, anemia [HR, 1.72 (95% CI: 1.11-2.66), P = 0.02], IDA [2.44 (1.48-4.01), P

Original language	English
Pages (from-to)	1176-1183
Number of pages	8
Journal	Transplant International
Volume	29
Issue number	11
DOIs	https://doi.org/10.1111/tri.12821
Publication status	Published - Nov 2016

Keywords

anemia
iron deficiency
kidney transplantation
mortality
CORONARY-HEART-DISEASE
C-REACTIVE PROTEIN
POSTTRANSPLANTATION ANEMIA
KIDNEY
INFLAMMATION
MANAGEMENT
FAILURE
RISK
METABOLISM
RATIONALE

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title = "Iron Deficiency, Anemia and Mortality in Renal Transplant Recipients",

abstract = "Anemia, iron deficiency anemia (IDA), and iron deficiency (ID) are highly prevalent in renal transplant recipients (RTR). Anemia is associated with poor outcome, but the role of ID is unknown. Therefore, we aimed to investigate the association of ID, irrespective of anemia, with all-cause mortality in RTR. Cox regression analyses were used to investigate prospective associations. In 700 RTR, prevalences of anemia, IDA, and ID were 34%, 13%, and 30%, respectively. During follow-up for 3.1 (2.7-3.9) years, 81 (12%) RTR died. In univariable analysis, anemia [HR, 1.72 (95% CI: 1.11-2.66), P = 0.02], IDA [2.44 (1.48-4.01), P ",

keywords = "anemia, iron deficiency, kidney transplantation, mortality, CORONARY-HEART-DISEASE, C-REACTIVE PROTEIN, POSTTRANSPLANTATION ANEMIA, KIDNEY, INFLAMMATION, MANAGEMENT, FAILURE, RISK, METABOLISM, RATIONALE",

author = "Eisenga, {Michele F.} and Isidor Minovic and Berger, {Stefan P} and Kootstra-Ros, {Jenny E.} and {van den Berg}, Else and Riphagen, {Ineke J.} and Navis, {Gerjan J.} and {Van der Meer}, Peter and Bakker, {Stephan J. L.} and Gaillard, {Carlo A. J. M.}",

year = "2016",

month = nov,

doi = "10.1111/tri.12821",

language = "English",

volume = "29",

pages = "1176--1183",

journal = "Transplant International",

issn = "0934-0874",

publisher = "Wiley-Blackwell",

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T1 - Iron Deficiency, Anemia and Mortality in Renal Transplant Recipients

AU - Eisenga, Michele F.

AU - Minovic, Isidor

AU - Berger, Stefan P

AU - Kootstra-Ros, Jenny E.

AU - van den Berg, Else

AU - Riphagen, Ineke J.

AU - Navis, Gerjan J.

AU - Van der Meer, Peter

AU - Bakker, Stephan J. L.

AU - Gaillard, Carlo A. J. M.

PY - 2016/11

Y1 - 2016/11

N2 - Anemia, iron deficiency anemia (IDA), and iron deficiency (ID) are highly prevalent in renal transplant recipients (RTR). Anemia is associated with poor outcome, but the role of ID is unknown. Therefore, we aimed to investigate the association of ID, irrespective of anemia, with all-cause mortality in RTR. Cox regression analyses were used to investigate prospective associations. In 700 RTR, prevalences of anemia, IDA, and ID were 34%, 13%, and 30%, respectively. During follow-up for 3.1 (2.7-3.9) years, 81 (12%) RTR died. In univariable analysis, anemia [HR, 1.72 (95% CI: 1.11-2.66), P = 0.02], IDA [2.44 (1.48-4.01), P

AB - Anemia, iron deficiency anemia (IDA), and iron deficiency (ID) are highly prevalent in renal transplant recipients (RTR). Anemia is associated with poor outcome, but the role of ID is unknown. Therefore, we aimed to investigate the association of ID, irrespective of anemia, with all-cause mortality in RTR. Cox regression analyses were used to investigate prospective associations. In 700 RTR, prevalences of anemia, IDA, and ID were 34%, 13%, and 30%, respectively. During follow-up for 3.1 (2.7-3.9) years, 81 (12%) RTR died. In univariable analysis, anemia [HR, 1.72 (95% CI: 1.11-2.66), P = 0.02], IDA [2.44 (1.48-4.01), P

KW - anemia

KW - iron deficiency

KW - kidney transplantation

KW - mortality

KW - CORONARY-HEART-DISEASE

KW - C-REACTIVE PROTEIN

KW - POSTTRANSPLANTATION ANEMIA

KW - KIDNEY

KW - INFLAMMATION

KW - MANAGEMENT

KW - FAILURE

KW - RISK

KW - METABOLISM

KW - RATIONALE

U2 - 10.1111/tri.12821

DO - 10.1111/tri.12821

M3 - Article

SN - 0934-0874

VL - 29

SP - 1176

EP - 1183

JO - Transplant International

JF - Transplant International

IS - 11

ER -

Iron Deficiency, Anemia and Mortality in Renal Transplant Recipients

Abstract

Keywords

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