TY - JOUR
T1 - Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU)
T2 - 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM
AU - Bassetti, Matteo
AU - Giacobbe, Daniele R
AU - Agvald-Ohman, Christina
AU - Akova, Murat
AU - Alastruey-Izquierdo, Ana
AU - Arikan-Akdagli, Sevtap
AU - Azoulay, Elie
AU - Blot, Stijn
AU - Cornely, Oliver A
AU - Cuenca-Estrella, Manuel
AU - de Lange, Dylan W
AU - De Rosa, Francesco G
AU - De Waele, Jan J
AU - Dimopoulos, George
AU - Garnacho-Montero, Jose
AU - Hoenigl, Martin
AU - Kanj, Souha S
AU - Koehler, Philipp
AU - Kullberg, Bart J
AU - Lamoth, Frédéric
AU - Lass-Flörl, Cornelia
AU - Maertens, Johan
AU - Martin-Loeches, Ignacio
AU - Muñoz, Patricia
AU - Poulakou, Garyphallia
AU - Rello, Jordi
AU - Sanguinetti, Maurizio
AU - Taccone, Fabio S
AU - Timsit, Jean-François
AU - Torres, Antoni
AU - Vazquez, Jose A
AU - Wauters, Joost
AU - Asperges, Erika
AU - Cortegiani, Andrea
AU - Grecchi, Cecilia
AU - Karaiskos, Ilias
AU - Le Bihan, Clément
AU - Mercier, Toine
AU - Mortensen, Klaus L
AU - Peghin, Maddalena
AU - Rebuffi, Chiara
AU - Tejada, Sofia
AU - Vena, Antonio
AU - Zuccaro, Valentina
AU - Scudeller, Luigia
AU - Calandra, Thierry
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/4
Y1 - 2024/4
N2 - PURPOSE: The aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs).METHODS: After a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method.RESULTS: Standardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The limited evidence on the performance of existing definitions and laboratory tests for the diagnosis of IFD other than candidiasis and aspergillosis precluded the development of dedicated definitions, at least pending further data. The standardized definitions provided in the present document are aimed to speed-up the design, and increase the feasibility, of future comparative research studies.
AB - PURPOSE: The aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs).METHODS: After a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method.RESULTS: Standardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The limited evidence on the performance of existing definitions and laboratory tests for the diagnosis of IFD other than candidiasis and aspergillosis precluded the development of dedicated definitions, at least pending further data. The standardized definitions provided in the present document are aimed to speed-up the design, and increase the feasibility, of future comparative research studies.
KW - Aspergillus
KW - Candida
KW - Consensus
KW - Definitions
KW - Diagnosis
KW - Intensive care unit
KW - Invasive fungal diseases
KW - Research
UR - http://www.scopus.com/inward/record.url?scp=85188447746&partnerID=8YFLogxK
U2 - 10.1007/s00134-024-07341-7
DO - 10.1007/s00134-024-07341-7
M3 - Article
C2 - 38512399
SN - 0342-4642
VL - 50
SP - 502
EP - 515
JO - Intensive Care Medicine
JF - Intensive Care Medicine
IS - 4
ER -