Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?

Claire Schwab; Karin Nebral; Lucy Chilton; Cristina Leschi; Esmé Waanders; Judith M Boer; Markéta Žaliová; Rosemary Sutton; Ingegerd Ivanov Öfverholm; Kentaro Ohki; Yuka Yamashita; Stefanie Groeneveld-Krentz; Eva Froňková; Marleen Bakkus; Joelle Tchinda; Thayana da Conceição Barbosa; Grazia Fazio; Wojciech Mlynarski; Agata Pastorczak; Giovanni Cazzaniga; Maria S Pombo-de-Oliveira; Jan Trka; Renate Kirschner-Schwabe; Toshihiko Imamura; Gisela Barbany; Martin Stanulla; Andishe Attarbaschi; Renate Panzer-Grümayer; Roland P Kuiper; Monique L den Boer; Hélène Cavé; Anthony V Moorman; Christine J Harrison; Sabine Strehl

doi:10.1182/bloodadvances.2017006734

Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?

Claire Schwab
, Karin Nebral
, Lucy Chilton
, Cristina Leschi
, Esmé Waanders
, Judith M Boer
, Markéta Žaliová
, Rosemary Sutton
, Ingegerd Ivanov Öfverholm
, Kentaro Ohki
, Yuka Yamashita
, Stefanie Groeneveld-Krentz
, Eva Froňková
, Marleen Bakkus
, Joelle Tchinda
, Thayana da Conceição Barbosa
, Grazia Fazio
, Wojciech Mlynarski
, Agata Pastorczak
, Giovanni Cazzaniga

Maria S Pombo-de-Oliveira, Jan Trka, Renate Kirschner-Schwabe, Toshihiko Imamura, Gisela Barbany, Martin Stanulla, Andishe Attarbaschi, Renate Panzer-Grümayer, Roland P Kuiper, Monique L den Boer, Hélène Cavé, Anthony V Moorman, Christine J Harrison, Sabine Strehl

Section genome diagnostics

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Intragenic PAX5 amplification defines a novel, relapse-prone subtype of B-cell precursor acute lymphoblastic leukemia with a poor outcome.

Original language	English
Pages (from-to)	1473-1477
Number of pages	5
Journal	Blood Advances
Volume	1
Issue number	19
DOIs	https://doi.org/10.1182/bloodadvances.2017006734
Publication status	Published - 22 Aug 2017

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10.1182/bloodadvances.2017006734

advances006734Final published version, 1.04 MBLicence: Taverne

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Schwab, C., Nebral, K., Chilton, L., Leschi, C., Waanders, E., Boer, J. M., Žaliová, M., Sutton, R., Öfverholm, I. I., Ohki, K., Yamashita, Y., Groeneveld-Krentz, S., Froňková, E., Bakkus, M., Tchinda, J., Barbosa, T. D. C., Fazio, G., Mlynarski, W., Pastorczak, A., ... Strehl, S. (2017). Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia? Blood Advances, 1(19), 1473-1477. https://doi.org/10.1182/bloodadvances.2017006734

@article{1394de6285bf4d4b9092d8e3cb38807a,

title = "Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?",

abstract = "Intragenic PAX5 amplification defines a novel, relapse-prone subtype of B-cell precursor acute lymphoblastic leukemia with a poor outcome.",

author = "Claire Schwab and Karin Nebral and Lucy Chilton and Cristina Leschi and Esm{\'e} Waanders and Boer, \{Judith M\} and Mark{\'e}ta {\v Z}aliov{\'a} and Rosemary Sutton and {\"O}fverholm, \{Ingegerd Ivanov\} and Kentaro Ohki and Yuka Yamashita and Stefanie Groeneveld-Krentz and Eva Fro{\v n}kov{\'a} and Marleen Bakkus and Joelle Tchinda and Barbosa, \{Thayana da Concei{\c c}{\~a}o\} and Grazia Fazio and Wojciech Mlynarski and Agata Pastorczak and Giovanni Cazzaniga and Pombo-de-Oliveira, \{Maria S\} and Jan Trka and Renate Kirschner-Schwabe and Toshihiko Imamura and Gisela Barbany and Martin Stanulla and Andishe Attarbaschi and Renate Panzer-Gr{\"u}mayer and Kuiper, \{Roland P\} and \{den Boer\}, \{Monique L\} and H{\'e}l{\`e}ne Cav{\'e} and Moorman, \{Anthony V\} and Harrison, \{Christine J\} and Sabine Strehl",

