Intrafraction motion analysis in online adaptive radiotherapy for esophageal cancer

Mick R Boekhoff; Jan J W Lagendijk; Astrid L H M W van Lier; Stella Mook; Gert J Meijer

doi:10.1016/j.phro.2023.100432

Intrafraction motion analysis in online adaptive radiotherapy for esophageal cancer

Mick R Boekhoff^*, Jan J W Lagendijk, Astrid L H M W van Lier, Stella Mook, Gert J Meijer^*

^*Corresponding author for this work

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Abstract

Intrafraction motion during magnetic resonance (MR)-guided dose delivery of esophageal cancer tumors was retrospectively analyzed. Deformable image registration of cine-MR series resulted in gross tumor volume motion profiles in all directions, which were subsequently filtered to isolate respiratory and drift motion. A large variability in intrafraction motion patterns was observed between patients. Median 95% peak-to-peak motion was 7.7 (3.7 - 18.3) mm, 2.1 (0.7 - 5.7) mm and 2.4 (0.5 - 5.6) mm in cranio-caudal, left-right and anterior-posterior directions, relatively. Furthermore, intrafraction drift was generally modest (<5mm). A patient specific approach could lead to very small margins (<3mm) for most patients.

Original language	English
Article number	100432
Pages (from-to)	1-4
Journal	Physics and Imaging in Radiation Oncology
Volume	26
DOIs	https://doi.org/10.1016/j.phro.2023.100432
Publication status	Published - Apr 2023

Keywords

Esophageal cancer
Intrafraction motion analysis
MR-Linac
MRgRT
Radiotherapy

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title = "Intrafraction motion analysis in online adaptive radiotherapy for esophageal cancer",

abstract = "Intrafraction motion during magnetic resonance (MR)-guided dose delivery of esophageal cancer tumors was retrospectively analyzed. Deformable image registration of cine-MR series resulted in gross tumor volume motion profiles in all directions, which were subsequently filtered to isolate respiratory and drift motion. A large variability in intrafraction motion patterns was observed between patients. Median 95% peak-to-peak motion was 7.7 (3.7 - 18.3) mm, 2.1 (0.7 - 5.7) mm and 2.4 (0.5 - 5.6) mm in cranio-caudal, left-right and anterior-posterior directions, relatively. Furthermore, intrafraction drift was generally modest (<5mm). A patient specific approach could lead to very small margins (<3mm) for most patients.",

keywords = "Esophageal cancer, Intrafraction motion analysis, MR-Linac, MRgRT, Radiotherapy",

author = "Boekhoff, {Mick R} and Lagendijk, {Jan J W} and {van Lier}, {Astrid L H M W} and Stella Mook and Meijer, {Gert J}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = apr,

doi = "10.1016/j.phro.2023.100432",

language = "English",

volume = "26",

pages = "1--4",

journal = "Physics and Imaging in Radiation Oncology",

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T1 - Intrafraction motion analysis in online adaptive radiotherapy for esophageal cancer

AU - Boekhoff, Mick R

AU - Lagendijk, Jan J W

AU - van Lier, Astrid L H M W

AU - Mook, Stella

AU - Meijer, Gert J

PY - 2023/4

Y1 - 2023/4

N2 - Intrafraction motion during magnetic resonance (MR)-guided dose delivery of esophageal cancer tumors was retrospectively analyzed. Deformable image registration of cine-MR series resulted in gross tumor volume motion profiles in all directions, which were subsequently filtered to isolate respiratory and drift motion. A large variability in intrafraction motion patterns was observed between patients. Median 95% peak-to-peak motion was 7.7 (3.7 - 18.3) mm, 2.1 (0.7 - 5.7) mm and 2.4 (0.5 - 5.6) mm in cranio-caudal, left-right and anterior-posterior directions, relatively. Furthermore, intrafraction drift was generally modest (<5mm). A patient specific approach could lead to very small margins (<3mm) for most patients.

AB - Intrafraction motion during magnetic resonance (MR)-guided dose delivery of esophageal cancer tumors was retrospectively analyzed. Deformable image registration of cine-MR series resulted in gross tumor volume motion profiles in all directions, which were subsequently filtered to isolate respiratory and drift motion. A large variability in intrafraction motion patterns was observed between patients. Median 95% peak-to-peak motion was 7.7 (3.7 - 18.3) mm, 2.1 (0.7 - 5.7) mm and 2.4 (0.5 - 5.6) mm in cranio-caudal, left-right and anterior-posterior directions, relatively. Furthermore, intrafraction drift was generally modest (<5mm). A patient specific approach could lead to very small margins (<3mm) for most patients.

KW - Esophageal cancer

KW - Intrafraction motion analysis

KW - MR-Linac

KW - MRgRT

KW - Radiotherapy

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JO - Physics and Imaging in Radiation Oncology

JF - Physics and Imaging in Radiation Oncology

M1 - 100432

ER -

Intrafraction motion analysis in online adaptive radiotherapy for esophageal cancer

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