TY - JOUR
T1 - Interventions to reduce future cancer incidence from diesel engine exhaust
T2 - What might work?
AU - Carey, Renee N.
AU - Fritschi, Lin
AU - Driscoll, Timothy R.
AU - Peters, Susan
AU - Glass, Deborah C.
AU - Benke, Geza
AU - Reid, Alison
N1 - Funding Information:
The authors would like to thank Ellie Darcey and staff at Safe Work Australia. This study was funded by the National Health and Medical Research Council (NHMRC; grant number 1056684) in partnership with Safe Work Australia, Cancer Council Western Australia (CCWA), and Cancer Council Australia. L. Fritschi is supported by fellowships from NHMRC and CCWA.
Funding Information:
The authors would like to thank Ellie Darcey and staff at Safe Work Australia. This study was funded by the National Health and Medical Research Council (NHMRC; grant number 1056684) in partnership with Safe Work Australia, Cancer Council Western Australia (CCWA),
Publisher Copyright:
©2018 American Association for Cancer Research.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Exposure to diesel engine exhaust (DEE) contributes appreciably to the burden of occupational cancer. This study aims to estimate the potential impact of a range of interventions on the future burden of cancer from occupational exposure to DEE in Australia. The future excess fraction method, a novel method based on the lifetime risk approach, was used to model changes in the future burden of cancer among the Australian working age population exposed to DEE at work in 2012 under various intervention strategies. The interventions modeled were based on the widely accepted hierarchy of control model. At baseline, 600 (0.4%) future bladder and 4,450 (0.6%) future lung cancer cases over the lifetime of the cohort were estimated to be attributable to occupational exposure to DEE in those exposed in 2012. Up to 2,000 of these cases were estimated to be avoidable through the use of various interventions. Exhaust hoses (engineering controls) were estimated to be particularly effective. This study provides an indication of which intervention strategies may be most useful in reducing the future burden of cancer associated with occupational DEE exposure. These results show the potential effect of changing current exposure, rather than focusing on past exposures, and thus provide relevant information for policy planning.
AB - Exposure to diesel engine exhaust (DEE) contributes appreciably to the burden of occupational cancer. This study aims to estimate the potential impact of a range of interventions on the future burden of cancer from occupational exposure to DEE in Australia. The future excess fraction method, a novel method based on the lifetime risk approach, was used to model changes in the future burden of cancer among the Australian working age population exposed to DEE at work in 2012 under various intervention strategies. The interventions modeled were based on the widely accepted hierarchy of control model. At baseline, 600 (0.4%) future bladder and 4,450 (0.6%) future lung cancer cases over the lifetime of the cohort were estimated to be attributable to occupational exposure to DEE in those exposed in 2012. Up to 2,000 of these cases were estimated to be avoidable through the use of various interventions. Exhaust hoses (engineering controls) were estimated to be particularly effective. This study provides an indication of which intervention strategies may be most useful in reducing the future burden of cancer associated with occupational DEE exposure. These results show the potential effect of changing current exposure, rather than focusing on past exposures, and thus provide relevant information for policy planning.
UR - http://www.scopus.com/inward/record.url?scp=85059798547&partnerID=8YFLogxK
U2 - 10.1158/1940-6207.CAPR-18-0274
DO - 10.1158/1940-6207.CAPR-18-0274
M3 - Article
C2 - 30352840
AN - SCOPUS:85059798547
SN - 1940-6207
VL - 12
SP - 13
EP - 20
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 1
ER -