note = "Funding Information: This work was supported by Bloodwise (formerly Leukaemia and Lymphoma Research) and the Anniversary Fund of the Austrian National Bank (OeNB grant 14133) (K.N.). M.Z., E.F., and J. Trka are supported by NV15-30626A and 00064203 (FN Motol). E.W. is supported by the Dutch Cancer Society (KUN2012-5366). R.S. is supported by National Health and Medical Research Council Australia (APP1057746). M.L.d.B. and J.M.B. are supported by the KiKa Foundation (Kinderen Kankervrij) and the European Union's Seventh Framework Program (FP7/2007-2013) under the project European Network for Cancer Research in Children and Adolescents (ENCCA; grant agreement HEALTH-F2-2011-261474). A.P. was supported by the National Center of Research and Development (LIDER grant 031/635/l-5/13/NCBR/2014). H.C. and C.L. were supported by the European Commission Seventh Framework Programme (FP7) ERA-NET on Translational Cancer Research (TRANSCAN) project TRANSCALL. R.K.-S. is supported by the German Childhood Cancer Foundation (grant DKS 2011.14). G.C. and G.F. are supported by the Italian Association for Cancer Research (AIRC). Funding Information: This work was supported by Bloodwise (formerly Leukaemia and Lymphoma Research) and the Anniversary Fund of the Austrian National Bank (OeNB grant 14133) (K.N.). M.Z., E.F., and J. Trka are supported by NV15-30626A and 00064203 (FN Motol). E.W. is supported by the Dutch Cancer Society (KUN2012-5366). R.S. is supported by National Health and Medical Research Council Australia (APP1057746). M.L.d.B. and J.M.B. are supported by the KiKa Foundation (Kinderen Kankervrij) and the European Union{\textquoteright}s Seventh Framework Program (FP7/2007-2013) under the project European Network for Cancer Research in Children and Adolescents (ENCCA; grant agreement HEALTH-F2-2011-261474). A.P. was supported by the National Center of Research and Development (LIDER grant 031/635/l-5/13/NCBR/2014). H.C. and C.L. were supported by the European Commission Seventh Framework Programme (FP7) ERA-NET on Translational Cancer Research (TRANSCAN) project TRANSCALL. R.K.-S. is supported by the German Childhood Cancer Foundation (grant DKS 2011.14). G.C. and G.F. are supported by the Italian Association for Cancer Research (AIRC).",

year = "2017",

month = aug,

day = "22",

doi = "10.1182/bloodadvances.2017006734",

language = "English",

volume = "1",

pages = "1473--1477",

journal = "Blood Advances",

issn = "2473-9529",

publisher = "American Society of Hematology",

number = "19",

}

Schwab, C, Nebral, K, Chilton, L, Leschi, C, Waanders, E, Boer, JM, Žaliová, M, Sutton, R, Öfverholm, II, Ohki, K, Yamashita, Y, Groeneveld-Krentz, S, Froňková, E, Bakkus, M, Tchinda, J, Barbosa, TDC, Fazio, G, Mlynarski, W, Pastorczak, A, Cazzaniga, G, Pombo-de-Oliveira, MS, Trka, J, Kirschner-Schwabe, R, Imamura, T, Barbany, G, Stanulla, M, Attarbaschi, A, Panzer-Grümayer, R, Kuiper, RP, den Boer, ML, Cavé, H, Moorman, AV, Harrison, CJ & Strehl, S 2017, 'Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?', Blood Advances, vol. 1, no. 19, pp. 1473-1477. https://doi.org/10.1182/bloodadvances.2017006734

TY - JOUR

T1 - Intragenic amplification of PAX5

T2 - a novel subgroup in B-cell precursor acute lymphoblastic leukemia?

