International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Ruth T. Casey; Emile Hendriks; Cheri Deal; Steven G. Waguespack; Verena Wiegering; Antje Redlich; Scott Akker; Rathi Prasad; Martin Fassnacht; Roderick Clifton-Bligh; Laurence Amar; Stefan Bornstein; Letizia Canu; Evangelia Charmandari; Alexandra Chrisoulidou; Maria Currás Freixes; Ronald de Krijger; Luisa de Sanctis; Antonio Fojo; Amol J. Ghia; Angela Huebner; Vasilis Kosmoliaptsis; Michaela Kuehlen; Marco Raffaelli; Charlotte Lussey-Lepoutre; Stephen D. Marks; Naris Nilubol; Mirko Parasiliti-Caprino; Henri H.J.L.M. Timmers; Anna Lena Zietlow; Mercedes Robledo; Anne Paule Gimenez-Roqueplo; Ashley B. Grossman; David Taïeb; Eamonn R. Maher; Jacques W.M. Lenders; Graeme Eisenhofer; Camilo Jimenez; Karel Pacak; Christina Pamporaki

doi:10.1038/s41574-024-01024-5

International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Ruth T. Casey^*, Emile Hendriks, Cheri Deal, Steven G. Waguespack, Verena Wiegering, Antje Redlich, Scott Akker, Rathi Prasad, Martin Fassnacht, Roderick Clifton-Bligh, Laurence Amar, Stefan Bornstein, Letizia Canu, Evangelia Charmandari, Alexandra Chrisoulidou, Maria Currás Freixes, Ronald de Krijger, Luisa de Sanctis, Antonio Fojo, Amol J. GhiaAngela Huebner, Vasilis Kosmoliaptsis, Michaela Kuehlen, Marco Raffaelli, Charlotte Lussey-Lepoutre, Stephen D. Marks, Naris Nilubol, Mirko Parasiliti-Caprino, Henri H.J.L.M. Timmers, Anna Lena Zietlow, Mercedes Robledo, Anne Paule Gimenez-Roqueplo, Ashley B. Grossman, David Taïeb, Eamonn R. Maher, Jacques W.M. Lenders, Graeme Eisenhofer, Camilo Jimenez, Karel Pacak, Christina Pamporaki^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

Original language	English
Pages (from-to)	729-748
Number of pages	20
Journal	Nature Reviews Endocrinology
Volume	20
Issue number	12
Early online date	15 Aug 2024
DOIs	https://doi.org/10.1038/s41574-024-01024-5
Publication status	Published - Dec 2024

Access to Document

10.1038/s41574-024-01024-5

Cite this

Casey, R. T., Hendriks, E., Deal, C., Waguespack, S. G., Wiegering, V., Redlich, A., Akker, S., Prasad, R., Fassnacht, M., Clifton-Bligh, R., Amar, L., Bornstein, S., Canu, L., Charmandari, E., Chrisoulidou, A., Freixes, M. C., de Krijger, R., de Sanctis, L., Fojo, A., ... Pamporaki, C. (2024). International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents. Nature Reviews Endocrinology, 20(12), 729-748. https://doi.org/10.1038/s41574-024-01024-5

@article{f5bf65e3b2b74704be1813c87bdb3a40,

title = "International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents",

abstract = "Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.",

author = "Casey, {Ruth T.} and Emile Hendriks and Cheri Deal and Waguespack, {Steven G.} and Verena Wiegering and Antje Redlich and Scott Akker and Rathi Prasad and Martin Fassnacht and Roderick Clifton-Bligh and Laurence Amar and Stefan Bornstein and Letizia Canu and Evangelia Charmandari and Alexandra Chrisoulidou and Freixes, {Maria Curr{\'a}s} and {de Krijger}, Ronald and {de Sanctis}, Luisa and Antonio Fojo and Ghia, {Amol J.} and Angela Huebner and Vasilis Kosmoliaptsis and Michaela Kuehlen and Marco Raffaelli and Charlotte Lussey-Lepoutre and Marks, {Stephen D.} and Naris Nilubol and Mirko Parasiliti-Caprino and Timmers, {Henri H.J.L.M.} and Zietlow, {Anna Lena} and Mercedes Robledo and Gimenez-Roqueplo, {Anne Paule} and Grossman, {Ashley B.} and David Ta{\"i}eb and Maher, {Eamonn R.} and Lenders, {Jacques W.M.} and Graeme Eisenhofer and Camilo Jimenez and Karel Pacak and Christina Pamporaki",

