@article{c5eb95283ad04b26a911ae2d3b042038,
title = "Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries",
abstract = "Aims/hypothesis: Gene–macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes. Methods: We investigated the influence of interactions between genetic risk scores (GRSs) for type 2 diabetes, insulin resistance and BMI and macronutrient intake on the development of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct, a prospective case-cohort study across eight European countries (N = 21,900 with 9742 incident type 2 diabetes cases). Macronutrient intake was estimated from diets reported in questionnaires, including proportion of energy derived from total carbohydrate, protein, fat, plant and animal protein, saturated, monounsaturated and polyunsaturated fat and dietary fibre. Using multivariable-adjusted Cox regression, we estimated country-specific interaction results on the multiplicative scale, using random-effects meta-analysis. Secondary analysis used isocaloric macronutrient substitution. Results: No interactions were identified between any of the three GRSs and any macronutrient intake, with low-to-moderate heterogeneity between countries (I2 range 0–51.6%). Results were similar using isocaloric macronutrient substitution analyses and when weighted and unweighted GRSs and individual SNPs were examined. Conclusions/interpretation: Genetic susceptibility to type 2 diabetes, insulin resistance and BMI did not modify the association between macronutrient intake and incident type 2 diabetes. This suggests that macronutrient intake recommendations to prevent type 2 diabetes do not need to account for differences in genetic predisposition to these three metabolic conditions.",
keywords = "BMI, Body mass index, Diabetes, Diet, Dietary fibre, Genetic risk score, GRS, Insulin resistance, Interaction, Macronutrient",
author = "Li, {Sherly X.} and Fumiaki Imamura and Schulze, {Matthias B.} and Jusheng Zheng and Zheng Ye and Antonio Agudo and Eva Ardanaz and Dagfinn Aune and Heiner Boeing and Miren Dorronsoro and Courtney Dow and Guy Fagherazzi and Sara Grioni and Gunter, {Marc J.} and Huerta, {Jos{\'e} Mar{\'i}a} and Ibsen, {Daniel B.} and Jakobsen, {Marianne Uhre} and Rudolf Kaaks and Key, {Timothy J.} and Khaw, {Kay Tee} and Cecilie Kyr{\o} and Mancini, {Francesca Romana} and Elena Molina-Portillo and Neil Murphy and Nilsson, {Peter M.} and Onland-Moret, {N. Charlotte} and Domenico Palli and Salvatore Panico and Alaitz Poveda and Quir{\'o}s, {J. Ram{\'o}n} and Fulvio Ricceri and Ivonne Sluijs and Spijkerman, {Annemieke M.W.} and Anne Tjonneland and Rosario Tumino and Anna Winkvist and Claudia Langenberg and Sharp, {Stephen J.} and Elio Riboli and Scott, {Robert A.} and Forouhi, {Nita G.} and Wareham, {Nicholas J.}",
note = "Funding Information: We thank all participants and staff who contributed to the study within their respective EPIC centres. We thank N. Kerrison of the Medical Research Council (MRC) Epidemiology Unit, Cambridge, UK for managing the data for the InterAct project. We thank staff from the Technical, Field Epidemiology and Data Functional Group Teams of the MRC Epidemiology Unit in Cambridge for carrying out sample preparation, DNA provision and quality control, genotyping and data-handling work. S.X. Li thanks the Commonwealth Scholarship Commission and the Cambridge Trust for supporting her PhD studies. Nita G. Forouhi and Nicholas J. Wareham are joint senior authors. The authors declare that there is no duality of interest associated with this manuscript. Funding Information: Funding The InterAct project is supported by the EU Sixth Framework Programme (FP6) (grant LSHM_CT_2006_037197). The InterAct investigators acknowledge support from the Medical Research Council Epidemiology Unit (grants MC_UU_12015/1 and MC_UU_12015/5), Medical Research Council Human Nutrition Research (grant MC_UP_ A090_1006) and Cambridge Lipidomics Biomarker Research Initiative (grant G0800783). NJW and NGF acknowledge IS-BRC-1215-20014 funding support from NIHR Biomedical Research Centre Cambridge. MBS was supported by a grant from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD) and the State of Brandenburg. Support was also provided by the following bodies: Health Research Fund (FIS) of the Spanish Ministry of Health and Navarre Regional Government (to EA); Health Research Fund of the Spanish Ministry of Health and Murcia Regional Government (No. 6236) (to JMH); German Cancer Aid, German Ministry of Research (BMBF) (to RK); Cancer Research UK C8221/ A19170 and Medical Research Council MR/M012190/1 (to TJK); Medical Research Council UK and Cancer Research UK (to KTK); Swedish Research Council (to PMN); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) and Statistics Netherlands (to NCOM, IS, AMWS and EPIC Bilthoven and Utrecht); Compagnia di San Paolo (to SP); Regional Government of Asturias (to JRQ); Danish Cancer Society (to AT); Sicilian Regional Government and AIRE-ONLUS Ragusa (to RT and EPIC Ragusa) and Imperial College Biomedical Research Centre (to ER). Verification of diabetes cases in EPIC-NL was additionally funded by NL Agency grant IGE05012 and an Incentive Grant from the Board of the UMC Utrecht. Funding Information: Acknowledgements We thank all participants and staff who contributed to the study within their respective EPIC centres. We thank N. Kerrison of the Medical Research Council (MRC) Epidemiology Unit, Cambridge, UK for managing the data for the InterAct project. We thank staff from the Technical, Field Epidemiology and Data Functional Group Teams of the MRC Epidemiology Unit in Cambridge for carrying out sample preparation, DNA provision and quality control, genotyping and data-handling work. S.X. Li thanks the Commonwealth Scholarship Commission and the Cambridge Trust for supporting her PhD studies. Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = jun,
day = "1",
doi = "10.1007/s00125-018-4586-2",
language = "English",
volume = "61",
pages = "1325--1332",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer-Verlag",
number = "6",
}