AU - Schwab, Claire

AU - Nebral, Karin

AU - Chilton, Lucy

AU - Leschi, Cristina

AU - Waanders, Esmé

AU - Boer, Judith M

AU - Žaliová, Markéta

AU - Sutton, Rosemary

AU - Öfverholm, Ingegerd Ivanov

AU - Ohki, Kentaro

AU - Yamashita, Yuka

AU - Groeneveld-Krentz, Stefanie

AU - Froňková, Eva

AU - Bakkus, Marleen

AU - Tchinda, Joelle

AU - Barbosa, Thayana da Conceição

AU - Fazio, Grazia

AU - Mlynarski, Wojciech

AU - Pastorczak, Agata

AU - Cazzaniga, Giovanni

AU - Pombo-de-Oliveira, Maria S

AU - Trka, Jan

AU - Kirschner-Schwabe, Renate

AU - Imamura, Toshihiko

AU - Barbany, Gisela

AU - Stanulla, Martin

AU - Attarbaschi, Andishe

AU - Panzer-Grümayer, Renate

AU - Kuiper, Roland P

AU - den Boer, Monique L

AU - Cavé, Hélène

AU - Moorman, Anthony V

AU - Harrison, Christine J

AU - Strehl, Sabine

N1 - Funding Information: This work was supported by Bloodwise (formerly Leukaemia and Lymphoma Research) and the Anniversary Fund of the Austrian National Bank (OeNB grant 14133) (K.N.). M.Z., E.F., and J. Trka are supported by NV15-30626A and 00064203 (FN Motol). E.W. is supported by the Dutch Cancer Society (KUN2012-5366). R.S. is supported by National Health and Medical Research Council Australia (APP1057746). M.L.d.B. and J.M.B. are supported by the KiKa Foundation (Kinderen Kankervrij) and the European Union's Seventh Framework Program (FP7/2007-2013) under the project European Network for Cancer Research in Children and Adolescents (ENCCA; grant agreement HEALTH-F2-2011-261474). A.P. was supported by the National Center of Research and Development (LIDER grant 031/635/l-5/13/NCBR/2014). H.C. and C.L. were supported by the European Commission Seventh Framework Programme (FP7) ERA-NET on Translational Cancer Research (TRANSCAN) project TRANSCALL. R.K.-S. is supported by the German Childhood Cancer Foundation (grant DKS 2011.14). G.C. and G.F. are supported by the Italian Association for Cancer Research (AIRC). Funding Information: This work was supported by Bloodwise (formerly Leukaemia and Lymphoma Research) and the Anniversary Fund of the Austrian National Bank (OeNB grant 14133) (K.N.). M.Z., E.F., and J. Trka are supported by NV15-30626A and 00064203 (FN Motol). E.W. is supported by the Dutch Cancer Society (KUN2012-5366). R.S. is supported by National Health and Medical Research Council Australia (APP1057746). M.L.d.B. and J.M.B. are supported by the KiKa Foundation (Kinderen Kankervrij) and the European Union’s Seventh Framework Program (FP7/2007-2013) under the project European Network for Cancer Research in Children and Adolescents (ENCCA; grant agreement HEALTH-F2-2011-261474). A.P. was supported by the National Center of Research and Development (LIDER grant 031/635/l-5/13/NCBR/2014). H.C. and C.L. were supported by the European Commission Seventh Framework Programme (FP7) ERA-NET on Translational Cancer Research (TRANSCAN) project TRANSCALL. R.K.-S. is supported by the German Childhood Cancer Foundation (grant DKS 2011.14). G.C. and G.F. are supported by the Italian Association for Cancer Research (AIRC).

PY - 2017/8/22

Y1 - 2017/8/22

N2 - Intragenic PAX5 amplification defines a novel, relapse-prone subtype of B-cell precursor acute lymphoblastic leukemia with a poor outcome.

AB - Intragenic PAX5 amplification defines a novel, relapse-prone subtype of B-cell precursor acute lymphoblastic leukemia with a poor outcome.

UR - https://www.scopus.com/pages/publications/85058812828

U2 - 10.1182/bloodadvances.2017006734

DO - 10.1182/bloodadvances.2017006734

M3 - Article

C2 - 29296789

SN - 2473-9529

VL - 1

SP - 1473

EP - 1477

JO - Blood Advances

JF - Blood Advances

IS - 19

ER -

Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?

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