International consensus on laryngeal preservation strategies in laryngeal and hypopharyngeal cancer

Marco Ferrari; Francesca Mularoni; Davide Smussi; Piergiorgio Gaudioso; Pierluigi Bonomo; Jeppe Friborg; Maria Grazia Ghi; Vincent Gregoire; Kevin Harrington; Keith Hunter; Roberto Maroldi; Rosemary Martino; Ricard Mesia; Giorgio Peretti; Amanda Psyrri; Antonio Schindler; Giovanni Succo; Petr Szturz; Isabel Vilaseca; Piero Nicolai; Paolo Bossi; Jai Prakash Agarwal; Mohssen Ansarin; Athanassios Argiris; Panagiotis Balermpas; Nicolò Matteo Luca Battisti; Elisa Bellini; Andy Bertolin; Andrea Luigi Camillo Carobbio; Carlos Miguel Chiesa-Estomba; Beatriz Cirauqui; Erika Crosetti; Thiago Bueno De Oliveira; Alberto Deganello; Andreas Dietz; Jesper Grau Eriksen; Antoine Eskander; Nicolas Fakhry; Agustin Falco; Davide Farina; Renata Ferrarotto; Ciro Franzese; Sarbani Ghosh Laskar; Wojciech Golusiński; Ehab Yn Hanna; Jonathan Crawford Irish; Naomi Kiyota; Luiz Paulo Kowalski; Suren Krishnan; Nancy Lee; C. René Leemans; Lisa Licitra; Laura Deborah Locati; Jean Pascal Machiels; Filippo Marchi; Davide Mattavelli; Hisham Mehanna; Giuseppe Mercante; Nausica Montalto; Patrizia Morbini; Brian O'Sullivan; Marc Oliva; Ester Orlandi; Alberto Paderno; Vinidh Paleri; Frank Pameijer; Francesco Perri; Roberto Persio; Cesare Piazza; Yoann Pointreau; Livio Presutti; Marco Ravanelli; Danny Rischin; Juan Pablo Rodrigo; Alessandra Ruaro; Giuseppe Sanguineti; Christian Simon; Lillian Siu; Anna Spreafico; Giuseppe Spriano; Stefano Taboni; Umberto Tassini; Silke Tribius; Michiel Van den Brekel; Vincent Vander Poorten; David Viros Porcuna

doi:10.1016/S1470-2045(25)00020-8

International consensus on laryngeal preservation strategies in laryngeal and hypopharyngeal cancer

Marco Ferrari^*
, Francesca Mularoni
, Davide Smussi
, Piergiorgio Gaudioso
, Pierluigi Bonomo
, Jeppe Friborg
, Maria Grazia Ghi
, Vincent Gregoire
, Kevin Harrington
, Keith Hunter
, Roberto Maroldi
, Rosemary Martino
, Ricard Mesia
, Giorgio Peretti
, Amanda Psyrri
, Antonio Schindler
, Giovanni Succo
, Petr Szturz
, Isabel Vilaseca
, Piero Nicolai

Paolo Bossi^*, Jai Prakash Agarwal, Mohssen Ansarin, Athanassios Argiris, Panagiotis Balermpas, Nicolò Matteo Luca Battisti, Elisa Bellini, Andy Bertolin, Andrea Luigi Camillo Carobbio, Carlos Miguel Chiesa-Estomba, Beatriz Cirauqui, Erika Crosetti, Thiago Bueno De Oliveira, Alberto Deganello, Andreas Dietz, Jesper Grau Eriksen, Antoine Eskander, Nicolas Fakhry, Agustin Falco, Davide Farina, Renata Ferrarotto, Ciro Franzese, Sarbani Ghosh Laskar, Wojciech Golusiński, Ehab Yn Hanna, Jonathan Crawford Irish, Naomi Kiyota, Luiz Paulo Kowalski, Suren Krishnan, Nancy Lee, C. René Leemans, Lisa Licitra, Laura Deborah Locati, Jean Pascal Machiels, Filippo Marchi, Davide Mattavelli, Hisham Mehanna, Giuseppe Mercante, Nausica Montalto, Patrizia Morbini, Brian O'Sullivan, Marc Oliva, Ester Orlandi, Alberto Paderno, Vinidh Paleri, Frank Pameijer, Francesco Perri, Roberto Persio, Cesare Piazza, Yoann Pointreau, Livio Presutti, Marco Ravanelli, Danny Rischin, Juan Pablo Rodrigo, Alessandra Ruaro, Giuseppe Sanguineti, Christian Simon, Lillian Siu, Anna Spreafico, Giuseppe Spriano, Stefano Taboni, Umberto Tassini, Silke Tribius, Michiel Van den Brekel, Vincent Vander Poorten, David Viros Porcuna

