In vivo coronary lesion differentiation with computed tomography angiography and intravascular ultrasound as compared to optical coherence tomography

Wouter G Wieringa; Chris P H Lexis; Erik Lipsic; Hindrik W van der Werf; Johannes G M Burgerhof; Vincent E Hagens; G Louis Bartels; Alexander Broersen; Remco A Schurer; Eng-Shiong Tan; Pim van der Harst; Ad F M van den Heuvel; Tineke P Willems; Gabija Pundziute

doi:10.1016/j.jcct.2017.01.004

In vivo coronary lesion differentiation with computed tomography angiography and intravascular ultrasound as compared to optical coherence tomography

Wouter G Wieringa, Chris P H Lexis, Erik Lipsic, Hindrik W van der Werf, Johannes G M Burgerhof, Vincent E Hagens, G Louis Bartels, Alexander Broersen, Remco A Schurer, Eng-Shiong Tan, Pim van der Harst, Ad F M van den Heuvel, Tineke P Willems, Gabija Pundziute

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: In vitro studies have shown the feasibility of coronary lesion grading with computed tomography angiography (CTA), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) as compared to histology, whereas OCT had the highest discriminatory capacity.

OBJECTIVE: We investigated the ability of CTA and IVUS to differentiate between early and advanced coronary lesions in vivo, OCT serving as standard of reference.

METHODS: Multimodality imaging was prospectively performed in 30 NSTEMI patients. Plaque characteristics were assessed in 1083 cross-sections of 30 culprit lesions, co-registered among modalities. Absence of plaque, fibrous and fibrocalcific plaque on OCT were defined as early plaque, whereas lipid rich-plaque on OCT was defined as advanced plaque. Odds ratios adjusted for clustering were calculated to assess associations between plaque types on CTA and IVUS with early or advanced plaque.

RESULTS: Normal findings on CTA as well as on IVUS were associated with early plaque. Non-calcified, calcified plaques and the napkin ring sign on CTA were associated with advanced plaque. On IVUS, fatty and calcified plaques were associated with advanced plaque.

CONCLUSIONS: In vivo coronary plaque characteristics on CTA and IVUS are associated with plaque characteristics on OCT. Of note, normal findings on CTA and IVUS relate to early lesions on OCT. Nevertheless, multiple plaque features on CTA and IVUS are related to advanced plaques on OCT, which may make it difficult to use qualitative plaque assessment in clinical practice.

Original language	English
Pages (from-to)	111-118
Number of pages	8
Journal	Journal of cardiovascular computed tomography
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.jcct.2017.01.004
Publication status	Published - 1 Mar 2017
Externally published	Yes

Keywords

Aged
Chi-Square Distribution
Computed Tomography Angiography
Coronary Angiography/methods
Coronary Artery Disease/diagnostic imaging
Coronary Vessels/diagnostic imaging
Diagnosis, Differential
Disease Progression
Feasibility Studies
Female
Fibrosis
Humans
Logistic Models
Male
Middle Aged
Multidetector Computed Tomography
Multimodal Imaging/methods
Non-ST Elevated Myocardial Infarction/diagnostic imaging
Observer Variation
Odds Ratio
Plaque, Atherosclerotic
Predictive Value of Tests
Prospective Studies
Reproducibility of Results
Tomography, Optical Coherence
Ultrasonography, Interventional
Vascular Calcification/diagnostic imaging
Optical coherence tomography
Computed tomography
Coronary atherosclerosis
Intravascular ultrasound

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10.1016/j.jcct.2017.01.004

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Wieringa, W. G., Lexis, C. P. H., Lipsic, E., van der Werf, H. W., Burgerhof, J. G. M., Hagens, V. E., Bartels, G. L., Broersen, A., Schurer, R. A., Tan, E.-S., van der Harst, P., van den Heuvel, A. F. M., Willems, T. P., & Pundziute, G. (2017). In vivo coronary lesion differentiation with computed tomography angiography and intravascular ultrasound as compared to optical coherence tomography. Journal of cardiovascular computed tomography, 11(2), 111-118. https://doi.org/10.1016/j.jcct.2017.01.004

