Interobserver variability in chest CT and whole body FDG-PET screening for distant metastases in head and neck cancer patients

Asaf Senft; Remco De Bree; Richard P. Golding; Emile F.I. Comans; Jan Hein T.M. Van Waesberghe; J. Dirk Kuik; Otto S. Hoekstra; C. René Leemans

doi:10.1007/s11307-010-0354-5

Interobserver variability in chest CT and whole body FDG-PET screening for distant metastases in head and neck cancer patients

Asaf Senft, Remco De Bree^*, Richard P. Golding, Emile F.I. Comans, Jan Hein T.M. Van Waesberghe, J. Dirk Kuik, Otto S. Hoekstra, C. René Leemans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

Purpose: The aim of the study was to assess the interobserver variability in chest computed tomography (CT) and whole body 2-deoxy-2-[ ¹⁸F] fluoro-D-glucose positron emission tomography (FDG-PET) screening for distant metastases in head and neck squamous cell carcinoma (HNSCC) patients. Procedure: Chest CT and whole body FDG-PET of 69 HNSCC patients with high-risk factors who underwent screening for distant metastases were analyzed. All scans were independently read by two experienced radiologists or nuclear physicians who were blinded to the other examinations and follow-up results. Results: A kappa of 0.516 was found for assessment of size on CT. Kappa values for origin and susceptibility of 0.406 and 0.512 for CT and 0.834 and 0.939 for PET were found, respectively. The overall conclusions had a kappa of 0.517-0.634 for CT and 0.820-1.000 for PET. Conclusions: In screening for distant metastases in HNSCC patients with high-risk factors, chest CT readings had a reasonable to substantial agreement, while PET readings showed an almost perfect agreement. These findings suggest that for optimal assessment in clinical practice, PET most often can be scored by one observer, but CT should probably more often be scored by different observers in consensus or combined with PET.

Original language	English
Pages (from-to)	385-390
Number of pages	6
Journal	Molecular Imaging and Biology
Volume	13
Issue number	2
DOIs	https://doi.org/10.1007/s11307-010-0354-5
Publication status	Published - 1 Apr 2011

Keywords

CT
Distant metastases
FDG-PET
Head and neck cancer
Interobserver agreement

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title = "Interobserver variability in chest CT and whole body FDG-PET screening for distant metastases in head and neck cancer patients",

abstract = "Purpose: The aim of the study was to assess the interobserver variability in chest computed tomography (CT) and whole body 2-deoxy-2-[ 18F] fluoro-D-glucose positron emission tomography (FDG-PET) screening for distant metastases in head and neck squamous cell carcinoma (HNSCC) patients. Procedure: Chest CT and whole body FDG-PET of 69 HNSCC patients with high-risk factors who underwent screening for distant metastases were analyzed. All scans were independently read by two experienced radiologists or nuclear physicians who were blinded to the other examinations and follow-up results. Results: A kappa of 0.516 was found for assessment of size on CT. Kappa values for origin and susceptibility of 0.406 and 0.512 for CT and 0.834 and 0.939 for PET were found, respectively. The overall conclusions had a kappa of 0.517-0.634 for CT and 0.820-1.000 for PET. Conclusions: In screening for distant metastases in HNSCC patients with high-risk factors, chest CT readings had a reasonable to substantial agreement, while PET readings showed an almost perfect agreement. These findings suggest that for optimal assessment in clinical practice, PET most often can be scored by one observer, but CT should probably more often be scored by different observers in consensus or combined with PET.",

keywords = "CT, Distant metastases, FDG-PET, Head and neck cancer, Interobserver agreement",

author = "Asaf Senft and {De Bree}, Remco and Golding, {Richard P.} and Comans, {Emile F.I.} and {Van Waesberghe}, {Jan Hein T.M.} and Kuik, {J. Dirk} and Hoekstra, {Otto S.} and Leemans, {C. Ren{\'e}}",

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doi = "10.1007/s11307-010-0354-5",

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T1 - Interobserver variability in chest CT and whole body FDG-PET screening for distant metastases in head and neck cancer patients

AU - Senft, Asaf

AU - De Bree, Remco

AU - Golding, Richard P.

AU - Comans, Emile F.I.

AU - Van Waesberghe, Jan Hein T.M.

AU - Kuik, J. Dirk

AU - Hoekstra, Otto S.

AU - Leemans, C. René

PY - 2011/4/1

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N2 - Purpose: The aim of the study was to assess the interobserver variability in chest computed tomography (CT) and whole body 2-deoxy-2-[ 18F] fluoro-D-glucose positron emission tomography (FDG-PET) screening for distant metastases in head and neck squamous cell carcinoma (HNSCC) patients. Procedure: Chest CT and whole body FDG-PET of 69 HNSCC patients with high-risk factors who underwent screening for distant metastases were analyzed. All scans were independently read by two experienced radiologists or nuclear physicians who were blinded to the other examinations and follow-up results. Results: A kappa of 0.516 was found for assessment of size on CT. Kappa values for origin and susceptibility of 0.406 and 0.512 for CT and 0.834 and 0.939 for PET were found, respectively. The overall conclusions had a kappa of 0.517-0.634 for CT and 0.820-1.000 for PET. Conclusions: In screening for distant metastases in HNSCC patients with high-risk factors, chest CT readings had a reasonable to substantial agreement, while PET readings showed an almost perfect agreement. These findings suggest that for optimal assessment in clinical practice, PET most often can be scored by one observer, but CT should probably more often be scored by different observers in consensus or combined with PET.

AB - Purpose: The aim of the study was to assess the interobserver variability in chest computed tomography (CT) and whole body 2-deoxy-2-[ 18F] fluoro-D-glucose positron emission tomography (FDG-PET) screening for distant metastases in head and neck squamous cell carcinoma (HNSCC) patients. Procedure: Chest CT and whole body FDG-PET of 69 HNSCC patients with high-risk factors who underwent screening for distant metastases were analyzed. All scans were independently read by two experienced radiologists or nuclear physicians who were blinded to the other examinations and follow-up results. Results: A kappa of 0.516 was found for assessment of size on CT. Kappa values for origin and susceptibility of 0.406 and 0.512 for CT and 0.834 and 0.939 for PET were found, respectively. The overall conclusions had a kappa of 0.517-0.634 for CT and 0.820-1.000 for PET. Conclusions: In screening for distant metastases in HNSCC patients with high-risk factors, chest CT readings had a reasonable to substantial agreement, while PET readings showed an almost perfect agreement. These findings suggest that for optimal assessment in clinical practice, PET most often can be scored by one observer, but CT should probably more often be scored by different observers in consensus or combined with PET.

KW - CT

KW - Distant metastases

KW - FDG-PET

KW - Head and neck cancer

KW - Interobserver agreement

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JO - Molecular Imaging and Biology

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ER -

Interobserver variability in chest CT and whole body FDG-PET screening for distant metastases in head and neck cancer patients

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