Intravenous fat emulsion as an antidote to the veterinary practice Part 1: a literature review

Marieke A. Dijkman; Nieke Van Rhijn; Irma De Vries; Jan Meulenbelt; Joris H. Robben

Intravenous fat emulsion as an antidote to the veterinary practice Part 1: a literature review

Marieke A. Dijkman^*, Nieke Van Rhijn, Irma De Vries, Jan Meulenbelt, Joris H. Robben

^*Corresponding author for this work

Clinical Toxicology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The use of intravenous lipid emulsions (ILE) in human clinical toxicology has become a common practice as life-saving treatment for cardiotoxicity after local anesthetics overdose. The mechanism behind this 'antidotal' effect has not yet been fully elucidated. Case reports indicate ILE may be useful in the resuscitation from toxicity induced by a variety of other lipophilic cardiotoxic drugs like various tricyclic antidepressants (TCA), lipofilic beta-blockers and calcium channel blockers. Several veterinary case reports and case series have demonstrated that ILE are primarily used in the management of long-lasting neurotoxicity like permethrin toxicosis in cats and ivermectin toxicosis in dogs. Treatment with ILE can result in a faster recovery leading to shorter admission times in the veterinary practice. An overview of the current knowledge concerning the use of ILE will be given here.

Original language	English
Pages (from-to)	24-28
Number of pages	5
Journal	Tijdschrift voor Diergeneeskunde
Volume	140
Issue number	5
Publication status	Published - 1 May 2015

Keywords

intravenous lipid emulsion (ILE)
lipophilic drug intoxications
poisoning
cardiotoxicity
neurotoxicity

Cite this

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title = "Intravenous fat emulsion as an antidote to the veterinary practice Part 1: a literature review",

abstract = "The use of intravenous lipid emulsions (ILE) in human clinical toxicology has become a common practice as life-saving treatment for cardiotoxicity after local anesthetics overdose. The mechanism behind this 'antidotal' effect has not yet been fully elucidated. Case reports indicate ILE may be useful in the resuscitation from toxicity induced by a variety of other lipophilic cardiotoxic drugs like various tricyclic antidepressants (TCA), lipofilic beta-blockers and calcium channel blockers. Several veterinary case reports and case series have demonstrated that ILE are primarily used in the management of long-lasting neurotoxicity like permethrin toxicosis in cats and ivermectin toxicosis in dogs. Treatment with ILE can result in a faster recovery leading to shorter admission times in the veterinary practice. An overview of the current knowledge concerning the use of ILE will be given here.",

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author = "Dijkman, {Marieke A.} and {Van Rhijn}, Nieke and {De Vries}, Irma and Jan Meulenbelt and Robben, {Joris H.}",

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T1 - Intravenous fat emulsion as an antidote to the veterinary practice Part 1

T2 - a literature review

AU - Dijkman, Marieke A.

AU - Van Rhijn, Nieke

AU - De Vries, Irma

AU - Meulenbelt, Jan

AU - Robben, Joris H.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - The use of intravenous lipid emulsions (ILE) in human clinical toxicology has become a common practice as life-saving treatment for cardiotoxicity after local anesthetics overdose. The mechanism behind this 'antidotal' effect has not yet been fully elucidated. Case reports indicate ILE may be useful in the resuscitation from toxicity induced by a variety of other lipophilic cardiotoxic drugs like various tricyclic antidepressants (TCA), lipofilic beta-blockers and calcium channel blockers. Several veterinary case reports and case series have demonstrated that ILE are primarily used in the management of long-lasting neurotoxicity like permethrin toxicosis in cats and ivermectin toxicosis in dogs. Treatment with ILE can result in a faster recovery leading to shorter admission times in the veterinary practice. An overview of the current knowledge concerning the use of ILE will be given here.

AB - The use of intravenous lipid emulsions (ILE) in human clinical toxicology has become a common practice as life-saving treatment for cardiotoxicity after local anesthetics overdose. The mechanism behind this 'antidotal' effect has not yet been fully elucidated. Case reports indicate ILE may be useful in the resuscitation from toxicity induced by a variety of other lipophilic cardiotoxic drugs like various tricyclic antidepressants (TCA), lipofilic beta-blockers and calcium channel blockers. Several veterinary case reports and case series have demonstrated that ILE are primarily used in the management of long-lasting neurotoxicity like permethrin toxicosis in cats and ivermectin toxicosis in dogs. Treatment with ILE can result in a faster recovery leading to shorter admission times in the veterinary practice. An overview of the current knowledge concerning the use of ILE will be given here.

KW - intravenous lipid emulsion (ILE)

KW - lipophilic drug intoxications

KW - poisoning

KW - cardiotoxicity

KW - neurotoxicity

M3 - Article

SN - 0040-7453

VL - 140

SP - 24

EP - 28

JO - Tijdschrift voor Diergeneeskunde

JF - Tijdschrift voor Diergeneeskunde

IS - 5

ER -

Intravenous fat emulsion as an antidote to the veterinary practice Part 1: a literature review

Abstract

Keywords

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