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

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Abstract

This Policy Review summarises an expert Delphi consensus process on larynx-preservation treatments in patients affected by intermediate-to-advanced laryngeal or hypopharyngeal squamous cell carcinoma. The experts, who represented all perspectives involved in multidisciplinary management of these patients and included patient representatives, approved 137 consensus statements that cover several relevant areas in the field of larynx-preserving treatments. Statements are grouped in the following topics: granular indications for T2–T3 cancer, indications for T4a cancer, indications for salvage organ-preservation surgery after chemoradiation failure, laryngeal function at baseline, which comorbidities are contraindications and to what extent, organ preservation in older patients: selection criteria, post-treatment surveillance, prognostic and predictive factors, listening to the patient's preferences: tools and implementation, prehabilitation and rehabilitation protocols, and cost-effectiveness of different laryngeal preservation approaches. We present a high-level summary of the results of the consensus process, with detailed reference to the full list of statements and supporting literature.

Original language	English
Pages (from-to)	e264-e281
Journal	The Lancet Oncology
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/S1470-2045(25)00020-8
Publication status	Published - May 2025

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10.1016/S1470-2045(25)00020-8

International consensus on laryngeal preservation strategies in laryngeal and hypopharyngeal cancerFinal published version, 485 KBLicence: Taverne

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Ferrari, M., Mularoni, F., Smussi, D., Gaudioso, P., Bonomo, P., Friborg, J., Ghi, M. G., Gregoire, V., Harrington, K., Hunter, K., Maroldi, R., Martino, R., Mesia, R., Peretti, G., Psyrri, A., Schindler, A., Succo, G., Szturz, P., Vilaseca, I., ... Viros Porcuna, D. (2025). International consensus on laryngeal preservation strategies in laryngeal and hypopharyngeal cancer. The Lancet Oncology, 26(5), e264-e281. https://doi.org/10.1016/S1470-2045(25)00020-8

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title = "International consensus on laryngeal preservation strategies in laryngeal and hypopharyngeal cancer",

abstract = "This Policy Review summarises an expert Delphi consensus process on larynx-preservation treatments in patients affected by intermediate-to-advanced laryngeal or hypopharyngeal squamous cell carcinoma. The experts, who represented all perspectives involved in multidisciplinary management of these patients and included patient representatives, approved 137 consensus statements that cover several relevant areas in the field of larynx-preserving treatments. Statements are grouped in the following topics: granular indications for T2–T3 cancer, indications for T4a cancer, indications for salvage organ-preservation surgery after chemoradiation failure, laryngeal function at baseline, which comorbidities are contraindications and to what extent, organ preservation in older patients: selection criteria, post-treatment surveillance, prognostic and predictive factors, listening to the patient's preferences: tools and implementation, prehabilitation and rehabilitation protocols, and cost-effectiveness of different laryngeal preservation approaches. We present a high-level summary of the results of the consensus process, with detailed reference to the full list of statements and supporting literature.",

author = "Marco Ferrari and Francesca Mularoni and Davide Smussi and Piergiorgio Gaudioso and Pierluigi Bonomo and Jeppe Friborg and Ghi, \{Maria Grazia\} and Vincent Gregoire and Kevin Harrington and Keith Hunter and Roberto Maroldi and Rosemary Martino and Ricard Mesia and Giorgio Peretti and Amanda Psyrri and Antonio Schindler and Giovanni Succo and Petr Szturz and Isabel Vilaseca and Piero Nicolai and Paolo Bossi and Agarwal, \{Jai Prakash\} and Mohssen Ansarin and Athanassios Argiris and Panagiotis Balermpas and Battisti, \{Nicol{\`o} Matteo Luca\} and Elisa Bellini and Andy Bertolin and Carobbio, \{Andrea Luigi Camillo\} and Chiesa-Estomba, \{Carlos Miguel\} and Beatriz Cirauqui and Erika Crosetti and \{De Oliveira\}, \{Thiago Bueno\} and Alberto Deganello and Andreas Dietz and Eriksen, \{Jesper Grau\} and Antoine Eskander and Nicolas Fakhry and Agustin Falco and Davide Farina and Renata Ferrarotto and Ciro Franzese and \{Ghosh Laskar\}, Sarbani and Wojciech Golusi{\'n}ski and Hanna, \{Ehab Yn\} and Irish, \{Jonathan Crawford\} and Naomi Kiyota and Kowalski, \{Luiz Paulo\} and Suren Krishnan and Nancy Lee and Leemans, \{C. Ren{\'e}\} and Lisa Licitra and Locati, \{Laura Deborah\} and Machiels, \{Jean Pascal\} and Filippo Marchi and Davide Mattavelli and Hisham Mehanna and Giuseppe Mercante and Nausica Montalto and Patrizia Morbini and Brian O'Sullivan and Marc Oliva and Ester Orlandi and Alberto Paderno and Vinidh Paleri and Frank Pameijer and Francesco Perri and Roberto Persio and Cesare Piazza and Yoann Pointreau and Livio Presutti and Marco Ravanelli and Danny Rischin and Rodrigo, \{Juan Pablo\} and Alessandra Ruaro and Giuseppe Sanguineti and Christian Simon and Lillian Siu and Anna Spreafico and Giuseppe Spriano and Stefano Taboni and Umberto Tassini and Silke Tribius and \{Van den Brekel\}, Michiel and \{Vander Poorten\}, Vincent and \{Viros Porcuna\}, David",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd",

