Intrathecal glucocorticoids for neuropathic pain

M Rijsdijk

Intrathecal glucocorticoids for neuropathic pain

M Rijsdijk

Anesthesiology

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

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Abstract

In this thesis we have studied the pharmacokinetics, safety and analgesic properties of intrathecal administration of methylprednisolone acetate (MPA) suspension in neuropathic pain states, both in patients and preclinical models. In conclusion, intrathecal MPA does not decrease pain or pain-like behavior in severe neuropathic pain states in patients or rats, respectively, and is a potentially harmful treatment that should not be offered to patients.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Kalkman, CJ, Primary supervisor van Wijck, AJM, Co-supervisor
Award date	26 May 2016
Publisher	Utrecht University
Print ISBNs	978-90-9029700-2
Publication status	Published - 26 May 2016

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title = "Intrathecal glucocorticoids for neuropathic pain",

abstract = "In this thesis we have studied the pharmacokinetics, safety and analgesic properties of intrathecal administration of methylprednisolone acetate (MPA) suspension in neuropathic pain states, both in patients and preclinical models. In conclusion, intrathecal MPA does not decrease pain or pain-like behavior in severe neuropathic pain states in patients or rats, respectively, and is a potentially harmful treatment that should not be offered to patients.",

author = "M Rijsdijk",

note = "Brain Center Rudolf Magnus ; 140",

year = "2016",

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language = "English",

isbn = "978-90-9029700-2",

publisher = "Utrecht University",

type = "Doctoral thesis 1 (Research UU / Graduation UU)",

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T1 - Intrathecal glucocorticoids for neuropathic pain

AU - Rijsdijk, M

N1 - Brain Center Rudolf Magnus ; 140

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N2 - In this thesis we have studied the pharmacokinetics, safety and analgesic properties of intrathecal administration of methylprednisolone acetate (MPA) suspension in neuropathic pain states, both in patients and preclinical models. In conclusion, intrathecal MPA does not decrease pain or pain-like behavior in severe neuropathic pain states in patients or rats, respectively, and is a potentially harmful treatment that should not be offered to patients.

AB - In this thesis we have studied the pharmacokinetics, safety and analgesic properties of intrathecal administration of methylprednisolone acetate (MPA) suspension in neuropathic pain states, both in patients and preclinical models. In conclusion, intrathecal MPA does not decrease pain or pain-like behavior in severe neuropathic pain states in patients or rats, respectively, and is a potentially harmful treatment that should not be offered to patients.

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-90-9029700-2

PB - Utrecht University

ER -

Intrathecal glucocorticoids for neuropathic pain

Abstract

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