note = "Publisher Copyright: {\textcopyright} Crown 2024. corrected publication 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41574-024-01024-5",

language = "English",

volume = "20",

pages = "729--748",

journal = "Nature Reviews Endocrinology",

issn = "1759-5029",

publisher = "Nature Publishing Group",

number = "12",

}

Casey, RT, Hendriks, E, Deal, C, Waguespack, SG, Wiegering, V, Redlich, A, Akker, S, Prasad, R, Fassnacht, M, Clifton-Bligh, R, Amar, L, Bornstein, S, Canu, L, Charmandari, E, Chrisoulidou, A, Freixes, MC, de Krijger, R, de Sanctis, L, Fojo, A, Ghia, AJ, Huebner, A, Kosmoliaptsis, V, Kuehlen, M, Raffaelli, M, Lussey-Lepoutre, C, Marks, SD, Nilubol, N, Parasiliti-Caprino, M, Timmers, HHJLM, Zietlow, AL, Robledo, M, Gimenez-Roqueplo, AP, Grossman, AB, Taïeb, D, Maher, ER, Lenders, JWM, Eisenhofer, G, Jimenez, C, Pacak, K & Pamporaki, C 2024, 'International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents', Nature Reviews Endocrinology, vol. 20, no. 12, pp. 729-748. https://doi.org/10.1038/s41574-024-01024-5

TY - JOUR

T1 - International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

AU - Casey, Ruth T.

AU - Hendriks, Emile

AU - Deal, Cheri

AU - Waguespack, Steven G.

AU - Wiegering, Verena

AU - Redlich, Antje

AU - Akker, Scott

AU - Prasad, Rathi

AU - Fassnacht, Martin

AU - Clifton-Bligh, Roderick

AU - Amar, Laurence

AU - Bornstein, Stefan

AU - Canu, Letizia

AU - Charmandari, Evangelia

AU - Chrisoulidou, Alexandra

AU - Freixes, Maria Currás

AU - de Krijger, Ronald

AU - de Sanctis, Luisa

AU - Fojo, Antonio

AU - Ghia, Amol J.

AU - Huebner, Angela

AU - Kosmoliaptsis, Vasilis

AU - Kuehlen, Michaela

AU - Raffaelli, Marco

AU - Lussey-Lepoutre, Charlotte

AU - Marks, Stephen D.

AU - Nilubol, Naris

AU - Parasiliti-Caprino, Mirko

AU - Timmers, Henri H.J.L.M.

AU - Zietlow, Anna Lena

AU - Robledo, Mercedes

AU - Gimenez-Roqueplo, Anne Paule

AU - Grossman, Ashley B.

AU - Taïeb, David

AU - Maher, Eamonn R.

AU - Lenders, Jacques W.M.

AU - Eisenhofer, Graeme

AU - Jimenez, Camilo

AU - Pacak, Karel

AU - Pamporaki, Christina

PY - 2024/12

Y1 - 2024/12

N2 - Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

AB - Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

UR - http://www.scopus.com/inward/record.url?scp=85201542262&partnerID=8YFLogxK

U2 - 10.1038/s41574-024-01024-5

DO - 10.1038/s41574-024-01024-5

M3 - Article

C2 - 39147856

AN - SCOPUS:85201542262

SN - 1759-5029

VL - 20

SP - 729

EP - 748

JO - Nature Reviews Endocrinology

JF - Nature Reviews Endocrinology

IS - 12

ER -

International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Abstract

Access to Document

Other files and links

Fingerprint

Author Correction: International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents (Nature Reviews Endocrinology, (2024), 20, 12, (729-748), 10.1038/s41574-024-01024-5)

Cite this