@article{e6e95299cdbd432296457d8c961b7049,

title = "In vivo coronary lesion differentiation with computed tomography angiography and intravascular ultrasound as compared to optical coherence tomography",

abstract = "BACKGROUND: In vitro studies have shown the feasibility of coronary lesion grading with computed tomography angiography (CTA), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) as compared to histology, whereas OCT had the highest discriminatory capacity.OBJECTIVE: We investigated the ability of CTA and IVUS to differentiate between early and advanced coronary lesions in vivo, OCT serving as standard of reference.METHODS: Multimodality imaging was prospectively performed in 30 NSTEMI patients. Plaque characteristics were assessed in 1083 cross-sections of 30 culprit lesions, co-registered among modalities. Absence of plaque, fibrous and fibrocalcific plaque on OCT were defined as early plaque, whereas lipid rich-plaque on OCT was defined as advanced plaque. Odds ratios adjusted for clustering were calculated to assess associations between plaque types on CTA and IVUS with early or advanced plaque.RESULTS: Normal findings on CTA as well as on IVUS were associated with early plaque. Non-calcified, calcified plaques and the napkin ring sign on CTA were associated with advanced plaque. On IVUS, fatty and calcified plaques were associated with advanced plaque.CONCLUSIONS: In vivo coronary plaque characteristics on CTA and IVUS are associated with plaque characteristics on OCT. Of note, normal findings on CTA and IVUS relate to early lesions on OCT. Nevertheless, multiple plaque features on CTA and IVUS are related to advanced plaques on OCT, which may make it difficult to use qualitative plaque assessment in clinical practice.",

keywords = "Aged, Chi-Square Distribution, Computed Tomography Angiography, Coronary Angiography/methods, Coronary Artery Disease/diagnostic imaging, Coronary Vessels/diagnostic imaging, Diagnosis, Differential, Disease Progression, Feasibility Studies, Female, Fibrosis, Humans, Logistic Models, Male, Middle Aged, Multidetector Computed Tomography, Multimodal Imaging/methods, Non-ST Elevated Myocardial Infarction/diagnostic imaging, Observer Variation, Odds Ratio, Plaque, Atherosclerotic, Predictive Value of Tests, Prospective Studies, Reproducibility of Results, Tomography, Optical Coherence, Ultrasonography, Interventional, Vascular Calcification/diagnostic imaging, Optical coherence tomography, Computed tomography, Coronary atherosclerosis, Intravascular ultrasound",

author = "Wieringa, {Wouter G} and Lexis, {Chris P H} and Erik Lipsic and {van der Werf}, {Hindrik W} and Burgerhof, {Johannes G M} and Hagens, {Vincent E} and Bartels, {G Louis} and Alexander Broersen and Schurer, {Remco A} and Eng-Shiong Tan and {van der Harst}, Pim and {van den Heuvel}, {Ad F M} and Willems, {Tineke P} and Gabija Pundziute",

note = "Publisher Copyright: {\textcopyright} 2017 Society of Cardiovascular Computed Tomography",

year = "2017",

month = mar,

day = "1",

doi = "10.1016/j.jcct.2017.01.004",

language = "English",

volume = "11",

pages = "111--118",

journal = "Journal of cardiovascular computed tomography",

issn = "1876-861X",

publisher = "Elsevier",

number = "2",

}

Wieringa, WG, Lexis, CPH, Lipsic, E, van der Werf, HW, Burgerhof, JGM, Hagens, VE, Bartels, GL, Broersen, A, Schurer, RA, Tan, E-S, van der Harst, P, van den Heuvel, AFM, Willems, TP & Pundziute, G 2017, 'In vivo coronary lesion differentiation with computed tomography angiography and intravascular ultrasound as compared to optical coherence tomography', Journal of cardiovascular computed tomography, vol. 11, no. 2, pp. 111-118. https://doi.org/10.1016/j.jcct.2017.01.004

In vivo coronary lesion differentiation with computed tomography angiography and intravascular ultrasound as compared to optical coherence tomography. / Wieringa, Wouter G; Lexis, Chris P H; Lipsic, Erik et al.
In: Journal of cardiovascular computed tomography, Vol. 11, No. 2, 01.03.2017, p. 111-118.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - In vivo coronary lesion differentiation with computed tomography angiography and intravascular ultrasound as compared to optical coherence tomography

