Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

V.S. Li; H.C. Clevers

Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

Translated title of the contribution: Intestinal regeneration: YAP-tumor suppressor and oncoprotein?

V.S. Li, H.C. Clevers

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.

Translated title of the contribution	Intestinal regeneration: YAP-tumor suppressor and oncoprotein?
Original language	Undefined/Unknown
Pages (from-to)	R110-2
Number of pages	3
Journal	Current Biology
Volume	23
Issue number	3
Publication status	Published - 2013

Cite this

@article{c3c5732b050541dba21fcb1467c76077,

title = "Intestinal regeneration: YAP-tumor suppressor and oncoprotein?",

abstract = "The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.",

author = "V.S. Li and H.C. Clevers",

year = "2013",

language = "Undefined/Unknown",

volume = "23",

pages = "R110--2",

journal = "Current Biology",

issn = "0960-9822",