International variation in the management of severe COVID-19 patients

Elie Azoulay; Jan de Waele; Ricard Ferrer; Thomas Staudinger; Marta Borkowska; Pedro Povoa; Katerina Iliopoulou; Antonio Artigas; Stefan J Schaller; Manu Shankar-Hari; Mariangela Pellegrini; Michael Darmon; Jozef Kesecioglu; Maurizio Cecconi

doi:10.1186/s13054-020-03194-w

International variation in the management of severe COVID-19 patients

Elie Azoulay, Jan de Waele, Ricard Ferrer, Thomas Staudinger, Marta Borkowska, Pedro Povoa, Katerina Iliopoulou, Antonio Artigas, Stefan J Schaller, Manu Shankar-Hari, Mariangela Pellegrini, Michael Darmon, Jozef Kesecioglu, Maurizio Cecconi

Research output: Contribution to journal › Article › Academic › peer-review

13 Downloads (Pure)

Abstract

BACKGROUND: There is little evidence to support the management of severe COVID-19 patients.

METHODS: To document this variation in practices, we performed an online survey (April 30-May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). A case vignette was sent to ESICM members. Questions investigated practices for a previously healthy 39-year-old patient presenting with severe hypoxemia from COVID-19 infection.

RESULTS: A total of 1132 ICU specialists (response rate 20%) from 85 countries (12 regions) responded to the survey. The survey provides information on the heterogeneity in patient's management, more particularly regarding the timing of ICU admission, the first line oxygenation strategy, optimization of management, and ventilatory settings in case of refractory hypoxemia. Practices related to antibacterial, antiviral, and anti-inflammatory therapies are also investigated.

CONCLUSIONS: There are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. Large outcome studies based on multinational registries are warranted.

Original language	English
Article number	486
Journal	Critical care (London, England)
Volume	24
Issue number	1
DOIs	https://doi.org/10.1186/s13054-020-03194-w
Publication status	Published - 5 Aug 2020

Keywords

Acute respiratory distress syndrome
Coronavirus
Remdesivir
Viral infection

Access to Document

10.1186/s13054-020-03194-w

s13054-020-03194-wFinal published version, 1.42 MB

Cite this

Azoulay, E., de Waele, J., Ferrer, R., Staudinger, T., Borkowska, M., Povoa, P., Iliopoulou, K., Artigas, A., Schaller, S. J., Shankar-Hari, M., Pellegrini, M., Darmon, M., Kesecioglu, J., & Cecconi, M. (2020). International variation in the management of severe COVID-19 patients. Critical care (London, England), 24(1), Article 486. https://doi.org/10.1186/s13054-020-03194-w

@article{903e53671afa40348a41b50be2df2b69,

title = "International variation in the management of severe COVID-19 patients",

abstract = "BACKGROUND: There is little evidence to support the management of severe COVID-19 patients.METHODS: To document this variation in practices, we performed an online survey (April 30-May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). A case vignette was sent to ESICM members. Questions investigated practices for a previously healthy 39-year-old patient presenting with severe hypoxemia from COVID-19 infection.RESULTS: A total of 1132 ICU specialists (response rate 20%) from 85 countries (12 regions) responded to the survey. The survey provides information on the heterogeneity in patient's management, more particularly regarding the timing of ICU admission, the first line oxygenation strategy, optimization of management, and ventilatory settings in case of refractory hypoxemia. Practices related to antibacterial, antiviral, and anti-inflammatory therapies are also investigated.CONCLUSIONS: There are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. Large outcome studies based on multinational registries are warranted.",

keywords = "Acute respiratory distress syndrome, Coronavirus, Remdesivir, Viral infection",

author = "Elie Azoulay and {de Waele}, Jan and Ricard Ferrer and Thomas Staudinger and Marta Borkowska and Pedro Povoa and Katerina Iliopoulou and Antonio Artigas and Schaller, {Stefan J} and Manu Shankar-Hari and Mariangela Pellegrini and Michael Darmon and Jozef Kesecioglu and Maurizio Cecconi",

year = "2020",

month = aug,

day = "5",

doi = "10.1186/s13054-020-03194-w",

language = "English",

volume = "24",

journal = "Critical care (London, England)",

issn = "1466-609X",

publisher = "Springer Science + Business Media",

number = "1",

}

TY - JOUR

T1 - International variation in the management of severe COVID-19 patients

AU - Azoulay, Elie

AU - de Waele, Jan

AU - Ferrer, Ricard

AU - Staudinger, Thomas

AU - Borkowska, Marta

AU - Povoa, Pedro

AU - Iliopoulou, Katerina

AU - Artigas, Antonio

AU - Schaller, Stefan J

AU - Shankar-Hari, Manu

AU - Pellegrini, Mariangela

AU - Darmon, Michael

AU - Kesecioglu, Jozef

AU - Cecconi, Maurizio

PY - 2020/8/5

Y1 - 2020/8/5

N2 - BACKGROUND: There is little evidence to support the management of severe COVID-19 patients.METHODS: To document this variation in practices, we performed an online survey (April 30-May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). A case vignette was sent to ESICM members. Questions investigated practices for a previously healthy 39-year-old patient presenting with severe hypoxemia from COVID-19 infection.RESULTS: A total of 1132 ICU specialists (response rate 20%) from 85 countries (12 regions) responded to the survey. The survey provides information on the heterogeneity in patient's management, more particularly regarding the timing of ICU admission, the first line oxygenation strategy, optimization of management, and ventilatory settings in case of refractory hypoxemia. Practices related to antibacterial, antiviral, and anti-inflammatory therapies are also investigated.CONCLUSIONS: There are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. Large outcome studies based on multinational registries are warranted.

AB - BACKGROUND: There is little evidence to support the management of severe COVID-19 patients.METHODS: To document this variation in practices, we performed an online survey (April 30-May 25, 2020) on behalf of the European Society of Intensive Care Medicine (ESICM). A case vignette was sent to ESICM members. Questions investigated practices for a previously healthy 39-year-old patient presenting with severe hypoxemia from COVID-19 infection.RESULTS: A total of 1132 ICU specialists (response rate 20%) from 85 countries (12 regions) responded to the survey. The survey provides information on the heterogeneity in patient's management, more particularly regarding the timing of ICU admission, the first line oxygenation strategy, optimization of management, and ventilatory settings in case of refractory hypoxemia. Practices related to antibacterial, antiviral, and anti-inflammatory therapies are also investigated.CONCLUSIONS: There are important practice variations in the management of severe COVID-19 patients, including differences at regional and individual levels. Large outcome studies based on multinational registries are warranted.

KW - Acute respiratory distress syndrome

KW - Coronavirus

KW - Remdesivir

KW - Viral infection

UR - http://www.scopus.com/inward/record.url?scp=85089170472&partnerID=8YFLogxK

U2 - 10.1186/s13054-020-03194-w

DO - 10.1186/s13054-020-03194-w

M3 - Article

C2 - 32758266

SN - 1466-609X

VL - 24

JO - Critical care (London, England)

JF - Critical care (London, England)

IS - 1

M1 - 486

ER -

International variation in the management of severe COVID-19 patients

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this