TY - JOUR
T1 - Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis
T2 - The SMART-MR Study
AU - Zwartbol, M. H. T.
AU - Geerlings, M. I.
AU - Ghaznawi, R.
AU - Hendrikse, J.
AU - van der Kolk, A. G.
AU - Asselbergs, F. W.
AU - Nathoe, H. M.
AU - de Borst, G. J.
AU - Bots, M. L.
AU - Emmelot, M. H.
AU - de Jong, P. A.
AU - Leiner, T.
AU - Lely, A. T.
AU - van der Kaaij, N. P.
AU - Kappelle, L. J.
AU - Ruigrok, Y. M.
AU - Verhaar, M. C.
AU - Visseren, F. L. J.
AU - Westerink, J.
N1 - Funding Information:
Jeroen Hendrikse has received funding from the European Research Council under the European Union's Horizon 2020 Program (H2020)/European Research Council grant agreement No. 637024 (HEARTOFSTROKE) and H2020 grant agreement No. 666881, SVDs@target, and is supported by the Netherlands Organization for Scientific Research under grant No. 91712322.
Funding Information:
Received July 27, 2019; accepted after revision September 24. From the Department of Radiology (M.H.T.Z., R.G., J.H., A.G.v.d.K.) and Julius Center for Health Sciences and Primary Care (M.I.G., R.G.), University Medical Center Utrecht and Utrecht University, Utrecht, the Netherlands. Jeroen Hendrikse has received funding from the European Research Council under the European Union’s Horizon 2020 Program (H2020)/European Research Council grant agreement No. 637024 (HEARTOFSTROKE) and H2020 grant agreement No. 666881, SVDs@target, and is supported by the Netherlands Organization for Scientific Research under grant No. 91712322. Please address correspondence to Mirjam I. Geerlings, PhD, University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, PO Box 85500, Stratenum 6.131, 3508 GA Utrecht, the Netherlands; e-mail: [email protected] Indicates open access to non-subscribers at www.ajnr.org Indicates article with supplemental on-line tables. Indicates article with supplemental on-line photo.
Publisher Copyright:
© 2019 American Society of Neuroradiology. All rights reserved.
PY - 2019/12
Y1 - 2019/12
N2 - BACKGROUND AND PURPOSE: Intracranial atherosclerosis, a major risk factor for ischemic stroke, is thought to have different atherogenic mechanisms than extracranial atherosclerosis. Studies investigating their relationship in vivo are sparse and report inconsistent results. We studied the relationship between intracranial atherosclerosis and extracranial atherosclerosis in a cohort of patients with a history of vascular disease. MATERIALS AND METHODS: Within the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART) study, cross-sectional analyses were performed in 130 patients (mean age, 68 ± 9 years) with a history of vascular disease and with assessable 7T intracranial vessel wall MR imaging data. Intracranial atherosclerosis burden was defined as the number of intracranial vessel wall lesions in the circle of Willis and its major branches. Age- and sex-adjusted unstandardized regression coefficients (b-value) were calculated with intracranial atherosclerosis burden as the dependent variable and extracranial atherosclerosis markers as independent variables. RESULTS: Ninety-six percent of patients had ≥1 vessel wall lesion, with a mean intracranial atherosclerosis burden of 8.5 ± 5.7 lesions. Significant associations were observed between higher intracranial atherosclerosis burden and carotid intima-media thickness (b 4 0.53 lesions per +0.1 mm; 95% CI, 0.1-1.0 lesions), 50%-100% carotid stenosis versus no stenosis (b 4 6.6 lesions; 95% CI, 2.3-10.9 lesions), ankle-brachial index ≤ 0.9 versus >0.9 (b 4 4.9 lesions; 95% CI, 1.7-8.0 lesions), and estimated glomerular filtration rate (b 4 -0.77 lesions per +10 mL/min; 95% CI, -1.50 to -0.03 lesions). No significant differences in intracranial atherosclerosis burden were found among different categories of vascular disease. CONCLUSIONS: Intracranial atherosclerosis was associated with various extracranial markers of atherosclerosis, not supporting a different etiology.
AB - BACKGROUND AND PURPOSE: Intracranial atherosclerosis, a major risk factor for ischemic stroke, is thought to have different atherogenic mechanisms than extracranial atherosclerosis. Studies investigating their relationship in vivo are sparse and report inconsistent results. We studied the relationship between intracranial atherosclerosis and extracranial atherosclerosis in a cohort of patients with a history of vascular disease. MATERIALS AND METHODS: Within the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART) study, cross-sectional analyses were performed in 130 patients (mean age, 68 ± 9 years) with a history of vascular disease and with assessable 7T intracranial vessel wall MR imaging data. Intracranial atherosclerosis burden was defined as the number of intracranial vessel wall lesions in the circle of Willis and its major branches. Age- and sex-adjusted unstandardized regression coefficients (b-value) were calculated with intracranial atherosclerosis burden as the dependent variable and extracranial atherosclerosis markers as independent variables. RESULTS: Ninety-six percent of patients had ≥1 vessel wall lesion, with a mean intracranial atherosclerosis burden of 8.5 ± 5.7 lesions. Significant associations were observed between higher intracranial atherosclerosis burden and carotid intima-media thickness (b 4 0.53 lesions per +0.1 mm; 95% CI, 0.1-1.0 lesions), 50%-100% carotid stenosis versus no stenosis (b 4 6.6 lesions; 95% CI, 2.3-10.9 lesions), ankle-brachial index ≤ 0.9 versus >0.9 (b 4 4.9 lesions; 95% CI, 1.7-8.0 lesions), and estimated glomerular filtration rate (b 4 -0.77 lesions per +10 mL/min; 95% CI, -1.50 to -0.03 lesions). No significant differences in intracranial atherosclerosis burden were found among different categories of vascular disease. CONCLUSIONS: Intracranial atherosclerosis was associated with various extracranial markers of atherosclerosis, not supporting a different etiology.
UR - http://www.scopus.com/inward/record.url?scp=85076506255&partnerID=8YFLogxK
U2 - 10.3174/ajnr.A6308
DO - 10.3174/ajnr.A6308
M3 - Article
C2 - 31806592
SN - 0195-6108
VL - 40
SP - 2016
EP - 2022
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
IS - 12
ER -