year = "2025",

month = may,

doi = "10.1016/S1470-2045(25)00020-8",

language = "English",

volume = "26",

pages = "e264--e281",

journal = "The Lancet Oncology",

issn = "1470-2045",

publisher = "Elsevier Limited",

number = "5",

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Ferrari, M, Mularoni, F, Smussi, D, Gaudioso, P, Bonomo, P, Friborg, J, Ghi, MG, Gregoire, V, Harrington, K, Hunter, K, Maroldi, R, Martino, R, Mesia, R, Peretti, G, Psyrri, A, Schindler, A, Succo, G, Szturz, P, Vilaseca, I, Nicolai, P, Bossi, P, Agarwal, JP, Ansarin, M, Argiris, A, Balermpas, P, Battisti, NML, Bellini, E, Bertolin, A, Carobbio, ALC, Chiesa-Estomba, CM, Cirauqui, B, Crosetti, E, De Oliveira, TB, Deganello, A, Dietz, A, Eriksen, JG, Eskander, A, Fakhry, N, Falco, A, Farina, D, Ferrarotto, R, Franzese, C, Ghosh Laskar, S, Golusiński, W, Hanna, EY, Irish, JC, Kiyota, N, Kowalski, LP, Krishnan, S, Lee, N, Leemans, CR, Licitra, L, Locati, LD, Machiels, JP, Marchi, F, Mattavelli, D, Mehanna, H, Mercante, G, Montalto, N, Morbini, P, O'Sullivan, B, Oliva, M, Orlandi, E, Paderno, A, Paleri, V, Pameijer, F, Perri, F, Persio, R, Piazza, C, Pointreau, Y, Presutti, L, Ravanelli, M, Rischin, D, Rodrigo, JP, Ruaro, A, Sanguineti, G, Simon, C, Siu, L, Spreafico, A, Spriano, G, Taboni, S, Tassini, U, Tribius, S, Van den Brekel, M, Vander Poorten, V & Viros Porcuna, D 2025, 'International consensus on laryngeal preservation strategies in laryngeal and hypopharyngeal cancer', The Lancet Oncology, vol. 26, no. 5, pp. e264-e281. https://doi.org/10.1016/S1470-2045(25)00020-8

TY - JOUR

T1 - International consensus on laryngeal preservation strategies in laryngeal and hypopharyngeal cancer