AU - Wieringa, Wouter G

AU - Lexis, Chris P H

AU - Lipsic, Erik

AU - van der Werf, Hindrik W

AU - Burgerhof, Johannes G M

AU - Hagens, Vincent E

AU - Bartels, G Louis

AU - Broersen, Alexander

AU - Schurer, Remco A

AU - Tan, Eng-Shiong

AU - van der Harst, Pim

AU - van den Heuvel, Ad F M

AU - Willems, Tineke P

AU - Pundziute, Gabija

PY - 2017/3/1

Y1 - 2017/3/1

N2 - BACKGROUND: In vitro studies have shown the feasibility of coronary lesion grading with computed tomography angiography (CTA), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) as compared to histology, whereas OCT had the highest discriminatory capacity.OBJECTIVE: We investigated the ability of CTA and IVUS to differentiate between early and advanced coronary lesions in vivo, OCT serving as standard of reference.METHODS: Multimodality imaging was prospectively performed in 30 NSTEMI patients. Plaque characteristics were assessed in 1083 cross-sections of 30 culprit lesions, co-registered among modalities. Absence of plaque, fibrous and fibrocalcific plaque on OCT were defined as early plaque, whereas lipid rich-plaque on OCT was defined as advanced plaque. Odds ratios adjusted for clustering were calculated to assess associations between plaque types on CTA and IVUS with early or advanced plaque.RESULTS: Normal findings on CTA as well as on IVUS were associated with early plaque. Non-calcified, calcified plaques and the napkin ring sign on CTA were associated with advanced plaque. On IVUS, fatty and calcified plaques were associated with advanced plaque.CONCLUSIONS: In vivo coronary plaque characteristics on CTA and IVUS are associated with plaque characteristics on OCT. Of note, normal findings on CTA and IVUS relate to early lesions on OCT. Nevertheless, multiple plaque features on CTA and IVUS are related to advanced plaques on OCT, which may make it difficult to use qualitative plaque assessment in clinical practice.

AB - BACKGROUND: In vitro studies have shown the feasibility of coronary lesion grading with computed tomography angiography (CTA), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) as compared to histology, whereas OCT had the highest discriminatory capacity.OBJECTIVE: We investigated the ability of CTA and IVUS to differentiate between early and advanced coronary lesions in vivo, OCT serving as standard of reference.METHODS: Multimodality imaging was prospectively performed in 30 NSTEMI patients. Plaque characteristics were assessed in 1083 cross-sections of 30 culprit lesions, co-registered among modalities. Absence of plaque, fibrous and fibrocalcific plaque on OCT were defined as early plaque, whereas lipid rich-plaque on OCT was defined as advanced plaque. Odds ratios adjusted for clustering were calculated to assess associations between plaque types on CTA and IVUS with early or advanced plaque.RESULTS: Normal findings on CTA as well as on IVUS were associated with early plaque. Non-calcified, calcified plaques and the napkin ring sign on CTA were associated with advanced plaque. On IVUS, fatty and calcified plaques were associated with advanced plaque.CONCLUSIONS: In vivo coronary plaque characteristics on CTA and IVUS are associated with plaque characteristics on OCT. Of note, normal findings on CTA and IVUS relate to early lesions on OCT. Nevertheless, multiple plaque features on CTA and IVUS are related to advanced plaques on OCT, which may make it difficult to use qualitative plaque assessment in clinical practice.

KW - Aged

KW - Chi-Square Distribution

KW - Computed Tomography Angiography

KW - Coronary Angiography/methods

KW - Coronary Artery Disease/diagnostic imaging

KW - Coronary Vessels/diagnostic imaging

KW - Diagnosis, Differential

KW - Disease Progression

KW - Feasibility Studies

KW - Female

KW - Fibrosis

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Multidetector Computed Tomography

KW - Multimodal Imaging/methods

KW - Non-ST Elevated Myocardial Infarction/diagnostic imaging

KW - Observer Variation

KW - Odds Ratio

KW - Plaque, Atherosclerotic

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Reproducibility of Results

KW - Tomography, Optical Coherence

KW - Ultrasonography, Interventional

KW - Vascular Calcification/diagnostic imaging

KW - Optical coherence tomography

KW - Computed tomography

KW - Coronary atherosclerosis

KW - Intravascular ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85011317266&partnerID=8YFLogxK

U2 - 10.1016/j.jcct.2017.01.004

DO - 10.1016/j.jcct.2017.01.004

M3 - Article

C2 - 28169175

SN - 1876-861X

VL - 11

SP - 111

EP - 118

JO - Journal of cardiovascular computed tomography

JF - Journal of cardiovascular computed tomography

IS - 2

ER -

In vivo coronary lesion differentiation with computed tomography angiography and intravascular ultrasound as compared to optical coherence tomography

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Keywords

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