AU - Ferrari, Marco

AU - Mularoni, Francesca

AU - Smussi, Davide

AU - Gaudioso, Piergiorgio

AU - Bonomo, Pierluigi

AU - Friborg, Jeppe

AU - Ghi, Maria Grazia

AU - Gregoire, Vincent

AU - Harrington, Kevin

AU - Hunter, Keith

AU - Maroldi, Roberto

AU - Martino, Rosemary

AU - Mesia, Ricard

AU - Peretti, Giorgio

AU - Psyrri, Amanda

AU - Schindler, Antonio

AU - Succo, Giovanni

AU - Szturz, Petr

AU - Vilaseca, Isabel

AU - Nicolai, Piero

AU - Bossi, Paolo

AU - Agarwal, Jai Prakash

AU - Ansarin, Mohssen

AU - Argiris, Athanassios

AU - Balermpas, Panagiotis

AU - Battisti, Nicolò Matteo Luca

AU - Bellini, Elisa

AU - Bertolin, Andy

AU - Carobbio, Andrea Luigi Camillo

AU - Chiesa-Estomba, Carlos Miguel

AU - Cirauqui, Beatriz

AU - Crosetti, Erika

AU - De Oliveira, Thiago Bueno

AU - Deganello, Alberto

AU - Dietz, Andreas

AU - Eriksen, Jesper Grau

AU - Eskander, Antoine

AU - Fakhry, Nicolas

AU - Falco, Agustin

AU - Farina, Davide

AU - Ferrarotto, Renata

AU - Franzese, Ciro

AU - Ghosh Laskar, Sarbani

AU - Golusiński, Wojciech

AU - Hanna, Ehab Yn

AU - Irish, Jonathan Crawford

AU - Kiyota, Naomi

AU - Kowalski, Luiz Paulo

AU - Krishnan, Suren

AU - Lee, Nancy

AU - Leemans, C. René

AU - Licitra, Lisa

AU - Locati, Laura Deborah

AU - Machiels, Jean Pascal

AU - Marchi, Filippo

AU - Mattavelli, Davide

AU - Mehanna, Hisham

AU - Mercante, Giuseppe

AU - Montalto, Nausica

AU - Morbini, Patrizia

AU - O'Sullivan, Brian

AU - Oliva, Marc

AU - Orlandi, Ester

AU - Paderno, Alberto

AU - Paleri, Vinidh

AU - Pameijer, Frank

AU - Perri, Francesco

AU - Persio, Roberto

AU - Piazza, Cesare

AU - Pointreau, Yoann

AU - Presutti, Livio

AU - Ravanelli, Marco

AU - Rischin, Danny

AU - Rodrigo, Juan Pablo

AU - Ruaro, Alessandra

AU - Sanguineti, Giuseppe

AU - Simon, Christian

AU - Siu, Lillian

AU - Spreafico, Anna

AU - Spriano, Giuseppe

AU - Taboni, Stefano

AU - Tassini, Umberto

AU - Tribius, Silke

AU - Van den Brekel, Michiel

AU - Vander Poorten, Vincent

AU - Viros Porcuna, David

PY - 2025/5

Y1 - 2025/5

N2 - This Policy Review summarises an expert Delphi consensus process on larynx-preservation treatments in patients affected by intermediate-to-advanced laryngeal or hypopharyngeal squamous cell carcinoma. The experts, who represented all perspectives involved in multidisciplinary management of these patients and included patient representatives, approved 137 consensus statements that cover several relevant areas in the field of larynx-preserving treatments. Statements are grouped in the following topics: granular indications for T2–T3 cancer, indications for T4a cancer, indications for salvage organ-preservation surgery after chemoradiation failure, laryngeal function at baseline, which comorbidities are contraindications and to what extent, organ preservation in older patients: selection criteria, post-treatment surveillance, prognostic and predictive factors, listening to the patient's preferences: tools and implementation, prehabilitation and rehabilitation protocols, and cost-effectiveness of different laryngeal preservation approaches. We present a high-level summary of the results of the consensus process, with detailed reference to the full list of statements and supporting literature.

AB - This Policy Review summarises an expert Delphi consensus process on larynx-preservation treatments in patients affected by intermediate-to-advanced laryngeal or hypopharyngeal squamous cell carcinoma. The experts, who represented all perspectives involved in multidisciplinary management of these patients and included patient representatives, approved 137 consensus statements that cover several relevant areas in the field of larynx-preserving treatments. Statements are grouped in the following topics: granular indications for T2–T3 cancer, indications for T4a cancer, indications for salvage organ-preservation surgery after chemoradiation failure, laryngeal function at baseline, which comorbidities are contraindications and to what extent, organ preservation in older patients: selection criteria, post-treatment surveillance, prognostic and predictive factors, listening to the patient's preferences: tools and implementation, prehabilitation and rehabilitation protocols, and cost-effectiveness of different laryngeal preservation approaches. We present a high-level summary of the results of the consensus process, with detailed reference to the full list of statements and supporting literature.

UR - https://www.scopus.com/pages/publications/105004603591

U2 - 10.1016/S1470-2045(25)00020-8

DO - 10.1016/S1470-2045(25)00020-8

M3 - Review article

C2 - 40318658

AN - SCOPUS:105004603591

SN - 1470-2045

VL - 26

SP - e264-e281

JO - The Lancet Oncology

JF - The Lancet Oncology

IS - 5

ER -

International consensus on laryngeal preservation strategies in laryngeal and hypopharyngeal cancer

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